Infectious Prospective Collection for Biological Analysis

NCT ID: NCT06159270

Last Updated: 2023-12-06

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

22870 participants

Study Classification

OBSERVATIONAL

Study Start Date

2019-05-18

Study Completion Date

2025-05-18

Brief Summary

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The increase in activity within medical biology laboratories linked to the arrival of new markers (in cardiology, oncology, infectious diseases, etc.) and the acceleration of technical progress have created a prominent place for automated systems and their reagent kits within these establishments.

It is in this context that CerbaXpert took the initiative to set up this research project for the collection of prospective biological samples and their analysis. It transcribes both a process of continuous improvement but also scientific development, making it possible to provide new and/or complementary data in order to improve the operation of automated systems and their reagents within medical biology laboratories. These data obtained in current practice via this study will also be compared with the technical information provided by the manufacturers of the reagents and their automatic devices.

Detailed Description

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This research protocol is a prospective multicenter collection of biological samples for evaluation of reagents and automated systems on the following parameters: HAV, B, C, D and E, HIV, HBV, EBV, CMV, VZV, HPV, HSV, polyomavirus family, Chlamydia Trachomatis, Neisseria gonorrhoeae, Mycoplasma genitalium, Trichomonas vaginalis, Treponema pallidum, Zika virus, dengue fever, chikungunya virus, influenza virus, Mycobacterium tuberculosis bacteria, parasite responsible for toxoplasmosis, malaria, rubella virus, Lyme borreliosis Sars-CoV-2 virus responsible for Covid-19 disease, bacteria responsible for leptospirosis and salmonellosis, the pathogens responsible for sepsis (viruses, bacteria or fungus) and finally the Poxiviridae family. This research is categorized as Research Involving Human Person level 3 (RIPH 3), that is to say non-interventional, carried out in current medical practice. Recruitment will include a maximum of 22870 samples belonging to the following groups: population general (ambulatory patients, hospitalized patients, pregnant women, dialysis patients) and known population carrying the desired infectious agent.

This protocol does not include special procedure for allocation or differential treatment for the subjects included: there is neither randomization or treatment assigned to people participating in the study.

The subjects recruited will be within several survey sites spread across the national territory: the Cerballiance medical biology laboratories, belonging to the Cerba HealthCare group. Some clinical sites can be managed via a centralized collection site, where a person is designated as principal investigator after qualification by the promoter and authorization from the Committee of Protection of People.

Information relating to age, sex, date and place of sampling, sample population of each subject (general patients, hospitalized patients, pregnant women, dialysis patients or patients known positive for one of the infectious agents targeted by this research protocol) will be also varied. Relevant medical data may also be compiled:

1. the genotype of HAV, B, C, D and E, HIV, HBV (if available);
2. the stage of the disease (acute, chronic, cured);
3. concomitant treatments linked to the pathology (if available) or which may interfere with the planned analysis.
4. data relating to the participant's lifestyle.
5. date of onset of symptoms, date of PCR test if applicable, vaccination status, date of vaccination, name of vaccine, number of injections, batch number of vaccine.

Conditions

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Infectious Disease

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Cohort of patients presenting infectious diseases

Blood sample

Intervention Type OTHER

Venuous blood sampling

Interventions

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Blood sample

Venuous blood sampling

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* All-comers clinical subjects (ambulatory)
* Hospitalized patients
* Pregnant women (all comers)
* Subjects on dialysis
* Known subjects positive for targeted pathogens

Exclusion Criteria

* Subject having already participated in this protocol within 15 days previous ones.
* Subject having received medication or treatment experimental or investigational during the last four weeks before collection
* Person subject to a judicial safeguard measure
* Person not affiliated to the Social Security system and not not having social security coverage
Minimum Eligible Age

18 Years

Maximum Eligible Age

88 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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CerbaXpert

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Barbara Pernicni, Dr

Role: STUDY_DIRECTOR

Cerba Xpert

Locations

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Cerba Xpert

Saint-Ouen-l'Aumône, , France

Site Status RECRUITING

Countries

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France

Central Contacts

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Barbara Perniconi, Dr

Role: CONTACT

Phone: 0142657831

Email: [email protected]

Guillaume Franc

Role: CONTACT

Phone: 0142657831

Email: [email protected]

Facility Contacts

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Barbara Perniconi, Dr

Role: primary

Other Identifiers

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Infectieux 1

Identifier Type: -

Identifier Source: org_study_id