Prospective Registry to Evaluate Outcomes of NanoBone® Bone Graft in Acute Trauma

NCT ID: NCT06256458

Last Updated: 2025-02-12

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

200 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-12-01

Study Completion Date

2026-12-01

Brief Summary

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This multicenter prospective patient registry was developed with the aim of documenting how orthopedic surgeons are utilizing the NanoBone products in acute trauma cases along with relevant patient outcomes. These outcomes include radiographic measures such as fracture healing, instrumentation integrity, and clinical outcomes (symptom and function improvement) based on investigator and patient-based outcome assessments.

Detailed Description

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This multicenter prospective patient registry was developed with the aim of documenting how orthopedic surgeons are utilizing the NanoBone products in acute trauma cases along with relevant patient outcomes. These outcomes include radiographic measures such as fracture healing, instrumentation integrity, and clinical outcomes (symptom and function improvement) based on investigator and patient-based outcome assessments.

The primary objective of this study is to document and analyze the use of NanoBone products in acute trauma cases (as a stand-alone bone graft, or in combination with local bone only, no other bone graft substitute or biologic product used) and determine both radiographic success and clinical outcomes. All product related adverse events will be documented, tabulated, and summarized.

Conditions

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Fractures, Bone

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Interventions

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NanoBone® Bone Graft

The surgical technique used by the surgeon and the choice of the specific NanoBone product is or was determined solely by the surgeon and is independent of this observational study.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

1. Subjects at least 18 years old at the time of injury
2. Acute fractures, resulting from blunt or penetrating trauma

* In the extremities or pelvis
* Requiring surgery
* Treated emergently, delayed or staged up to 4 weeks from the date of injury
* Where bone grafting is clinically indicated

Exclusion Criteria

1. Certain fracture locations (these apply to non-unions as well)

* Hand - metacarpals, phalanges
* Forefoot - metatarsals, phalanges
* Skull
* Spine
2. Fractures requiring definitive fracture stabilization beyond the initial 4 weeks from the date of injury
3. Pathologic fractures secondary to malignancy
4. Subjects unable to follow recommended post-operative plan and complete follow ups
5. Subjects unable to complete patient reported outcome measures
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Artoss Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Mitchell D Kuhl, DO

Role: PRINCIPAL_INVESTIGATOR

SSM Health

Locations

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SSM Health St. Mary's Hospital

Madison, Wisconsin, United States

Site Status RECRUITING

Countries

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United States

Central Contacts

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James J Cassidy, Ph.D.

Role: CONTACT

320-259-4321

Facility Contacts

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Mitchell D Kuhl, DO

Role: primary

608-294-6464

Other Identifiers

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ART001

Identifier Type: -

Identifier Source: org_study_id

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