Towards a Sex-specific "Female Enhanced Recovery After Cardiac Surgery'' (F-ERAS) Pathway:

NCT ID: NCT06175650

Last Updated: 2023-12-19

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

5500 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-11-21

Study Completion Date

2026-11-21

Brief Summary

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The aim of this study is to evaluate the differences between men and women undergoing cardiac surgery. We will look at perioperative factors such as body weight, body surface area, previous medical history, pharmacokinetics, transfusion, coagulation, cardiopulmonary bypass (CPB) related factors, cardiac function, inotropic requirements, risk, and outcome scores as well as morbidity and mortality at 30 and 90 days, 1, 5, and 10 years.

Detailed Description

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Observational, multicentre, retrospective data collection from the mandatory Quality Assurance database (the Netherlands Heart Registry, (NHR), supplemented with data from the electronic patient files (EPIC). The retrospective data is already available.

In addition, we will continue the retrospective study into a prospective registry of data after the analysis of the retrospective data. Patients will be approached one, five and ten years after the operation and a questionnaire will be sent to document quality of life. No research-related interventions other than questionnaires will be performed

Conditions

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Female Male Surgery,Cardiac

Keywords

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Anesthesia Quality of Life

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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Female

Female patients undergoing cardiac surgery

Cardiac surgery

Intervention Type PROCEDURE

Cardiac surgery of all types

Male

Male patients undergoing cardiac surgery

Cardiac surgery

Intervention Type PROCEDURE

Cardiac surgery of all types

Interventions

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Cardiac surgery

Cardiac surgery of all types

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Patients \> 18 years
* All patients who underwent cardiac surgery from 1 January 2016 to the start of the study, in either of the centres (AMC or VUmc) (retrospective)
* All patients undergoing cardiac surgery from the start of the study (\~March 2022) until approximately 2032

Exclusion Criteria

• Patients who object to the re-use of their care data or do not give consent
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Jennifer Breel

OTHER

Sponsor Role lead

Responsible Party

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Jennifer Breel

Investigator

Responsibility Role SPONSOR_INVESTIGATOR

Principal Investigators

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Markus W Hollmann, Professor

Role: PRINCIPAL_INVESTIGATOR

Anesthesiology and Pain Medicine, Amsterdam Medical Center

Locations

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Academic Medical Center

Amsterdam, North Holland, Netherlands

Site Status RECRUITING

Countries

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Netherlands

Central Contacts

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Jennifer S Breel, MSc

Role: CONTACT

Phone: +31610019257

Email: [email protected]

Susanne Eberl, PhD

Role: CONTACT

Phone: +31610019257

Email: [email protected]

Facility Contacts

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Jennifer S Breel, MPA,MSc.

Role: primary

Susanne Eberl, MD, PhD

Role: backup

References

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Cho L, Kibbe MR, Bakaeen F, Aggarwal NR, Davis MB, Karmalou T, Lawton JS, Ouzounian M, Preventza O, Russo AM, Shroyer AW, Zwischenberger BA, Lindley KJ. Cardiac Surgery in Women in the Current Era: What Are the Gaps in Care? Circulation. 2021 Oct 5;144(14):1172-1185. doi: 10.1161/CIRCULATIONAHA.121.056025. Epub 2021 Oct 4.

Reference Type BACKGROUND
PMID: 34606298 (View on PubMed)

Dixon LK, Di Tommaso E, Dimagli A, Sinha S, Sandhu M, Benedetto U, Angelini GD. Impact of sex on outcomes after cardiac surgery: A systematic review and meta-analysis. Int J Cardiol. 2021 Nov 15;343:27-34. doi: 10.1016/j.ijcard.2021.09.011. Epub 2021 Sep 11.

Reference Type BACKGROUND
PMID: 34520795 (View on PubMed)

Nanegrungsunk D, Patel S, Jan T, Ngai JY. Preoperative Care Practice for Female Cardiac Patients: A Survey From the Society of Cardiovascular Anesthesiologists. J Cardiothorac Vasc Anesth. 2022 Mar;36(3):920-921. doi: 10.1053/j.jvca.2021.09.054. Epub 2021 Oct 3. No abstract available.

Reference Type BACKGROUND
PMID: 34776353 (View on PubMed)

Peters SAE, Kluin J. Why do women do worse after coronary artery bypass grafting? Eur Heart J. 2021 Dec 28;43(1):29-31. doi: 10.1093/eurheartj/ehab617. No abstract available.

Reference Type BACKGROUND
PMID: 34524421 (View on PubMed)

Other Identifiers

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W22_051 # 22.082

Identifier Type: -

Identifier Source: org_study_id