Optimal Stimulation Parameters to Disrupt Epileptiform Activity

NCT ID: NCT06141668

Last Updated: 2024-11-20

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

30 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-06-13

Study Completion Date

2026-11-30

Brief Summary

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Open-loop electrical stimulation has been found to reduce spike activity and seizures, but determining the optimal parameters to achieve these effects requires a brute force trial-and-error approach that relies on subjective physician discretion. We will compare the performance of stimulation parameters identified in rodent models to the recommended parameters for neuromodulation used in clinical practice.

Detailed Description

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Conditions

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Refractory Epilepsy

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

SINGLE

Outcome Assessors

Interventions

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Neurostimulation

Electrical stimulation

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

\- Undergoing intracranial EEG investigation at Massachusetts General Hospital during presurgical epilepsy evaluation

Exclusion Criteria

\- Baseline spike ripple rate \< 0.5/min.
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Boston University

OTHER

Sponsor Role collaborator

National Institute of Neurological Disorders and Stroke (NINDS)

NIH

Sponsor Role collaborator

Massachusetts General Hospital

OTHER

Sponsor Role lead

Responsible Party

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Catherine Chu, MD

Associate Professor Neurology

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Catherine Chu, MD

Role: PRINCIPAL_INVESTIGATOR

Massachusetts General Hospital

Locations

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Massachusetts General Hospital

Boston, Massachusetts, United States

Site Status RECRUITING

Countries

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United States

Central Contacts

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Catherine Chu, MD

Role: CONTACT

617726-6540

Facility Contacts

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Catherine Chu

Role: primary

6177266540

Other Identifiers

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R01NS119483

Identifier Type: NIH

Identifier Source: secondary_id

View Link

2020P002398

Identifier Type: -

Identifier Source: org_study_id

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