Doxycycline PEP and 4CMenB as a Comprehensive Prevention Strategy in MSM and TGW at High Risk for Bacterial STIs Within the Swiss HIV Cohort Study

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

400 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-11-01

Study Completion Date

2025-10-31

Brief Summary

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The study aims at assessing effectiveness of offering event-driven Doxy PEP and 4CMenB immunization in MSM/TGW at high STI risk. It plans to offer this STI prevention package to all MSM/TGW in the SHCS who are at risk of STI and then comparing 12-months STI incidence between those accepting and those not accepting the prevention package. The proposal further hosts two interesting sub-studies: One assessing potential effect of Doxy PEP on the microbiome and the other one assessing potential impact of Doxy PEP on TP, MG and CT resistance.

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Detailed Description

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Conditions

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Doxycycline STI PEP

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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People living with HIV participating in the Swiss HIV Cohort Study on doxycycline STI PEP

The target population for this study are MSM or TGW at high risk for a bacterial STI (≥1 occasional partners within the preceding 6 months) taking teh doxycycline STI PEP

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

≥ 18 years of age

* Participant in the SHCS
* On antiretroviral therapy with suppressed viral load for ≥ 3 months
* MSM or TGW
* ≥ 1 bacterial STI (syphilis, CT, MG, or NG) within the past 3 years and/or reporting condomless sex with ≥ 1 occasional partner within the last 6 months
* Consenting for off-label use of doxycycline as PEP and/or 4CMenB for the prevention of bacterial STIs
* No allergy or intolerance to doxycycline or 4CMenB
* No other contraindication for doxycycline (e. g. co-medication)