Evaluation of VQm PHM on Pulmonary Health Parameters for ICU

NCT ID: NCT06147674

Last Updated: 2023-11-27

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Total Enrollment

150 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-01-15

Study Completion Date

2025-03-31

Brief Summary

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The goal of this observational study is to compare pulmonary health parameter measurements from the VQm PHM™ to existing clinical measurements. The main questions it aims to answer are:

* Confirm the performance of non-invasive pulmonary health parameter shunt fraction value found on the VQm PHM™ when compared to available reference measurements.
* Confirm the performance of non-invasive pulmonary health parameter pulmonary blood flow, functional residual capacity and physiological dead space found on the VQm PHM™ when compared to available reference measurements.

Detailed Description

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This is a multi-site, international, prospective, non-blinded, non-randomized, observational study. This study aims to compare measurements from the VQm PHM™ to existing clinical measurements, assess safety of the device and determine effects that standard clinical events have on the VQm PHM™ measurements. This study does not include changes to clinical care based on measurements from the VQm PHM™. Each patient will serve as their own control.

Conditions

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Ventilators, Mechanical Stroke COPD Acute Lung Injury/Acute Respiratory Distress Syndrome (ARDS) Pneumonia

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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VQm PHM™

Non-invasive measurements obtained with the VQm PHM™ compared to current standard of care.

VQm Pulmonary Health Monitor™

Intervention Type DEVICE

The VQm Pulmonary Health Monitor™ (may be referred to as the VQm PHM™) is a a Class IIa, Health Canada approved medical device used as an adjunct monitor and is non-life supporting, providing clinicians with measurements of pulmonary function parameters of mechanically ventilated adult patients. The measurements provided are:

* Pulmonary Blood Flow (PBF)
* Shunt Fraction (Qsi)
* Dead space (VD):
* Functional Residual Capacity (FRC)

Interventions

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VQm Pulmonary Health Monitor™

The VQm Pulmonary Health Monitor™ (may be referred to as the VQm PHM™) is a a Class IIa, Health Canada approved medical device used as an adjunct monitor and is non-life supporting, providing clinicians with measurements of pulmonary function parameters of mechanically ventilated adult patients. The measurements provided are:

* Pulmonary Blood Flow (PBF)
* Shunt Fraction (Qsi)
* Dead space (VD):
* Functional Residual Capacity (FRC)

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Male or female 18 years old or above, at the time of the inclusion
* Patient currently admitted in the ICU, who are indicated for cardiac output monitoring using a pulmonary artery catheter and who require pressure or volume controlled mechanical ventilation using an ETT
* Provision of signed and dated informed consent form (ICF) by the patient or a trusted person

Exclusion Criteria

* Male or female under the age of 18 years old, at the time of screening
* Patient under guardianship
* Patient who requires tidal volumes of less than 250cc
* Pregnancy
* Patient whose care requires the use of an anesthetic conserving device
* Patient whose care requires a closed-loop ventilator
* Patient who is unable to tolerate a transient increase in inhaled CO2
* Patient who is unable to tolerate a transient inhalation of N2O or is contraindicated to N2O use
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Medical Initiatives

NETWORK

Sponsor Role collaborator

Rostrum Medical Innovations Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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UC Davis Medical Center

Sacramento, California, United States

Site Status

Medical University of Vienna

Vienna, , Austria

Site Status

University Hospital Kralovske Vinohrady

Prague, , Czechia

Site Status

Hôpital Européen Georges Pompidou

Paris, , France

Site Status

Countries

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United States Austria Czechia France

Central Contacts

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Nathan Ayoubi

Role: CONTACT

604-439-3054

Scott Alexander, MBBS

Role: CONTACT

Facility Contacts

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Neal W Flemming, M.D., Ph.D.

Role: primary

916-734-5394

Maximilian Edlinger-Stanger, M.D.

Role: primary

+43 1 4016056515

Frantisek Duska, M.D.

Role: primary

+421 2/671 637 78

Bernard P Cholley, M.D., Ph.D.

Role: primary

+33 1 56 09 20 00

Other Identifiers

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LM02-CLR-0002

Identifier Type: -

Identifier Source: org_study_id