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Predicting Rectal Adenoma With Canceration and Investigating Mechanism Based on Multimodal MRI and Biochemical Model

NCT ID: NCT06158776

Last Updated: 2023-12-06

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

100 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-01-01

Study Completion Date

2022-06-15

Brief Summary

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In this retrospective study is to establish a diagnostic model for rectal adenoma canceration. The model will include multimodal comprehensive HR-T2WI morphological score, IVIM functional imaging and radiomics features, and clinical indicators such as tumor markers, serum Gelsolin protein and peripheral blood inflammatory cell ratio. It can be to provide accurate diagnostic information for patients before surgery, which is of great value for formulating personalized treatment plans and improving the prognosis of patients.

Detailed Description

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Imaging tests is the main method for evaluating rectal mass, especially MRI, which has been widely used in the preoperative diagnosis of rectal mass disease due to its very good soft tissue resolution. Previous studies in our group found that HR-T2WI-based radiomics, HR-T2WI-based morphology, and IVIM-based functional imaging can be used for the diagnosis of adenoma canceration. In addition to imaging, other tests, such as peripheral blood tests, can also reflect the development and progression of adenocarcinoma by counting tumor markers (colorectal tumor markers mainly CEA, AFP, CA199, CA724, CA50, CA242), inflammatory cell ratio (lymphocyte/C-reactive protein ratio, neutrophil/lymphocyte ratio, lymphocyte/monocytes ratio), and special types of proteins (such as coagulant protein).This study identifies the progression of adenoma to carcinoma by analyzing the combined cellular, morphological, and functional changes in adenoma carcinomas, with the expectation that multimodal co-diagnosis will improve the accuracy of clinical diagnosis.

Conditions

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Rectal Adenoma

Keywords

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Rectal Adenoma;Canceration;Magnetic resonance imaging Radiomics

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

RETROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

1. surgical resection
2. pathologically confirmed rectal adenoma or rectal adenoma with canceration
3. rectal MRI examination including IVIM-DWI, within two weeks before surgery

Exclusion Criteria

1. preoperative treatment
2. poor image quality, including intestinal gas or fecal artifact and IVIM image fitting error
3. no surgical resection but colonoscopy
4. pathologically confirmed rectal cancer.
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Aiyin Li

OTHER

Sponsor Role lead

Responsible Party

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Aiyin Li

professor

Responsibility Role SPONSOR_INVESTIGATOR

Principal Investigators

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Aiyin Li, Ph.D.

Role: STUDY_DIRECTOR

Qianfoshan Hospital

Locations

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Qianfoshan Hosptial

Jinan, Shandong, China

Site Status

Countries

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China

Other Identifiers

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S1119

Identifier Type: -

Identifier Source: org_study_id