Cryoablation Combined With Cardonilizumab and Bevacizumab in Hepatocellular Carcinoma With Pulmonary Metastases

NCT ID: NCT06265350

Last Updated: 2024-02-20

Basic Information

• Recruitment Status: RECRUITING
• Clinical Phase: NA
• Total Enrollment: 80 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2024-02-02
• Study Completion Date: 2027-01-30

Brief Summary

This study intends to evaluate the efficacy and safety of cryoablation combined with Cardonilizumab and Bevacizumab in hepatocellular carcinoma with pulmonary metastases.

Detailed Description

For advanced hepatocellular carcinoma (HCC), the lung is the most common metastatic organ, accounting for 30-50% of extrahepatic diseases. The standard therapy for advanced HCC with lung metastases according to the Barcelona Clinic Liver Cancer (BCLC) criteria is system therapy.

However, studies have proven that palliative ablation could improve the tumor controlling effect and the outcomes.

Cryoablation is a treatment method that involves freezing tumors at extremely low temperatures to destroy and eliminate them. This therapeutic approach can result in the death of tumor cells through necrosis and also stimulate immune targeting of tumor cells. These immune responses occur as a result of tumor cell death caused by the ablation procedure. In comparison to conventional cancer therapies, cryoablation has minimal adverse reactions and has the potential to promote a more extensive and effective release of self-generated antigens into the bloodstream.

Targeting vascular endothelial growth factor (VEGF) could reduce VEGF-mediated immunosuppression within the tumor. The IMbrave150 study of atezolizumab and bevacizumab versus sorafenib demonstrated response rates of 29.8% vs 12%, respectively, and median overall survival of 19.8 months in the combination arm versus 13.4 months in the sorafenib (P <0.001). Bevacizumab could enhance anti-PD-1 and anti-programmed death ligand 1 (PD-L1) efficacy by reversing VEGF-mediated immunosuppression and promoting T-cell infiltration in tumors (2).

Cadonilimab is a first-in-class bispecific, humanized IgG1 antibody targeting PD-1 and CTLA-4, which has the potential to boost immune surveillance in tumors. Preclinical studies have shown that its tetravalent design enhances its high binding activity in the tumor microenvironment. With no Fc binding, Cadonilimab could eliminate a series of functions mediated by the Fc receptor, which contribute to a poor safety profile in clinical settings.

Conditions

Hepatocellular Carcinoma; Liver Cancer Stage IV; Pulmonary Metastases; Cadonilimab; Bevacizumab; Cryoablation

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Bevacizumab+Cadonilimab group

Patients accepted Bevacizumab (7.5mg/kg，Q3W， IV) plus Cadonilimab (375mg，Q3W， IV)

Group Type: ACTIVE_COMPARATOR

Cadonilimab

Intervention Type: DRUG

Cadonilimab, 375mg，Q3W， IV

Bevacizumab

Intervention Type: DRUG

Bevacizumab, 7.5mg/kg，Q3W， IV

Cryoablation+Bevacizumab+Cadonilimab

Patients accepted Cryoablation of pulmanary metastases combined with Bevacizumab (7.5mg/kg，Q3W， IV) and Cadonilimab (375mg，Q3W， IV)

Group Type: EXPERIMENTAL

Cadonilimab

Intervention Type: DRUG

Cadonilimab, 375mg，Q3W， IV

Bevacizumab

Intervention Type: DRUG

Bevacizumab, 7.5mg/kg，Q3W， IV

Cryoablation

Intervention Type: PROCEDURE

Patients accepted Cryoablation of pulmanary metastases

Interventions

Cadonilimab

Cadonilimab, 375mg，Q3W， IV

Intervention Type: DRUG

Bevacizumab

Bevacizumab, 7.5mg/kg，Q3W， IV

Intervention Type: DRUG

Cryoablation

Patients accepted Cryoablation of pulmanary metastases

Intervention Type: PROCEDURE

Eligibility Criteria

Inclusion Criteria

1. primary or recurrent HCC;

2. synchronous metastases (within one month after diagnosing of HCC) or asynchronous metastases (more than one month after diagnosis of HCC);

3. pulmonary-only metastases >5 and ≤10;

4. metastases diameter ≤ 5 cm;

5. intrahepatic tumors ≤5, and tumor burden ≤1/2 liver volume;

6. PVTT type Vp≤3;

7. patients underwent first-line system therapy failure, the first-line system included tyrosine kinase inhibitor (TKI), such as Sorafenib or Lenvatinib, with or without PD-1 or PDL1 inhibitor;

8. the intrahepatic tumors were effectively controlled and pulmonary metastases were no progression, and the controlled intrahepatic tumors were defined as partial or stable response according to modified Response Evaluation Criteria in Solid Tumors (mRECIST);

9. locoregional therapy (including TACE or HAIC) were also included;

10. Child-Pugh class A or B;

11. PS 0 or 1;

12. no history of other malignancies.

Exclusion Criteria

1. under 18 years or over 75 years;

2. metastases >10

3. non-lung metastases;

4. incomplete clinical data;

5. metastases diameter > 5 cm;

6. intrahepatic tumors > 5, and tumor burden > 1/2 liver volume;

7. PVTT type Vp 4;

8. lost to follow-up within 3 months.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 75 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Sun Yat-sen University

OTHER

Sponsor Role: lead

Responsible Party

Zhou Qunfang

Clinical Professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Zhimei Hunag, MD

Role: STUDY_DIRECTOR

Sun Yat-sen University

Jinhua Huang, MD

Role: STUDY_DIRECTOR

Sun Yat-sen University

Locations

Sun Yat-sen University Cancer Center

Guanzhou, Guangdong, China

Site Status: RECRUITING

Sun Yat-sen University Cancer Center

Guanzhou, Guangdong, China

Site Status: RECRUITING

Countries

China

Central Contacts

Qunfang Zhou, MD

Role: CONTACT

zhouqun988509@163.com

86 19868000115

Facility Contacts

Qunfang Zhou, MD

Role: primary

zhouqun988509@163.com

86 19868000115

Qunfang Zhou, MD

Role: primary

zhouqun988509@163.com

8619868000115

Other Identifiers

Liver Project 5

Identifier Type: -

Identifier Source: org_study_id