A Global Study of Volrustomig (MEDI5752) for Participants With Unresected Locally Advanced Head and Neck Squamous Cell Carcinoma Following Definitive Concurrent Chemoradiotherapy
NCT ID: NCT06129864
Last Updated: 2025-11-26
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.
RECRUITING
PHASE3
1145 participants
INTERVENTIONAL
2023-12-14
2030-09-12
Brief Summary
Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.
Related Clinical Trials
Explore similar clinical trials based on study characteristics and research focus.
Study of Volrustomig in Women With High Risk Locally Advanced Cervical Cancer (eVOLVE-Cervical)
NCT06079671
Comparing Neoadjuvant Chemotherapy Combined With PD-1 Inhibitor Versus Neoadjuvant Chemotherapy in Locally Advanced Laryngeal and Hypopharyngeal Carcinoma
NCT06957938
Ph I Vorinostat in the Treatment of Advanced Staged Oropharyngeal Squamous Cell Carcinoma
NCT01064921
Response-Adaptive Treatment in Untreated Locoregional HPV-Negative Head and Neck Cancer
NCT07065630
Capecitabine and Vorinostat in Treating Patients With Recurrent and/or Metastatic Head and Neck Cancer
NCT01267240
Detailed Description
Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.
Conditions
See the medical conditions and disease areas that this research is targeting or investigating.
Study Design
Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.
RANDOMIZED
PARALLEL
TREATMENT
SINGLE
Study Groups
Review each arm or cohort in the study, along with the interventions and objectives associated with them.
Study Arm
Participants in this arm will receive volrustomig.
volrustomig
volrustomig
Observation Arm
Patients in this arm will undergo observation.
No interventions assigned to this group
Interventions
Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.
volrustomig
volrustomig
Other Intervention Names
Discover alternative or legacy names that may be used to describe the listed interventions across different sources.
Eligibility Criteria
Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.
Inclusion Criteria
* Confirmed unresected Stage III, Stage IVA or IVB according to the eighth edition of the American Joint Committee on Cancer (AJCC) staging manual (tumor, node, metastasis (TNM) staging system).
* Participants will have completed definitive concurrent chemoradiotherapy (cCRT) with curative intent prior to randomization.
* Participants with any of the following:
1. LA-HNSCC that was resected before definitive cCRT
2. LA-HNSCC that was treated and is recurrent at the time of screening
* Participants who have received radiotherapy (RT) alone as definitive local therapy for LA-HNSCC.
18 Years
130 Years
ALL
No
Sponsors
Meet the organizations funding or collaborating on the study and learn about their roles.
AstraZeneca
INDUSTRY
Responsible Party
Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.
Principal Investigators
Learn about the lead researchers overseeing the trial and their institutional affiliations.
Robert Haddad, MD
Role: STUDY_CHAIR
Dana Farber Cancer Institute Massachusetts, USA
Lisa Licitra, MD
Role: STUDY_CHAIR
Fondazione IRCCS Istituto Nazionale dei Tumori and University of Milan Milan, Italy
Locations
Explore where the study is taking place and check the recruitment status at each participating site.
Research Site
Birmingham, Alabama, United States
Research Site
Phoenix, Arizona, United States
Research Site
Prescott Valley, Arizona, United States
Research Site
Springdale, Arkansas, United States
Research Site
Fountain Valley, California, United States
Research Site
Los Angeles, California, United States
Research Site
Orange, California, United States
Research Site
San Francisco, California, United States
Research Site
Santa Rosa, California, United States
Research Site
Whittier, California, United States
Research Site
Aurora, Colorado, United States
Research Site
Colorado Springs, Colorado, United States
Research Site
Lone Tree, Colorado, United States
Research Site
Washington D.C., District of Columbia, United States
Research Site
Fort Myers, Florida, United States
Research Site
Gainesville, Florida, United States
Research Site
Miami, Florida, United States
Research Site
Palm Bay, Florida, United States
Research Site
West Palm Beach, Florida, United States
Research Site
Niles, Illinois, United States
Research Site
Des Moines, Iowa, United States
Research Site
Kansas City, Kansas, United States
Research Site
Louisville, Kentucky, United States
Research Site
Baton Rouge, Louisiana, United States
Research Site
Shreveport, Louisiana, United States
Research Site
Baltimore, Maryland, United States
Research Site
Bethesda, Maryland, United States
Research Site
Hyattsville, Maryland, United States
Research Site
Towson, Maryland, United States
Research Site
Upper Marlboro, Maryland, United States
Research Site
Boston, Massachusetts, United States
Research Site
Fairhaven, Massachusetts, United States
Research Site
Ann Arbor, Michigan, United States
Research Site
Ann Arbor, Michigan, United States
Research Site
Minneapolis, Minnesota, United States
Research Site
Columbia, Missouri, United States
Research Site
St Louis, Missouri, United States
Research Site
St Louis, Missouri, United States
Research Site
East Brunswick, New Jersey, United States
Research Site
Hackensack, New Jersey, United States
Research Site
New Brunswick, New Jersey, United States
Research Site
Albuquerque, New Mexico, United States
Research Site
New York, New York, United States
Research Site
New York, New York, United States
Research Site
Stony Brook, New York, United States
Research Site
Charlotte, North Carolina, United States
Research Site
Winston-Salem, North Carolina, United States
Research Site
Cleveland, Ohio, United States
Research Site
Portland, Oregon, United States
Research Site
Portland, Oregon, United States
Research Site
Philadelphia, Pennsylvania, United States
Research Site
Pittsburgh, Pennsylvania, United States
Research Site
York, Pennsylvania, United States
Research Site
Sioux Falls, South Dakota, United States
Research Site
Sioux Falls, South Dakota, United States
Research Site
Nashville, Tennessee, United States
Research Site
Austin, Texas, United States
Research Site
Dallas, Texas, United States
Research Site
Flower Mound, Texas, United States
Research Site
Houston, Texas, United States
Research Site
Odessa, Texas, United States
Research Site
Tyler, Texas, United States
Research Site
Salt Lake City, Utah, United States
Research Site
West Jordan, Utah, United States
Research Site
Fairfax, Virginia, United States
Research Site
Norfolk, Virginia, United States
Research Site
Richmond, Virginia, United States
Research Site
Spokane, Washington, United States
Research Site
Tacoma, Washington, United States
Research Site
Tacoma, Washington, United States
Research Site
Graz, , Austria
Research Site
Innsbruck, , Austria
Research Site
Linz, , Austria
Research Site
Salzburg, , Austria
Research Site
Vienna, , Austria
Research Site
Charleroi, , Belgium
Research Site
Edegem, , Belgium
Research Site
Jette, , Belgium
Research Site
La Louvière, , Belgium
Research Site
Namur, , Belgium
Research Site
Barretos, , Brazil
Research Site
Florianópolis, , Brazil
Research Site
Fortaleza, , Brazil
Research Site
Ijuí, , Brazil
Research Site
Ipatinga, , Brazil
Research Site
Londrina, , Brazil
Research Site
Natal, , Brazil
Research Site
Porto Alegre, , Brazil
Research Site
Ribeirão Preto, , Brazil
Research Site
Rio de Janeiro, , Brazil
Research Site
São Paulo, , Brazil
Research Site
São Paulo, , Brazil
Research Site
Teresina, , Brazil
Research Site
Calgary, Alberta, Canada
Research Site
Edmonton, Alberta, Canada
Research Site
Kelowna, British Columbia, Canada
Research Site
Kingston, Ontario, Canada
Research Site
London, Ontario, Canada
Research Site
Toronto, Ontario, Canada
Research Site
Montreal, Quebec, Canada
Research Site
Montreal, Quebec, Canada
Research Site
Montreal, Quebec, Canada
Research Site
Regina, , Canada
Research Site
Beijing, , China
Research Site
Beijing, , China
Research Site
Bengbu, , China
Research Site
Changchun, , China
Research Site
Changsha, , China
Research Site
Changsha, , China
Research Site
Chengdu, , China
Research Site
Chengdu, , China
Research Site
Chengdu, , China
Research Site
Chongqing, , China
Research Site
Chongqing, , China
Research Site
Dongwan, , China
Research Site
Fuzhou, , China
Research Site
Guangzhou, , China
Research Site
Guangzhou, , China
Research Site
Guangzhou, , China
Research Site
Guiyang, , China
Research Site
Hangzhou, , China
Research Site
Harbin, , China
Research Site
Hefei, , China
Research Site
Huizhou, , China
Research Site
Jinan, , China
Research Site
Kunming, , China
Research Site
Lanzhou, , China
Research Site
Nanchang, , China
Research Site
Nanning, , China
Research Site
Shanghai, , China
Research Site
Shenyang, , China
Research Site
Shijiazhuang, , China
Research Site
Tianjin, , China
Research Site
Tianjin, , China
Research Site
Ürümqi, , China
Research Site
Wuhan, , China
Research Site
Wuhan, , China
Research Site
Wuxi, , China
Research Site
Xi'an, , China
Research Site
Xiamen, , China
Research Site
Zhengzhou, , China
Research Site
Zhuhai, , China
Research Site
Avignon, , France
Research Site
Bordeaux, , France
Research Site
Le Mans, , France
Research Site
Lyon, , France
Research Site
Nice, , France
Research Site
Saint-Herblain, , France
Research Site
Toulouse, , France
Research Site
Villejuif, , France
Research Site
Berlin, , Germany
Research Site
Erlangen, , Germany
Research Site
Essen, , Germany
Research Site
Greifswald, , Germany
Research Site
Hamburg, , Germany
Research Site
Hanover, , Germany
Research Site
Leipzig, , Germany
Research Site
Lübeck, , Germany
Research Site
München, , Germany
Research Site
Rostock, , Germany
Research Site
Tübingen, , Germany
Research Site
Ulm, , Germany
Research Site
Würzburg, , Germany
Research Site
Budapest, , Hungary
Research Site
Budapest, , Hungary
Research Site
Budapest, , Hungary
Research Site
Budapest, , Hungary
Research Site
Győr, , Hungary
Research Site
Gyula, , Hungary
Research Site
Kecskemét, , Hungary
Research Site
Miskolc, , Hungary
Research Site
Nyíregyháza, , Hungary
Research Site
Pécs, , Hungary
Research Site
Szekszárd, , Hungary
Research Site
Bengaluru, , India
Research Site
Hyderabad, , India
Research Site
Jaipur, , India
Research Site
Kanpur, , India
Research Site
Kochi, , India
Research Site
Kolkata, , India
Research Site
Lucknow, , India
Research Site
Madurai, , India
Research Site
Mohali, , India
Research Site
New Delhi, , India
Research Site
Thiruvananthapuram, , India
Research Site
Vadodara, , India
Research Site
Varanasi, , India
Research Site
Aviano, , Italy
Research Site
Florence, , Italy
Research Site
Milan, , Italy
Research Site
Modena, , Italy
Research Site
Napoli, , Italy
Research Site
Padua, , Italy
Research Site
Pavia, , Italy
Research Site
Rozzano, , Italy
Research Site
Bunkyō City, , Japan
Research Site
Bunkyō City, , Japan
Research Site
Chiba, , Japan
Research Site
Chiba, , Japan
Research Site
Chūōku, , Japan
Research Site
Fukuoka, , Japan
Research Site
Hidaka-shi, , Japan
Research Site
Hiroshima, , Japan
Research Site
Kashiwa, , Japan
Research Site
Kobe, , Japan
Research Site
Kōtoku, , Japan
Research Site
Nagoya, , Japan
Research Site
Nagoya, , Japan
Research Site
Niigata, , Japan
Research Site
Okayama, , Japan
Research Site
Osaka, , Japan
Research Site
Osakasayama-shi, , Japan
Research Site
Sagamihara-shi, , Japan
Research Site
Sapporo, , Japan
Research Site
Sendai, , Japan
Research Site
Shiwa-gun, , Japan
Research Site
Sunto-gun, , Japan
Research Site
Yokohama, , Japan
Research Site
Yokohama, , Japan
Research Site
George Town, , Malaysia
Research Site
Johor Bahru, , Malaysia
Research Site
Kuala Lumpur, , Malaysia
Research Site
Kuala Lumpur, , Malaysia
Research Site
Kuala Selangor, , Malaysia
Research Site
Kuching, , Malaysia
Research Site
Cebu City, , Philippines
Research Site
General Santos, , Philippines
Research Site
Iloilo City, , Philippines
Research Site
Manila, , Philippines
Research Site
Pasig, , Philippines
Research Site
Quezon City, , Philippines
Research Site
West San Juan City, , Philippines
Research Site
Bialystok, , Poland
Research Site
Bielsko-Biala, , Poland
Research Site
Bydgoszcz, , Poland
Research Site
Gliwice, , Poland
Research Site
Olsztyn, , Poland
Research Site
Piotrkow Trybunalski, , Poland
Research Site
Siedlce, , Poland
Research Site
Tomaszów Mazowiecki, , Poland
Research Site
Warsaw, , Poland
Research Site
San Juan, , Puerto Rico
Research Site
Goyang-si, , South Korea
Research Site
Gyeonggi-do, , South Korea
Research Site
Incheon, , South Korea
Research Site
Seoul, , South Korea
Research Site
Seoul, , South Korea
Research Site
Seoul, , South Korea
Research Site
Suwon, , South Korea
Research Site
Badalona, , Spain
Research Site
Barcelona, , Spain
Research Site
Barcelona, , Spain
Research Site
Jaén, , Spain
Research Site
Madrid, , Spain
Research Site
Madrid, , Spain
Research Site
Madrid, , Spain
Research Site
Valencia, , Spain
Research Site
Valencia, , Spain
Research Site
Changhua, , Taiwan
Research Site
Kaohsiung City, , Taiwan
Research Site
Kaohsiung City, , Taiwan
Research Site
Taichung, , Taiwan
Research Site
Taichung, , Taiwan
Research Site
Taipei, , Taiwan
Research Site
Taipei, , Taiwan
Research Site
Taoyuan District, , Taiwan
Research Site
Bangkok, , Thailand
Research Site
Bangkok, , Thailand
Research Site
Bangkok, , Thailand
Research Site
Chaing Mai, , Thailand
Research Site
Hat Yai, , Thailand
Research Site
Khon Kaen, , Thailand
Research Site
Lampang, , Thailand
Research Site
Muang, , Thailand
Research Site
Mueang, , Thailand
Research Site
Ankara, , Turkey (Türkiye)
Research Site
Ankara, , Turkey (Türkiye)
Research Site
Antalya, , Turkey (Türkiye)
Research Site
Eskişehir, , Turkey (Türkiye)
Research Site
Istanbul, , Turkey (Türkiye)
Research Site
Karşıyaka, , Turkey (Türkiye)
Research Site
Yenimahalle, , Turkey (Türkiye)
Research Site
Aberdeen, , United Kingdom
Research Site
Cambridge, , United Kingdom
Research Site
Hampshire, , United Kingdom
Research Site
Leeds, , United Kingdom
Research Site
London, , United Kingdom
Research Site
London, , United Kingdom
Research Site
London, , United Kingdom
Research Site
Manchester, , United Kingdom
Research Site
Metropolitan Borough of Wirral, , United Kingdom
Research Site
Northwood, , United Kingdom
Research Site
Sutton, , United Kingdom
Research Site
Taunton, , United Kingdom
Research Site
Da Nang, , Vietnam
Research Site
Hanoi, , Vietnam
Research Site
Hà Nội, , Vietnam
Research Site
Ho Chi Minh City, , Vietnam
Research Site
Huế, , Vietnam
Research Site
Vinh, , Vietnam
Countries
Review the countries where the study has at least one active or historical site.
Central Contacts
Reach out to these primary contacts for questions about participation or study logistics.
Other Identifiers
Review additional registry numbers or institutional identifiers associated with this trial.
D798EC00001
Identifier Type: -
Identifier Source: org_study_id
More Related Trials
Additional clinical trials that may be relevant based on similarity analysis.