The Effect of Semaglutide on Disordered Eating Behaviour in Type 2 Diabetic Patients
NCT ID: NCT06243536
Last Updated: 2024-02-06
Study Results
Results pending
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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Recruitment Status
NOT_YET_RECRUITING
Clinical Phase
PHASE4
Total Enrollment
60 participants
Study Classification
INTERVENTIONAL
Study Start Date
2024-02-01
Study Completion Date
2024-12-31
Brief Summary
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The aim of this study is to evaluate the effect of glucagon-like peptide-1 (GLP-1) receptor agonist semaglutide on disordered eating behaviour in patients with overweight and type 2 diabetes. The investigators will also evaluate serum concentrations of incretin hormones GLP-1 and glucose-dependent insulinotropic polypeptide (GIP), as well as glucose variability using continuous glucose monitoring (CGM) devices before and after semaglutide, and determine his influence on eating disorders.
In this prospective study the investigators aim to recruit 60 patients with type 2 diabetes and randomize them based on the presence of a disordered eating behaviour diagnosed by a validated questionnaire (1:1). Patients with a disordered eating behaviour will further be randomized (1:1) to receive semaglutide. At baseline and after 12 weeks of semaglutide therapy, the investigators will reevaluate glucose variability over 14 days using a continuous glucose monitoring device (CGM).
With this study the investigators will determine the impact of GLP-1 receptor agonist semaglutide on disordered eating behaviour in patients with overweight and type 2 diabetes. This study will contribute to the knowledge about the role of incretin hormones and glucose variability in eating disorders in this population of patients.
In this prospective study the investigators aim to recruit 60 patients with type 2 diabetes and randomize them based on the presence of a disordered eating behaviour diagnosed by a validated questionnaire (1:1). Patients with a disordered eating behaviour will further be randomized (1:1) to receive semaglutide. At baseline and after 12 weeks of semaglutide therapy, the investigators will reevaluate glucose variability over 14 days using a continuous glucose monitoring device (CGM).
With this study the investigators will determine the impact of GLP-1 receptor agonist semaglutide on disordered eating behaviour in patients with overweight and type 2 diabetes. This study will contribute to the knowledge about the role of incretin hormones and glucose variability in eating disorders in this population of patients.
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Detailed Description
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This randomized controlled trial will be conducted in Clinical Hospital Center Sestre milosrdnice and University of Zagreb School of medicine. Patients will be randomized after completing the EAT-26 questionnaire (1:1), in group with disordered eating behaviour (n=30) if participants scored \>20 points, and group without disordered eating behaviour (n=30) if participants scored ≤20 points. Group of patients with disordered eating behaviour will be further randomized whether participants will receive semaglutide (n=15) with standard care or if participants will be treated with standard care (n=15). The investigators will evaluate baseline EAT-26 score, GLP-1 and GIP blood levels in a mixed meal test, anthropometric measurements (weight, BMI, waist circumference), biochemical parameters (complete blood count, glucose, insulin, c-peptide, HbA1c, urea, creatinine, uric acid, aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyltransferase (GGT), international normalized ratio (INR), albumin, serum lipid levels (cholesterol. HDL, LDL, triglyceride), C reactive protein (CRP), urine sediment and their changes at the end of the trial (except mixed meal test). Also, through 14 days at the beginning and 14 days before the end of the trial, patients will keep a food diary and have intermittently scanned continuous glucose monitor (FreeStyle Libre Pro CGM device, Abbott).
A factor analysis of EAT-26 scores will be conducted to form 3 (expected) latent variables (components). To assess the effect on dietary habits, the difference in EAT-26 total score and latent variables between subjects randomized to semaglutide and control subjects (randomized to standard care) will be assessed after 3 months of treatment. The data will be analysed in a general linear model, with basal covariates: age, sex, BMI and score at the beginning of treatment. In the same way, the effect of semaglutide on GLP1 concentrations (basal covariate: basal concentration next to the location of the EAT-26 score) will be evaluated, separately for the condition before and after the mixed meal test. GLP-1 and GIP concentrations will be compared between subjects with ("exposed") and without (control) eating disorders, in a generalized linear model for repeated measurements (GLP-1 concentration before and after mixed meal test) with fixed covariates: age, sex, BMI, time ( before or after mixed meal test) and exposure\*time interactions. Type I (α) error=0.05.
A factor analysis of EAT-26 scores will be conducted to form 3 (expected) latent variables (components). To assess the effect on dietary habits, the difference in EAT-26 total score and latent variables between subjects randomized to semaglutide and control subjects (randomized to standard care) will be assessed after 3 months of treatment. The data will be analysed in a general linear model, with basal covariates: age, sex, BMI and score at the beginning of treatment. In the same way, the effect of semaglutide on GLP1 concentrations (basal covariate: basal concentration next to the location of the EAT-26 score) will be evaluated, separately for the condition before and after the mixed meal test. GLP-1 and GIP concentrations will be compared between subjects with ("exposed") and without (control) eating disorders, in a generalized linear model for repeated measurements (GLP-1 concentration before and after mixed meal test) with fixed covariates: age, sex, BMI, time ( before or after mixed meal test) and exposure\*time interactions. Type I (α) error=0.05.
Conditions
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Type 2 Diabetes
Overweight
Disordered Eating Behaviors
Study Design
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Allocation Method
RANDOMIZED
Intervention Model
PARALLEL
Primary Study Purpose
TREATMENT
Blinding Strategy
SINGLE
Outcome Assessors
Study Groups
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Type 2 diabetic patients without disordered eating behaviour
Treated with standard of care.
Group Type
PLACEBO_COMPARATOR
standard of care
Intervention Type
DRUG
Patients not assigned to receive semaglutide will receive standard of care.
Type 2 diabetic patients with disordered eating behaviour A
Treated with standard of care.
Group Type
PLACEBO_COMPARATOR
standard of care
Intervention Type
DRUG
Patients not assigned to receive semaglutide will receive standard of care.
Type 2 diabetic patients with disordered eating behaviour B
Receiving semaglutide for 12 weeks
Group Type
EXPERIMENTAL
Semaglutide
Intervention Type
DRUG
Semaglutide will be administered through 12 weeks.
Interventions
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Semaglutide
Semaglutide will be administered through 12 weeks.
Intervention Type
DRUG
standard of care
Patients not assigned to receive semaglutide will receive standard of care.
Intervention Type
DRUG
Other Intervention Names
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Metformin, Sulfonylureas, Sodium-glucose cotransporter-2 inhibitors, pioglitazone
Eligibility Criteria
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Inclusion Criteria
* type 2 diabetes, age 18-65, BMI ≥28 kg/m2, HbA1c\>7%, glp-1 receptor agonist naïve
Exclusion Criteria
* hepatic impairment (Child Pugh score C), renal impairment (eGFR\<30 ml/min), use of medication that affect eating (GLP-1 receptor agonists, antidepressants, antiobesity medications, glucocorticoids, insulin, oral contraceptives, hormonal therapy), conditions that can affect eating (hypothyroidism, hyperthyroidism, Cushing syndrome, acromegaly, adrenal insufficiency, pregnancy, breastfeeding), contraindications for semaglutide
Minimum Eligible Age
18 Years
Maximum Eligible Age
65 Years
Eligible Sex
ALL
Accepts Healthy Volunteers
No
Sponsors
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University of Zagreb School of Medicine
UNKNOWN
Sponsor Role
collaborator
University Hospital Sestre Milosrdnice
OTHER
Sponsor Role
lead
Responsible Party
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Jelena Marinkovic Radosevic
Principal Ivenstigator
Responsibility Role
PRINCIPAL_INVESTIGATOR
Principal Investigators
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Jelena Osmanović Barilar, Professor
Role: STUDY_CHAIR
University of Zagreb School of Medicine
Locations
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UH Sestre milosrdnice
Zagreb, , Croatia
Site Status
Countries
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Croatia
Central Contacts
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Facility Contacts
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References
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Related Links
Access external resources that provide additional context or updates about the study.
http://diabetesatlas.org
Magliano DJ, Boyko EJ; IDF Diabetes Atlas 10th edition scientific committee. IDF diabetes atlas 10th ed. \[Internet\]. Brussels: International Diabetes Federation; 2021
https://www.hzjz.hr/wp-content/uploads/2023/03/Izvjesce_za_2022_godinu.pdf
Buble T, Čavlina M. Nacionalni registar osoba sa šećernom bolešću CroDiab. Izvješće za 2022. \[Internet\]. Zagreb: Hrvatski zavod za javno zdravstvo; 2022
http://www.ars.usda.gov/nutrientdata
U. S. Department of Agriculture, Agricultural Research Service. USDA National Nutrient Database for Standard Reference, Legacy Release. \[Internet\]. 2018
Other Identifiers
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251-29-1 1/3-23-06
Identifier Type: -
Identifier Source: org_study_id
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