Creatine and Ubiquinol for Sperm Quality

NCT ID: NCT06202469

Last Updated: 2024-12-04

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

18 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-12-15

Study Completion Date

2024-06-30

Brief Summary

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This randomized controlled double-blind parallel-group interventional trial explores the impact of 8-week creatine supplementation, with or without ubiquinol, on sperm quality biomarkers in normospermic and oligospermic men. It aims to determine potential enhancements in sperm health to provide insights into male fertility and reproductive health improvement strategies.

Detailed Description

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Conditions

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Oligospermia Sperm Count, Low

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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Supplement 1

Creatine monohydrate

Group Type EXPERIMENTAL

Supplement 1

Intervention Type DIETARY_SUPPLEMENT

Creatine monohydrate (5 g/day)

Supplement 2

Creatine monohydrate plus ubiquinol

Group Type EXPERIMENTAL

Supplement 2

Intervention Type DIETARY_SUPPLEMENT

Creatine monohydrate (5 g/day) plus ubiquinol (200 mg/day)

Placebo

Inulin

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DIETARY_SUPPLEMENT

Placebo (inulin)

Interventions

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Supplement 1

Creatine monohydrate (5 g/day)

Intervention Type DIETARY_SUPPLEMENT

Supplement 2

Creatine monohydrate (5 g/day) plus ubiquinol (200 mg/day)

Intervention Type DIETARY_SUPPLEMENT

Placebo

Placebo (inulin)

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

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Inclusion Criteria

* Age 18 - 35 years
* Sperm quality test available (at least half will have low sperm quality)
* Informed consent
* Healthy BMI (18.5 - 24.9 kg/m2)

Exclusion Criteria

* Major chronic disease and acute injuries
* History of dietary supplement use during the past 28 days
* No consent to randomization
* Participation in other studies
Minimum Eligible Age

18 Years

Maximum Eligible Age

35 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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University of Novi Sad, Faculty of Sport and Physical Education

OTHER

Sponsor Role lead

Responsible Party

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Sergej Ostojic

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Sergej Ostojic, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

University of Novi Sad

Locations

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FSPE Applied Bioenergetics Lab

Novi Sad, Vojvodina, Serbia

Site Status

Countries

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Serbia

References

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Ostojic SM, Stea TH, Engeset D. Creatine as a Promising Component of Paternal Preconception Diet. Nutrients. 2022 Jan 28;14(3):586. doi: 10.3390/nu14030586.

Reference Type BACKGROUND
PMID: 35276945 (View on PubMed)

Nedeljkovic D, Todorovic N, Javorac D, Baltic S, Vranes M, Panic J, Kladar N, Ratgeber L, Betlehem J, Acs P, Stea TH, Engeset D, Stajer V, Ostojic SM. The effects of 8-week creatine supplementation with and without ubiquinol on sperm quality biomarkers in normospermic and oligospermic men: A randomized controlled pilot trial. Nutr Health. 2025 Oct 6:2601060251385000. doi: 10.1177/02601060251385000. Online ahead of print.

Reference Type DERIVED
PMID: 41052075 (View on PubMed)

Other Identifiers

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CR-24-AK15

Identifier Type: -

Identifier Source: org_study_id