High-Risk Metachronous Oligometastatic Prostate Cancer Trial

NCT ID: NCT06212583

Last Updated: 2025-05-01

Basic Information

• Recruitment Status: RECRUITING
• Clinical Phase: PHASE2
• Total Enrollment: 88 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2024-04-17
• Study Completion Date: 2029-12-31

Brief Summary

The purpose of this research study is to compare the effects, good and/or bad, of using the standard of care treatment, hormonal therapy + Stereotactic Ablative Radiation (SABR) to the metastatic lesions, compared to standard of care and addition of 6-months of niraparib/abiraterone acetate combination pills and prednisone for participants with recurrent metastatic prostate cancer.

Detailed Description

In this trial all participants will be randomized to one of the two groups. You will be randomly assigned (by chance, like the flip of a coin) to one of the two groups: 1: Standard of care treatment (hormonal therapy + SABR to the metastatic lesions) or 2: Standard of care treatment + 6-months of niraparib/abiraterone acetate combination pills and prednisone. Participants in both groups will receive rectal swabs and various blood tests to assess circulating tumor cells, genomic sequencing, and tumor markers. Both groups will also participate in quality-of-life surveys

Conditions

Prostate Cancer; Oligometastatic Disease

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Androgen deprivation therapy + Stereotactic ablative radiation

Group Type: ACTIVE_COMPARATOR

Stereotactic ablative radiation therapy (SABR)

Intervention Type: RADIATION

Both arms will receive SABR

Androgen deprivation therapy (ADT)

Intervention Type: DRUG

All ADT is provided as best prescribed for patient per their medical oncologist.

Androgen deprivation therapy + Stereotactic ablative radiation + niraparib/abiraterone acetate

Group Type: ACTIVE_COMPARATOR

niraparib/abiraterone acetate

Intervention Type: DRUG

Patients on Arm 2 to receive drug for 6 months

Stereotactic ablative radiation therapy (SABR)

Intervention Type: RADIATION

Both arms will receive SABR

Androgen deprivation therapy (ADT)

Intervention Type: DRUG

All ADT is provided as best prescribed for patient per their medical oncologist.

Interventions

niraparib/abiraterone acetate

Patients on Arm 2 to receive drug for 6 months

Intervention Type: DRUG

Stereotactic ablative radiation therapy (SABR)

Both arms will receive SABR

Intervention Type: RADIATION

Androgen deprivation therapy (ADT)

All ADT is provided as best prescribed for patient per their medical oncologist.

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

1. ≥18 years of age (or the local legal age of consent).

2. Patient must have at least one and up to three asymptomatic metastatic tumor(s) of the bone, soft tissue, or extra-pelvic nodal region each < 5 cm or < 250 cm3 that develop within the past 6-months that are seen on imaging. A nodal lesion is defined to include nodal conglomerates located in the same nodal chain such that they can be treated in one SABR field. Up to five lesions are allowed on advanced functional imaging such as fluciclovine (Axumin), choline or Prostate Specific Membrane Antigen (PSMA) PET-CT scan.

1. CT or MRI scan within 6 months of enrollment

2. Bone scan within 6 months of enrollment

3. Fluciclovine (Axumin), choline, or PSMA PET-CT scan within 6 months of enrollment (PET-CT scan is reasonable for study entry imaging as an alternative to CT/MRI scan and bone scan)

3. Must have a high-risk pathogenic mutation (TP53, BRCA1/2, PALB2, ATM, BRIP1, CHEK2, FANCA, RAD51B, RAD54L, MUTYH) by next generation sequencing. ATM mutation enrollment will be capped at 5% of the overall population.

4. Histologic confirmation of prostate adenocarcinoma (primary or metastatic tumor).

5. Patient may have had prior systemic therapy and/or ADT so long as testosterone is > 100 ng/dl prior to enrollment

6. PSA > 0.5 but <50 at enrollment.

7. Prostate Specific Antigen Doubling Time (PSADT) < 15 months

8. Baseline testosterone > 100 ng/dl

9. Patient must have a life expectancy ≥ 12 months.

10. Patient must have an ECOG performance status ≤ 2.

11. Adequate hematologic, renal, and hepatic function at screening defined as follows:

• Absolute neutrophil count ≥1.5 x 109/L

• Hemoglobin ≥9.0 g/dL, independent of transfusions for at least 28 days
• Platelet count ≥100 x 109/L
• Creatinine <2 x upper limit of normal (ULN)
• Serum potassium ≥3.5 mmol/L
• Serum total bilirubin ≤1.5× ULN or direct bilirubin ≤1 x ULN (Note: In participants with Gilbert's syndrome, if total bilirubin is >1.5 × ULN, measure direct and indirect bilirubin, and if direct bilirubin is ≤1.5 × ULN, participant may be eligible)
• AST or ALT ≤3 × ULN

12. Patient must have the ability to understand and the willingness to sign a written informed consent document

13. Able to swallow the study medication tablets whole.

14. While on study medication and for 4 months following the last dose of study medication, a male participant must agree to use condom and an adequate contraception method for female partner (WOCBP) A male participant must agree not to donate sperm while on study treatment and for a minimum of 4 months following the last dose of study medication.

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1. Castration-resistant prostate cancer (CRPC).

2. Prior radiation therapy to an overlapping site of a target lesion that would preclude further radiation therapy

3. Spinal cord compression or impending spinal cord compression.

4. Suspected intracranial and/or liver metastases (>10 mm in largest axis).

5. Patient receiving any other investigational agents.

6. Inability to receive any form of systemic therapy in the opinion of a treating medical oncologist.

7. Unable to lie flat during or tolerate PET/MRI, PET/CT or SABR.

8. Radiographical evidence of cranial parenchymal metastasis.

9. Active second primary malignancy; AML/MDS in medical history.

10. Uncontrolled hypertension and myocardial infarction/PE/cardiac failure in last 6 months.

11. Prior treatment with PARP inhibitor

12. Refusal to sign informed consent.

13. Pathological finding consistent with small cell or neuroendocrine carcinoma of the prostate.

14. History of adrenal dysfunction

15. Long-term use of systemically administered corticosteroids (>5mg of prednisone or the equivalent) during the study is not allowed. Short-term use (≤4 weeks, including taper) and locally administered steroids (eg, inhaled, topical, ophthalmic, and intra-articular) are allowed, if clinically indicated.

16. Active malignancies (ie, progressing or requiring treatment change in the last 24 months) other than the disease being treated under study. The only allowed exceptions are:

• non-muscle invasive bladder cancer.
• skin cancer (non-melanoma or melanoma) treated within the last 24 months that is considered completely cured.
• malignancy that is considered cured with minimal risk of recurrence.
• History or current diagnosis of MDS/AML.

17. Current evidence within 6 months prior to randomization of any of the following:

• severe/unstable angina, myocardial infarction, symptomatic congestive heart failure,

• clinically significant arterial or venous thromboembolic events (ie. Pulmonary embolism), or clinically significant ventricular arrhythmias.

18. Presence of sustained uncontrolled hypertension (systolic blood pressure >160 mm Hg or diastolic blood pressure >100 mm Hg). Participants with a history of hypertension are allowed, provided that blood pressure is controlled to within these limits by an antihypertensive treatment.

19. Known allergies, hypersensitivity, or intolerance to the excipients of niraparib/abiraterone acetate tablets

20. Current evidence of any medical condition that would make prednisone use contraindicated.

21. Received an investigational intervention (including investigational vaccines) or used an invasive investigational medical device within 30 days before the planned first dose of study medication.

22. Participants who have had the following ≤28 days prior to randomization:

• A transfusion (platelets or red blood cells);

• Hematopoietic growth factors;

• Major surgery

23. Human immunodeficiency virus positive participants with 1 or more of the following:

• Not receiving highly active antiretroviral therapy or on antiretroviral therapy for less than 4 weeks.
• Receiving antiretroviral therapy that may interfere with the study medication
• CD4 count <350 at screening.
• An acquired immunodeficiency syndrome-defining opportunistic infection within 6 months of the start of screening.
• Human immunodeficiency virus load >400 copies/mL

24. Active or symptomatic viral hepatitis or chronic liver disease; encephalopathy, ascites or bleeding disorders secondary to hepatic dysfunction.

25. Moderate or severe hepatic impairment (Class B and C per Child-Pugh classification system.

• Minimum Eligible Age: 18 Years
• Eligible Sex: MALE
• Accepts Healthy Volunteers: No

Sponsors

Janssen Scientific Affairs, LLC

INDUSTRY

Sponsor Role: collaborator

University of Maryland, Baltimore

OTHER

Sponsor Role: lead

Responsible Party

Jason Molitoris, MD PhD

Principal Investigator

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

University of Maryland Greenebaum Cancer Center

Baltimore, Maryland, United States

Site Status: RECRUITING

Countries

United States

Central Contacts

Phuoc Tran, MD

Role: CONTACT

phuoc.tran@umm.edu

410-328-6080

Caitlin Eggleston

Role: CONTACT

caitlineggleston@umm.edu

410-328-7586

Facility Contacts

Phuoc Tran, MD

Role: primary

410-328-6080

Caitlin Eggleston

Role: backup

410-328-7586

Other Identifiers

GCC 23100

Identifier Type: OTHER

Identifier Source: secondary_id

HP-00108148

Identifier Type: -

Identifier Source: org_study_id