THE EFFECT OF VITAMIN C ON POST-ORTHODONTIC TREATMENT RELAPSE
NCT ID: NCT06146296
Last Updated: 2023-11-24
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
PHASE2/PHASE3
36 participants
INTERVENTIONAL
2023-11-01
2024-06-01
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
SUPPORTIVE_CARE
SINGLE
Study Groups
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Intra-epidermal Vitamin C injection
Local Vitamin C injection
An injection of 1-1.5 ml of L-ascorbic acid, locally introduced in relation to the keratinized gingival tissues, with extension to the whole target region successively. The injected area will be massaged for equal distribution of the injected vitamin. Injections will be performed on the first day of retainer delivery (T0), after 1 month (T1), after 3 months (T2), and after 6 months (T3). Hence, a total of 4 local Vit-C injections will be performed over the study period.
Oral Vit-C supplement
Oral Vitamin C supplement
Patients will be prescribed a daily oral (systemic) Vit-C supplement to be taken over the follow up period.
Control group
No interventions assigned to this group
Interventions
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Local Vitamin C injection
An injection of 1-1.5 ml of L-ascorbic acid, locally introduced in relation to the keratinized gingival tissues, with extension to the whole target region successively. The injected area will be massaged for equal distribution of the injected vitamin. Injections will be performed on the first day of retainer delivery (T0), after 1 month (T1), after 3 months (T2), and after 6 months (T3). Hence, a total of 4 local Vit-C injections will be performed over the study period.
Oral Vitamin C supplement
Patients will be prescribed a daily oral (systemic) Vit-C supplement to be taken over the follow up period.
Eligibility Criteria
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Inclusion Criteria
* Adult patients with finished orthodontic treatment, using fixed appliance therapy.
* Patients with good oral hygiene, and a healthy periodontal condition.
Exclusion Criteria
* Patients with hypodontia requiring tooth replacement in the retainer, as a temporary measure.
* Patients requiring fixed bonded retainers.
* Pregnant and lactating women.
* Patients with hereditary hemochromatosis.
* Cancer patients, receiving chemotherapy.
* Patients with chronic diseases such as diabetes, or those receiving drugs such as corticosteroids, both of which that may affect tooth movement.
19 Years
25 Years
ALL
No
Sponsors
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Nourhan M.Aly
OTHER
Responsible Party
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Nourhan M.Aly
Assistant Lecturer of Dental Public Health
Principal Investigators
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Samar M Adel, PhD
Role: PRINCIPAL_INVESTIGATOR
Alexandria University
Farah Y Eid, PhD
Role: PRINCIPAL_INVESTIGATOR
Alexandria University
Locations
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Faculty of Dentistry, Alexandria University
Alexandria, , Egypt
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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#10/23
Identifier Type: -
Identifier Source: org_study_id