Efficacy of Low Dose Propofol Given at the End of Sevoflurane Anesthesia for Prevention of Emergence Agitation in Pediatric Patient Undergoing MRI Scan
NCT ID: NCT06218680
Last Updated: 2024-01-23
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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NOT_YET_RECRUITING
NA
134 participants
INTERVENTIONAL
2024-01-20
2025-04-30
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
PREVENTION
TRIPLE
Study Groups
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group P
Receive 0.5 mg/kg of propofol intravenously at end of sevoflurane anesthesia
Propofol
recieve propofol 0.5 mg/kg intravenously at end of sevoflurane anesthesia
group S
Receive saline intravenously at end of sevoflurane anesthesia
Normal saline
recieve propofol 0.5 mg/kg intravenously at end of sevoflurane anesthesia
Interventions
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Propofol
recieve propofol 0.5 mg/kg intravenously at end of sevoflurane anesthesia
Normal saline
recieve propofol 0.5 mg/kg intravenously at end of sevoflurane anesthesia
Eligibility Criteria
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Inclusion Criteria
* ASA class I or II ,who schedule for MRI scan under sevoflurane anesthesia
Exclusion Criteria
* Psychological and neurological disorders
* Abnormal airway
* Reactive airway disease
* Allergy to propofol, egg product
* Family history of malignant hyperthermia
* Need iv sedative medication before induction
* Obesity
1 Year
8 Years
ALL
No
Sponsors
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Khon Kaen University
OTHER
Responsible Party
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Santhita Pimonbut
Santhita Pimonbut
Principal Investigators
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Santhita Pimonbut, M.D.
Role: PRINCIPAL_INVESTIGATOR
department of anesthesiology, faculty of medicine, Khonkaen University
Locations
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Khon kaen University
Khon Kaen, Muang, Thailand
Countries
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Central Contacts
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Facility Contacts
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References
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Kulka PJ, Bressem M, Tryba M. Clonidine prevents sevoflurane-induced agitation in children. Anesth Analg. 2001 Aug;93(2):335-8, 2nd contents page.
Welborn LG, Hannallah RS, Norden JM, Ruttimann UE, Callan CM. Comparison of emergence and recovery characteristics of sevoflurane, desflurane, and halothane in pediatric ambulatory patients. Anesth Analg. 1996 Nov;83(5):917-20. doi: 10.1097/00000539-199611000-00005.
Aouad MT, Yazbeck-Karam VG, Nasr VG, El-Khatib MF, Kanazi GE, Bleik JH. A single dose of propofol at the end of surgery for the prevention of emergence agitation in children undergoing strabismus surgery during sevoflurane anesthesia. Anesthesiology. 2007 Nov;107(5):733-8. doi: 10.1097/01.anes.0000287009.46896.a7.
Cravero JP, Beach M, Thyr B, Whalen K. The effect of small dose fentanyl on the emergence characteristics of pediatric patients after sevoflurane anesthesia without surgery. Anesth Analg. 2003 Aug;97(2):364-367. doi: 10.1213/01.ANE.0000070227.78670.43.
Costi D, Ellwood J, Wallace A, Ahmed S, Waring L, Cyna A. Transition to propofol after sevoflurane anesthesia to prevent emergence agitation: a randomized controlled trial. Paediatr Anaesth. 2015 May;25(5):517-23. doi: 10.1111/pan.12617. Epub 2015 Jan 13.
Ramlan AAW, Pardede DKB, Marsaban AHMS, Hidayat J, Peddyandhari FS. Efficacy of 0.5 mg/kg of propofol at the end of anesthesia to reduce the incidence of emergence agitation in children undergoing general anesthesia with sevoflurane. J Anaesthesiol Clin Pharmacol. 2020 Apr-Jun;36(2):177-181. doi: 10.4103/joacp.JOACP_257_19. Epub 2020 Jun 15.
Abu-Shahwan I. Effect of propofol on emergence behavior in children after sevoflurane general anesthesia. Paediatr Anaesth. 2008 Jan;18(1):55-9. doi: 10.1111/j.1460-9592.2007.02376.x.
Other Identifiers
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HE661348
Identifier Type: -
Identifier Source: org_study_id
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