The Effect of Renastart Formula Supplementation in Children With Acute Kidney Injury in Maintaining Normal Serum Electrolytes Levels

NCT ID: NCT06218212

Last Updated: 2024-02-05

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

24 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-02-12

Study Completion Date

2023-06-30

Brief Summary

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This clinical trial will evaluate Renastart formula effectiveness in children with acute kidney injury (AKI) and acute on top of chronic kidney disease (CKD), in maintaining normal serum electrolytes levels without using electrolyte binders,24 patients will be recruited from Pediatric Nephrology Unit (PNU), Children's Hospital, Ain Shams University, they will be assigned randomly in to two arms, arm 1 including patients who will be treated by electrolytes binders, arm 2 including patients who will be treated by Renastart formula, after initial assessment serum electrolyte evaluation will be followed up monthly for 3 months.

Detailed Description

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Conditions

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Acute Kidney Injury

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Arm 1 patients with AKI and acute on top of CKD who will be treated by electrolytes binders.

they will start calcium carbonate (phosphorus binder) with dosage 45-65 mg/kg/day orally with / or sodium polystyrene sulfonate (potassium binder) with dosage 0.5-1mg/kg/day orally.

Group Type ACTIVE_COMPARATOR

calcium carbonate (phosphorus binder) with / or sodium polystyrene sulfonate (potassium binder) with dosage 0.5-1mg/kg/day orally.

Intervention Type DRUG

calcium carbonate (phosphorus binder) in dosage of 45-65 mg/kg/day orally with / or sodium polystyrene sulfonate (potassium binder) in dosage of 0.5-1mg/kg/day orally.

Arm 2 patients with AKI and acute on top of CKD who will be treated by Renastart formula.

* Renastart formula will be used with breast milk, standard infant formula or with diet.
* Preparation: Adding one level scoop of Renastart to 30 ml water.
* Renastart formula will be started to represent ¼ recommended daily allowance of daily caloric intake and the dose will be adjusted according to serum electrolyte levels.

Group Type EXPERIMENTAL

Renastart formula

Intervention Type DIETARY_SUPPLEMENT

* Renastart formula is an artificial formula is made by Vitaflo USA, Nestle Health Science Company.
* Renastart formula preparation: Adding one level scoop of Renastart to 30 ml water.
* Renastart formula will be used with breast milk, standard infant formula, standard pediatric infant feed and/ or mixed with diet.
* Renastart formula dosage will be adjusted to be 1/4 Renastart and 3/4 breast milk, standard infant formula or standard pediatric infant daily caloric feed ratio.
* Readjusting dosage ratio according to serum electrolytes levels especially potassium.

Interventions

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Renastart formula

* Renastart formula is an artificial formula is made by Vitaflo USA, Nestle Health Science Company.
* Renastart formula preparation: Adding one level scoop of Renastart to 30 ml water.
* Renastart formula will be used with breast milk, standard infant formula, standard pediatric infant feed and/ or mixed with diet.
* Renastart formula dosage will be adjusted to be 1/4 Renastart and 3/4 breast milk, standard infant formula or standard pediatric infant daily caloric feed ratio.
* Readjusting dosage ratio according to serum electrolytes levels especially potassium.

Intervention Type DIETARY_SUPPLEMENT

calcium carbonate (phosphorus binder) with / or sodium polystyrene sulfonate (potassium binder) with dosage 0.5-1mg/kg/day orally.

calcium carbonate (phosphorus binder) in dosage of 45-65 mg/kg/day orally with / or sodium polystyrene sulfonate (potassium binder) in dosage of 0.5-1mg/kg/day orally.

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

•Infants and Children with AKI and acute on top of CKD Suffering from hyperkalemia and/or hyperphosphatemia at Pediatric Nephrology Unit (PNU), Children's Hospital, Ain Shams University Hospitals.

Exclusion Criteria

* Patients are on dialysis.
* Pediatric patients with coexisting another medical problems and different risk factors which can affect serum electrolytes such as: Constipation, high volume blood transfusion and Diabetes medications disrupt potassium balance e.g., ACEI, ARBS and Diuretics.
Minimum Eligible Age

1 Month

Maximum Eligible Age

10 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Ain Shams University

OTHER

Sponsor Role lead

Responsible Party

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Haya Essam Ibrahim

lecturer of pediatrics

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Haya E Ibrahim, MD

Role: PRINCIPAL_INVESTIGATOR

lecturer of pediatrics,Faculty of Medicine, Ain shams University

Locations

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Faculty of Medicine-Ain Shams University

Cairo, Abbasia, Egypt

Site Status

Countries

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Egypt

Other Identifiers

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FMASU MS 643/ 2021

Identifier Type: -

Identifier Source: org_study_id

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