A Study of LY3841136 Compared With Placebo in Adult Participants With Obesity or Overweight
NCT ID: NCT06230523
Last Updated: 2025-08-28
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
PHASE2
263 participants
INTERVENTIONAL
2024-02-05
2025-08-14
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
DOUBLE
Study Groups
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LY3841136 Dose 1
Participants will receive LY3841136 subcutaneously (SC)
LY3841136
Administered SC.
LY3841136 Dose 2
Participants will receive LY3841136 SC
LY3841136
Administered SC.
LY3841136 Dose 3
Participants will receive LY3841136 SC
LY3841136
Administered SC.
LY3841136 Dose 4
Participants will receive LY3841136 SC.
LY3841136
Administered SC.
LY3841136 Dose 5
Participants will receive LY3841136 SC
LY3841136
Administered SC.
LY3841136 Dose 6
Participants will receive LY3841136 SC
LY3841136
Administered SC.
Placebo
Participants will receive LY3841136 matching placebo
Placebo
Administered SC.
Interventions
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LY3841136
Administered SC.
Placebo
Administered SC.
Eligibility Criteria
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Inclusion Criteria
* Are males and females who agree to abide by the reproductive and contraceptive requirements
W8M-MC-CWMM:
* Have a BMI ≥27 kg/m²
* Have had a stable body weight for the 3 months prior to randomization (\<5% body weight gain and/or loss)
Exclusion Criteria
* Have any prior diagnosis of diabetes mellitus except gestational diabetes.
* Have any of the following cardiovascular conditions within 6 months prior to screening:
* acute myocardial infarction
* cerebrovascular accident (stroke)
* unstable angina, or
* hospitalization due to congestive heart failure (CHF).
* Have a history of acute or chronic pancreatitis.
* Have an on-going or history of bradyarrhythmia and/or sinus bradycardia at screening and baseline.
W8M-MC-CWMM
* Have a prior or planned surgical treatment for obesity, except prior liposuction or abdominoplasty, if performed \>1 year prior to screening.
* Have type 1 diabetes mellitus, latent autoimmune diabetes in adults, or history of ketoacidosis or hyperosmolar coma.
* Have poorly controlled hypertension.
* Have a history of symptomatic gallbladder disease within the past 2 years
* Have signs and symptoms of any liver disease other than nonalcoholic fatty liver disease.
* Have a lifetime history of suicide attempts.
18 Years
75 Years
ALL
No
Sponsors
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Eli Lilly and Company
INDUSTRY
Responsible Party
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Principal Investigators
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Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 9 AM - 5 PM Eastern time (UTC/GMT - 5 hours, EST)
Role: STUDY_DIRECTOR
Eli Lilly and Company
Locations
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The Institute for Liver Health II dba Arizona Clinical Trials - Mesa
Chandler, Arizona, United States
Headlands Research - Scottsdale
Scottsdale, Arizona, United States
The Institute for Liver Health II dba Arizona Liver Health-Tucson
Tucson, Arizona, United States
NorCal Medical Research, Inc
Greenbrae, California, United States
Velocity Clinical Research, Huntington Park
Huntington Park, California, United States
Peninsula Research Associates
Rolling Hills Estates, California, United States
Diablo Clinical Research, Inc.
Walnut Creek, California, United States
Northeast Research Institute (NERI)
Fleming Island, Florida, United States
Suncoast Clinical Research, Inc.
New Port Richey, Florida, United States
Charter Research - Winter Park
Orlando, Florida, United States
Charter Research - Lady Lake
The Villages, Florida, United States
Pacific Diabetes & Endocrine Center
Honolulu, Hawaii, United States
Medical Research Partners
Ammon, Idaho, United States
Great Lakes Clinical Trials - Andersonville
Chicago, Illinois, United States
Great Lakes Clinical Trials - Ravenswood
Chicago, Illinois, United States
NorthShore University Health System
Skokie, Illinois, United States
Iowa Diabetes and Endocrinology Research Center
West Des Moines, Iowa, United States
Cotton O'Neil Diabetes & Endocrinology
Topeka, Kansas, United States
L-MARC Research Center
Louisville, Kentucky, United States
Knownwell
Needham, Massachusetts, United States
Lucida Clinical Trials
New Bedford, Massachusetts, United States
Headlands Research - Detroit
Southfield, Michigan, United States
Arcturus Healthcare , PLC, Troy Internal Medicine Research Division
Troy, Michigan, United States
StudyMetrix Research
City of Saint Peters, Missouri, United States
Las Vegas Medical Research
Las Vegas, Nevada, United States
Dent Neurologic Institute
Amherst, New York, United States
Velocity Clinical Research, Syracuse
East Syracuse, New York, United States
North Suffolk Neurology
Port Jefferson Station, New York, United States
Rochester Clinical Research, LLC
Rochester, New York, United States
Medication Management
Greensboro, North Carolina, United States
Monroe Biomedical Research
Monroe, North Carolina, United States
Lucas Research, Inc.
New Bern, North Carolina, United States
CTI Clinical Research Center
Cincinnati, Ohio, United States
Tribe Clinical Research, LLC
Greenville, South Carolina, United States
Quality Medical Research
Nashville, Tennessee, United States
IMA Clinical Research Austin
Austin, Texas, United States
Velocity Clinical Research, Dallas
Dallas, Texas, United States
FutureSearch Trials of Dallas
Dallas, Texas, United States
PlanIt Research, PLLC
Houston, Texas, United States
Tekton Research - Fredericksburg Road
San Antonio, Texas, United States
Endeavor Clinical Trials
San Antonio, Texas, United States
Spectrum Medical, Inc.
Danville, Virginia, United States
Central Washington Health Services Association d/b/a Confluence Health
Wenatchee, Washington, United States
Centro Médico Viamonte
Buenos Aires, Buenos Aires F.D., Argentina
Centro Medico Dra. Laura Maffei- Investigacion Clinica Aplicada
Buenos Aires, Buenos Aires F.D., Argentina
Centro de Investigaciones Metabólicas (CINME)
Buenos Aires, , Argentina
Countries
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Related Links
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A Study of LY3841136 Compared With Placebo in Adult Participants With Obesity or Overweight
Other Identifiers
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W8M-MC-LAA1
Identifier Type: OTHER
Identifier Source: secondary_id
CWMM Master Protocol
Identifier Type: OTHER
Identifier Source: secondary_id
18808
Identifier Type: -
Identifier Source: org_study_id
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