Chlorhexidine Gel Versus Alvogyl Following Surgical Extraction of Impacted Mandibular Third Molar
NCT ID: NCT06144983
Last Updated: 2023-11-22
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
PHASE4
51 participants
INTERVENTIONAL
2022-02-01
2022-09-01
Brief Summary
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To the best of our knowledge, few clinical researchers have investigated the effect of local application of Alvogyl paste and Chlorhexidine gel, in the management of pain, facial swelling, and trismus resulting from lower third molar surgical extraction.
Aim of the study: The study was meant to compare the effects of 0.2% chlorhexidine gel and Alvogyl paste on the reduction of the inflammatory reaction caused by the surgical extraction of the impacted mandibular third molar, which includes pain, facial swelling, and trismus.
Detailed Description
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Aim of the study: The study was meant to compare the effects of 0.2% chlorhexidine gel and Alvogyl paste on the reduction of the inflammatory reaction caused by the surgical extraction of the impacted mandibular third molar, which includes pain, facial swelling, and trismus.
Materials and Methods: This randomized control study was conducted from February 2022 to September 2022 on (51) patients, (23) male and (28) female, aged (18-39) years, who presented with impacted mandibular third molar. The participants were randomly allocated into three groups, 17 patients received Alvogyl paste (G1), 17 patients received 0.2% Chlorhexidine gel (Periokin) (G2), and 17 patients received nothing upon surgery (G3). The mouth opening and facial measurements were assessed preoperatively as a baseline reference and on the 2nd and 7th postoperative days. pain was assessed daily using a numerical rating scale (NRS) from the first day to the seventh day following surgery.
Results: Regarding the mouth opening, there was no statistically significant difference among the three groups in the degree of trismus on the second and seventh postoperative days (P ≥ 0.05).
In regards to postoperative facial edema and pain, there was a statistically significant difference among all groups (P \< 0.05), however, there was no statistically significant difference between the two study groups.
Conclusion: This study showed that Alvogyl paste and 0.2% Chlorhexidine bioadhesive gel significantly reduce postoperative pain and facial swelling with no significant effect on trismus following impacted mandibular third molar surgical extraction.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
SINGLE
Study Groups
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Alvogyl paste
Application of 0.2 gm of Alvogyl paste inside the extraction socket filling it entirely, and suturing the flap interrupted suture following impacted mandibular third molar surgery.
Alvogyl
In the first study group, (0.2gm) of Alvogyl paste (Septodont Inc., France), was inserted inside the alveolus, filling it entirely
Cholrhexidine gel
Application of 1 ml of Chlorhexidine gel inside the extraction socket filling it entirely, and suturing the flap interrupted suture following impacted mandibular third molar surgery.
Chlorhexidine Gluconate
in the second group (1ml) of Periokin (Kin Inc., Spain), containing 0.2% Chlorhexidine bioadhesive gel was injected to fill the entire socket
control
no dressing material was applied following the impacted mandibular third molar surgery.
No interventions assigned to this group
Interventions
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Alvogyl
In the first study group, (0.2gm) of Alvogyl paste (Septodont Inc., France), was inserted inside the alveolus, filling it entirely
Chlorhexidine Gluconate
in the second group (1ml) of Periokin (Kin Inc., Spain), containing 0.2% Chlorhexidine bioadhesive gel was injected to fill the entire socket
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
2. No history of recently using anti-inflammatory drugs.
3. Patients aged ≥18 years who were indicated for surgical extraction of mesioangular, class I or II, and position A or B impacted mandibular third molar.
4. Well-educated patients who had no objection to take part in the study and likely to comply with all study procedures.
Exclusion Criteria
2. Recent history of head and neck radiotherapy.
3. Pregnancy, and female patients taking contraceptives.
4. Patients with severe localized infections in relation to the third molar, such as Pericoronitis, or those with severe periodontal disease and/or poor oral hygiene.
5. Patients who were unable to come back for follow-up and recall appointments.
6. Impacted third molar that interferes with the inferior alveolar nerve.
7. Periapical pathology or cystic lesions related to the impacted tooth.
8. Heavy smokers (more than 20 cigarettes/day).
18 Years
ALL
Yes
Sponsors
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University of Baghdad
OTHER
Responsible Party
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Abdul Haleem Alaa Abdul Zahra
B.D.S
Principal Investigators
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Sahar sh Aladili, B.D.S.MS.C
Role: STUDY_DIRECTOR
University of Baghdad
Locations
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University of Baghdad
Baghdad, , Iraq
Countries
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References
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Jesudasan JS, Wahab PU, Sekhar MR. Effectiveness of 0.2% chlorhexidine gel and a eugenol-based paste on postoperative alveolar osteitis in patients having third molars extracted: a randomised controlled clinical trial. Br J Oral Maxillofac Surg. 2015 Nov;53(9):826-30. doi: 10.1016/j.bjoms.2015.06.022. Epub 2015 Jul 16.
Other Identifiers
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417121
Identifier Type: -
Identifier Source: org_study_id