Reconsolidation-Based Intervention for Traumatic Memories
NCT ID: NCT06143800
Last Updated: 2023-11-22
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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NOT_YET_RECRUITING
NA
390 participants
INTERVENTIONAL
2023-12-31
2025-09-30
Brief Summary
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* Is cognitive reappraisal based on memory reconsolidation effective for laboratory-created traumatic memories? Which of the two classical cognitive reassessment schemes is more effective?
* What is the neural mechanism by which the novel cognitive reappraisal based on memory reconsolidation alters traumatic memories?
* Can repeated use of the novel cognitive reappraisal based on memory reconsolidation alter the actual childhood traumatic memories of patients with major depression disorder? Can it reduce depressive symptoms? Are the effects long-lasting? Participants will be grouped to receive the intervention (retrieval + cognitive reappraisal, non-retrieval + cognitive reappraisal). The researchers will compare the differences in long-term memory tests and the improvement in depressive symptoms between the two groups to see the effects of the memory-based reconsolidation intervention.
Detailed Description
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Participants in the second trial are given the same treatment as in the first, but with brain imaging equipment to gain brain imaging data. The researchers will compare the brain functional characteristics of the four groups in the long-term memory test, in order to explore the neural mechanism of the effect of cognitive reappraisal on traumatic memory intervention based on memory reconsolidation mechanism.
Participants in the third trial are divided into two groups (retrieval + cognitive reappraisal, and non-retrieval + cognitive reappraisal) for an eight-week intervention. Finally, the researchers will compare the improvement in depressive symptoms between the two groups and retest physiological arousal and subjective assessments of traumatic memories one year later to see the long-term effects of the memory-based reconsolidation intervention.
Conditions
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Study Design
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RANDOMIZED
FACTORIAL
TREATMENT
SINGLE
Study Groups
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retrieval + self-focused cognitive reappraisal
Participants in this arm will first accept a memory reactivation to open the reconsolidation window, then accept the self-focused cognitive reappraisal intervention.
reactivation
During the retrieval phase, cues are presented to participants to reactivate their memories; participants in the non-retrieval group go directly to cognitive reappraisal phase.
cognitive reappraisal intervention
Subsequently, in the self-focused cognitive reappraisal group, participants will be instructed to use "disengagement" reappraisal to separate themselves from the picture situation and draw a subjective distance so as not to strongly feel the negative emotions brought by the picture. In the context-focused reappraisal group, participants will focus on the picture situation, reappraise the meaning of the picture situation, and assign positive meanings to it.
retrieval + context-focused cognitive reappraisal
Participants in this arm will first accept a memory reactivation to open the reconsolidation window, then accept the context-focused cognitive reappraisal.
reactivation
During the retrieval phase, cues are presented to participants to reactivate their memories; participants in the non-retrieval group go directly to cognitive reappraisal phase.
cognitive reappraisal intervention
Subsequently, in the self-focused cognitive reappraisal group, participants will be instructed to use "disengagement" reappraisal to separate themselves from the picture situation and draw a subjective distance so as not to strongly feel the negative emotions brought by the picture. In the context-focused reappraisal group, participants will focus on the picture situation, reappraise the meaning of the picture situation, and assign positive meanings to it.
non-retrieval + self-focused cognitive reappraisal
Participants in this arm will directly accept the self-focused cognitive reappraisal intervention without memory reactivation.
cognitive reappraisal intervention
Subsequently, in the self-focused cognitive reappraisal group, participants will be instructed to use "disengagement" reappraisal to separate themselves from the picture situation and draw a subjective distance so as not to strongly feel the negative emotions brought by the picture. In the context-focused reappraisal group, participants will focus on the picture situation, reappraise the meaning of the picture situation, and assign positive meanings to it.
non-retrieval + context-focused cognitive reappraisal
Participants in this arm will directly accept the context-focused cognitive reappraisal intervention without memory reactivation.
cognitive reappraisal intervention
Subsequently, in the self-focused cognitive reappraisal group, participants will be instructed to use "disengagement" reappraisal to separate themselves from the picture situation and draw a subjective distance so as not to strongly feel the negative emotions brought by the picture. In the context-focused reappraisal group, participants will focus on the picture situation, reappraise the meaning of the picture situation, and assign positive meanings to it.
Interventions
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reactivation
During the retrieval phase, cues are presented to participants to reactivate their memories; participants in the non-retrieval group go directly to cognitive reappraisal phase.
cognitive reappraisal intervention
Subsequently, in the self-focused cognitive reappraisal group, participants will be instructed to use "disengagement" reappraisal to separate themselves from the picture situation and draw a subjective distance so as not to strongly feel the negative emotions brought by the picture. In the context-focused reappraisal group, participants will focus on the picture situation, reappraise the meaning of the picture situation, and assign positive meanings to it.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Must have normal vision or corrected vision
Exclusion Criteria
* Be pregnant, breastfeeding or do not have menstruation
* Drink alcohol or smoke within 24 hours before the experiment
* Participated in similar experiments before.
* History of severe cardiovascular and cerebrovascular diseases, stroke and other neurological diseases, and history of digestive system diseases.
* Severe hearing and vision impairment.
* Have metal implants in the body, such as non-removable dentures, scaffolds, steel plates, joint metal replacements, etc.
* Have Claustrophobia
* Have acute or chronic disease or infection
18 Years
25 Years
ALL
Yes
Sponsors
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Science and Technology Innovation Commission of Shenzhen Municipality
OTHER
Shenzhen Kangning Hospital
OTHER
Responsible Party
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Jingchu Hu
Principal Investigator
Principal Investigators
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Jingchu Hu, Dr.
Role: PRINCIPAL_INVESTIGATOR
Shenzhen Kangning Hospital
Central Contacts
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Other Identifiers
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JCYJ20220530165003007
Identifier Type: -
Identifier Source: org_study_id