Impact of GLP-1 RAs Compared to Basal Insulin Start in Patients Living With Type 2 Diabetes and Chronic Kidney Disease

NCT ID: NCT06236672

Last Updated: 2024-02-01

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 348 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2023-02-15
• Study Completion Date: 2023-11-29

Brief Summary

The overall objective of this study is to compare the effectiveness of adding a glucagon-like peptide-1 receptor agonist compared with adding basal insulin for patients with type 2 diabetes and chronic kidney disease, already treated with an sodium-glucose cotransporter-2 inhibitor and not currently reaching target glycemic control. All sociodemographic information and clinical variables will be retrieved from the LMC Diabetes Registry.

Detailed Description

This study is a retrospective, non-inferiority cohort study using demographic and clinical data from the LMC Diabetes Registry. The study population will be adult patients with type 2 diabetes (T2D) and chronic kidney disease (CKD) with a background antihyperglycemic treatment (AHA) of a sodium-glucose cotransporter-2 inhibitor (SGLT2i) at LMC Diabetes & Endocrinology. Two cohorts will be assessed for eligibility: patients who initiated a glucagon-like peptide-1 receptor agonist (GLP-1 RA), and patients who initiated a basal insulin, between January 2019 and December 2022. Only patients who have given consent for their medical records to be used for research purposes will be included. The date that the GLP-1 RA or the basal insulin was initiated will be considered the index date as well as the baseline date.

The LMC Diabetes Registry will be queried to retrieve information for the sociodemographic information and clinical outcomes. Baseline characteristics such as HbA1c, blood pressure, eGFR, uACR, ALT, low-density lipoprotein (LDL), high-density lipoprotein (HDL), cholesterol, triglycerides, body weight, and BMI at the time of GLP-1 RA or basal insulin initiation will be recorded. Subsequent changes in these variables, self-reported hypoglycemic events, proportion of patients with HbA1c ≤ 6.5% and ≤ 7.0%, proportion of patients who discontinued GLP-1 RA or basal insulin will be recorded at the last available follow-up visit at 26-52 weeks following the index date.

Patients initiating a GLP-1 RA will be matched 1:1 to patients initiating a basal insulin by means of propensity score matching. The propensity score (odds of participants' treatment being GLP- 1 RA) will be estimated with a logistic regression model, with GLP-1 RA use as the outcome variable and the following variables to be potentially used as covariates: age, gender, ethnicity, education, duration of T2D (years), BMI, systolic blood pressure, HbA1c at baseline, fasting plasma lipids (LDL, HDL), AHA (dual, triple, quadruple, add on to insulin), comorbidities (macrovascular complications, microvascular complications, hypertension, dyslipidemia, smoking status,), anti-hypertensive therapy, and lipid lowering therapy.

The primary objective of the study is to compare the change in HbA1c from baseline to follow-up (26-to-52 weeks) between the GLP-1 RA initiation group and the basal insulin initiation group in patients diagnosed T2D and CKD, treated with an SGLT2i. Only patients who provide a primary endpoint value at 26-52 weeks on-treatment will be included in the primary endpoint evaluation.

Conditions

Type 2 Diabetes; Chronic Kidney Diseases

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: RETROSPECTIVE

Study Groups

GLP-1 RA group

adult patients with T2D and CKD who initiated GLP-1 RA therapy

GLP-1 receptor agonist

Intervention Type: DRUG

GLP-1 RA initiated between January 2019 and December 2022

basal insulin group

adult patients with T2D and CKD who initiated basal insulin therapy

basal insulin

Intervention Type: DRUG

basal insulin initiated between January 2019 and December 2022

Interventions

GLP-1 receptor agonist

GLP-1 RA initiated between January 2019 and December 2022

Intervention Type: DRUG

basal insulin

basal insulin initiated between January 2019 and December 2022

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

• 18 years or older as of the index date
• Clinical diagnosis of T2D ≥ one year
• Diagnosis of CKD (defined by Diabetes Canada guideline) with eGFR 15-59 ml/min/1.73m2, or eGFR ≥ 60 ml/min/1.73m2 with the uACR ≥ 2mmol/L
• Use of any SGLT2i for more than 6 months
• Baseline HbA1c ≥7.5%

Exclusion Criteria

• Clinical diagnosis of type 1 diabetes (T1D)
• Most recent eGFR ≤ 15 ml/min/1.73 m2
• Documented history or family history of Medullary Thyroid Carcinoma or Multiple Endocrine Neoplasia type 2
• Hypersensitivity to GLP-1 RA or any product component
• Initiation of a second AHA therapy on the index date together with GLP-1RA
• Previous use of any GLP-1 RA therapy
• Previous use of basal and bolus insulin therapy
• Participation in a research study with an Investigational Product

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Novo Nordisk Canada Inc.

UNKNOWN

Sponsor Role: collaborator

LMC Diabetes & Endocrinology Ltd.

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Alexander Abitbol, MD

Role: PRINCIPAL_INVESTIGATOR

LMC Diabetes & Endocrinology Ltd.

Locations

LMC Diabetes & Endocrinology Ltd.

Toronto, Ontario, Canada

Countries

Canada

Other Identifiers

Impact GLP-1 CKD

Identifier Type: -

Identifier Source: org_study_id