Patient-Reported Outcomes for Lemborexant in Chinese Participants With Insomnia

NCT ID: NCT06225947

Last Updated: 2024-07-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

200 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-02-22

Study Completion Date

2025-06-30

Brief Summary

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This study is a prospective, open-label, single arm, multicenter study lasting 12 weeks to evaluate effectiveness and safety of lemborexant(LEM). Patient self-evaluation reports and safety events will be collected at baseline and 4 visits during treatment.

Detailed Description

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This study is a prospective, open-label, single arm, multicenter study lasting 12 weeks to evaluate effectiveness and safety of lemborexant(LEM). Adult patients diagnosed with insomnia (including chronic and short-term insomnia) in the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) and ISI ≥10, clinically judged to need pharmacological treatment will be enrolled.Patients will be administered with LEM, and patient self-evaluation reports and safety events will be collected at baseline and each visit during treatment.

Conditions

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Insomnia

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Lemborexant(LEM)

Subjects will be administered with Lemborexant(LEM). The dosage of LEM is 5 mg or 10mg taken no more than once per night during the study.

Lemborexant 5 MG

Intervention Type DRUG

The recommended dosage of Lemborexant(LEM) is 5 mg taken no more than once per night, immediately before going to bed, with at least 7 hours remaining before the planned time of awakening. The dose may be increased to the maximum recommended dose of 10 mg based on clinical response and tolerability.

Interventions

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Lemborexant 5 MG

The recommended dosage of Lemborexant(LEM) is 5 mg taken no more than once per night, immediately before going to bed, with at least 7 hours remaining before the planned time of awakening. The dose may be increased to the maximum recommended dose of 10 mg based on clinical response and tolerability.

Intervention Type DRUG

Other Intervention Names

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DAYVIGO

Eligibility Criteria

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Inclusion Criteria

* Adults (≥18 years) and agreed to participate in the study, regardless of gender.
* Diagnosed with insomnia according to DSM-5.
* Insomnia Severity Index (ISI) score \>10.
* Subjects who can guarantee at least 7 hours of bedtime.
* Subjects signed informed consent forms after the prescription.

Exclusion Criteria

* Beings unable to understand the questionnaire.
* PHQ-9 scores ≥ 20.
* GAD-7 scores ≥ 15.
* Suicidal thoughts/behaviors in the past one month or history of suicide, etc.
* Severe psychiatric disorder in the judgment of the investigator prevents completion of the trial.
* History of serious illness, mental illness, medication use, and uncontrolled poor sleep habits that the investigator believes interfere with the study evaluation or the safety of the subject.
* According to the precautions listed in the instructions, there are any contraindications or other conditions for which the use is prohibited (such as narcolepsy, severe liver damage, pregnant, nursing or pregnant women, etc.).
* Other conditions not considered appropriate for participation by clinicians.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Nanfang Hospital, Southern Medical University

OTHER

Sponsor Role collaborator

Guangdong Provincial People's Hospital

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Fujun Jia, MD

Role: PRINCIPAL_INVESTIGATOR

Guangdong Provincial People's Hospital

Bin Zhang, MD

Role: PRINCIPAL_INVESTIGATOR

Nanfang Hospital, Southern Medical University

Locations

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Guangdong Provincial People's Hospital

Guangzhou, Guangdong, China

Site Status RECRUITING

Sun Yat-sen Memorial Hospital

Guangzhou, Guangdong, China

Site Status RECRUITING

Guangzhou United Family Hospital

Guangzhou, Guangdong, China

Site Status RECRUITING

Nanfang Hospital

Guangzhou, Guangdong, China

Site Status RECRUITING

Clifford Hospital

Guangzhou, Guangdong, China

Site Status RECRUITING

Countries

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China

Central Contacts

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Xueli Li, Master

Role: CONTACT

15876549787

Shuqiong Zheng, Master

Role: CONTACT

13192676969

Facility Contacts

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Xueli Li, Master

Role: primary

15876549787

Yin Chen, MD

Role: primary

1357088851

Jin Li, PHD

Role: primary

13824492310

Shuqiong Zheng, Master

Role: primary

13192676969

Qian Wu, Bachelor

Role: primary

13760787879

Other Identifiers

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KY2023-1072-02

Identifier Type: -

Identifier Source: org_study_id

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