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Clinical Relevance of the Salvage Treatment for Colorectal Neuroendocrine Tumors

NCT ID: NCT06143605

Last Updated: 2023-11-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

527 participants

Study Classification

OBSERVATIONAL

Study Start Date

2013-01-30

Study Completion Date

2023-09-30

Brief Summary

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we evaluated all related clinical and pathologic data of rectal NET cases, including the resection margin status, NET grading, and lymphovascular invasion status. Finally, the present study was aimed at (1) determining the risk factors for LN and distant metastases in colorectal NETs (2) clarifying the clinical significance of the salvage treatment for colorectal neuroendocrine tumors following initial endoscopic resection with positive resection margin status and (3) compare different salvage treatment of this uncommon disease through conducting a large, multi-center cohort study.

Detailed Description

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Conditions

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Rectal Neoplasms Neuroendocrine Tumors

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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salvage treatment group

patients with salvage treatment after endoscopic resection were diagnosed as having positive resection margin status

salvage treatment

Intervention Type PROCEDURE

salvage radical surgery or endoscopic resection

without salvage treatment group

patients without salvage treatment after endoscopic resection were diagnosed as having positive resection margin status

No interventions assigned to this group

Interventions

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salvage treatment

salvage radical surgery or endoscopic resection

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* within the age range of 18 to 65 years, diagnosed with rectal neuroendocrine tumors. Furthermore, patients were required to have a palpable tumor as determined by digital rectal examination or accessible through proctoscopy, with the distal border situated within 12 cm from the anal verge.

Exclusion Criteria

* (1) muscularis propria invasion or NET grading = 3, (2)regional LN or distant organs metastasis at the time of diagnosis, (3) incomplete follow-up information, (4) the patient had multiple primary tumors, (5) patients with surgical excision or inappropriate methods such as forceps removal, and (6) the patient had a history of malignant tumors.
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Yanhong Deng

OTHER

Sponsor Role lead

Responsible Party

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Yanhong Deng

M.D.

Responsibility Role SPONSOR_INVESTIGATOR

Other Identifiers

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GIH-SYip33

Identifier Type: -

Identifier Source: org_study_id