Effect of Ultrasound Combined With Microbubbles on Blood Perfusion in Invasive Breast Cancer

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

30 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-09-29

Study Completion Date

2025-05-06

Brief Summary

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Blood perfusion insufficiency and hypoxia are the main causes of drug resistance to chemotherapy in breast cancer. Increasing blood perfusion can improve drug delivery. The cavitation effect of ultrasound-stimulated microbubbles (USMBs) is known to enhance tumor blood perfusion, so we conducted a prospective human study to investigate the effects of USMBs on hemoperfusion in invasive breast cancer (IBC).

Detailed Description

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patients with IBC were selected from the breast surgery department of our hospital. To induce an enhanced perfusion effect, IBC tumors were treated with SonoVue® microbubbles (MBs) stimulated by ultrasound, with a mechanical index (MI) of 0.2-0.3; 1 mL of SonoVue® MBs were injected at 3.5-min intervals three times for a USMB treatment lasting 10 min. The contrast-enhanced ultrasound (CEUS) parameters peak intensity (PI), area under the curve (AUC), and perfusion area were used to evaluate the changes in blood perfusion.

Conditions

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Invasive Breast Cancer Cavitation Perfusion

Keywords

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Contrast-enhanced ultrasound ultrasound combined with microbubbles Invasive ductal carcinoma of breast

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Interventions

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ultrasound combined with microbubbles

IBC tumors were treated with microbubbles (MBs) stimulated by ultrasound

Intervention Type PROCEDURE

Other Intervention Names

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Cavitation effect Microbubble assisted ultrasound technique

Eligibility Criteria

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Inclusion Criteria

* Clinical diagnosis of Invasive Breast Cancer
* patients scheduled to undergo surgical resection
* maximum lesion diameter \< 4 cm
* age over 18 years

Exclusion Criteria

* patients with allergies to SonoVue®
* patients with severe cardiopulmonary insufficiency,
* patients who had already received neoadjuvant chemotherapy
* pregnant women
* individuals with mental illness
* Patients who refused to participate in the study

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Responsible Party

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Responsibility Role SPONSOR

Locations

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Beijing Friendship Hospital, Capital Medical University

Beijing, , China

Site Status RECRUITING

Countries

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China

Central Contacts

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Yunyun Dong, MS

Role: CONTACT

Phone: 01063138576

Email: [email protected]

Facility Contacts

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Yunyun Dong

Role: primary

Other Identifiers

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MR-11-22-009539

Identifier Type: -

Identifier Source: org_study_id