Tranexamic Acid After Pathological Fracture Treated With Modular Arthroplasty

NCT ID: NCT06244498

Last Updated: 2024-02-06

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

110 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-01-01

Study Completion Date

2022-12-31

Brief Summary

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This study assesses the safety and efficacy of TXA for patients treated for pathological femur fractures using modular prosthetics.

Detailed Description

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Tranexamic acid is an efficacious medication for curtailing blood loss, haemoglobin drop, and the requirement for transfusions. Additionally, it is a secure medication, even when administered to oncology patients receiving reduction haemarthroplasty for pathological femoral fractures.

Conditions

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Metastases to Bone

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

RETROSPECTIVE

Study Groups

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TXA

Tranexamic acid was administered to the participants at a dose of 1.0 g during the induction of anaesthesia and immediately after the operation.

Tranexamic acid injection

Intervention Type DRUG

Tranexamic acid were administered at a dose of 1.0 g during the induction of anaesthesia and immediately after surgery.

Non-TXA

Tranexamic acid were not administred to the participants .

No interventions assigned to this group

Interventions

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Tranexamic acid injection

Tranexamic acid were administered at a dose of 1.0 g during the induction of anaesthesia and immediately after surgery.

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Patological fracture
* Arthroplasty using a modular prosthesis.

Exclusion Criteria

* threatened fracture
* intraoperative blood transfusion
* fracture fixation
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Piotr Biega

OTHER

Sponsor Role lead

Responsible Party

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Piotr Biega

Principal Investigator, Rzeszow University of Technology - Assistant Professor

Responsibility Role SPONSOR_INVESTIGATOR

Locations

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SzSPOO Brzozów

Brzozów, Podkarpackie Voivodeship, Poland

Site Status

Countries

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Poland

References

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CRASH-2 collaborators; Roberts I, Shakur H, Afolabi A, Brohi K, Coats T, Dewan Y, Gando S, Guyatt G, Hunt BJ, Morales C, Perel P, Prieto-Merino D, Woolley T. The importance of early treatment with tranexamic acid in bleeding trauma patients: an exploratory analysis of the CRASH-2 randomised controlled trial. Lancet. 2011 Mar 26;377(9771):1096-101, 1101.e1-2. doi: 10.1016/S0140-6736(11)60278-X.

Reference Type RESULT
PMID: 21439633 (View on PubMed)

Other Identifiers

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01

Identifier Type: -

Identifier Source: org_study_id

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