A Long-term Follow-up Study of Subjects Who Received CRISPR CAR T Cellular Therapies

NCT ID: NCT06208878

Last Updated: 2025-08-14

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

ENROLLING_BY_INVITATION

Total Enrollment

70 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-11-22

Study Completion Date

2038-08-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

This study will evaluate the long-term safety and efficacy of CRISPR CAR T cellular therapies

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

All subjects with hematological and solid malignancies who are enrolled in a parent study and were exposed to allogeneic CRISPR CAR T cellular therapy will be asked to participate in this long-term follow-up (LTFU) study. Subjects who have completed the parent study for the protocol-defined duration, or who have discontinued the parent study early, or who are in secondary follow-up (follow up of subjects with progressive disease or who receive a subsequent line of anticancer therapy) in the parent study may enroll in this LTFU study. This will allow for collection of long-term efficacy data (as applicable) and safety data up to 15 years post-treatment with CRISPR CAR T cellular therapies.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Hematologic Malignancy Solid Malignancy

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Non Interventional

All subjects with hematological and solid malignancies who are enrolled in a parent study and were exposed to allogeneic CRISPR CAR T cellular therapy will be asked to participate in this long-term follow-up (LTFU) study.

Non Interventional

Intervention Type OTHER

Safety and Efficacy Assessment

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Non Interventional

Safety and Efficacy Assessment

Intervention Type OTHER

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Able to understand and comply with protocol-required study procedures and voluntarily sign and date a written informed consent document.
* Must have received CRISPR CAR T cellular therapy.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

CRISPR Therapeutics AG

INDUSTRY

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Responsibility Role SPONSOR

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

City of Hope

Duarte, California, United States

Site Status

Cedars Sinai

Los Angeles, California, United States

Site Status

Stanford

Stanford, California, United States

Site Status

Yale New Haven Hospital

New Haven, Connecticut, United States

Site Status

Emory

Atlanta, Georgia, United States

Site Status

University of Chicago

Chicago, Illinois, United States

Site Status

University of Kansas

Westwood, Kansas, United States

Site Status

University of Minnesota

Minneapolis, Minnesota, United States

Site Status

Washington University Saint Louis

St Louis, Missouri, United States

Site Status

MSKCC

New York, New York, United States

Site Status

Montefiore Medical Center

The Bronx, New York, United States

Site Status

Oregon Health and Science University

Portland, Oregon, United States

Site Status

University of Pennsylvania

Philadelphia, Pennsylvania, United States

Site Status

UT Southwestern

Dallas, Texas, United States

Site Status

MD Anderson Cancer Center

Houston, Texas, United States

Site Status

Methodist Hospital-Sarah Cannon

San Antonio, Texas, United States

Site Status

University of Utah-Huntsman Cancer Institute

Salt Lake City, Utah, United States

Site Status

Royal Prince Alfred Hospital

Camperdown, New South Wales, Australia

Site Status

Peter MacCallum Cancer Center

Melbourne, Victoria, Australia

Site Status

Sir Charles Gairdner

Nedlands, , Australia

Site Status

Princess Margaret

Toronto, Ontario, Canada

Site Status

University Hospital Hamburg-Eppendorf

Hamburg, , Germany

Site Status

Countries

Review the countries where the study has at least one active or historical site.

United States Australia Canada Germany

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

CRSP-ONC-LTF

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.

CART-EGFR-IL13Ra2 in EGFR Amplified Recurrent GBM
NCT05168423 ACTIVE_NOT_RECRUITING PHASE1
GD2/CD70 Bi-specific CAR-T Cell Therapy
NCT05438368 RECRUITING PHASE1/PHASE2
DLL3 CAR-T Therapy Targeting Brain Tumors
NCT07180927 RECRUITING PHASE1/PHASE2
CAR-T Cells Targeting Autoimmune Diseases
NCT05459870 RECRUITING PHASE1/PHASE2