Musical Intervention on Stress Effects in Critically Ill Patients

NCT ID: NCT06120660

Last Updated: 2023-11-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

200 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-10-14

Study Completion Date

2025-12-31

Brief Summary

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Aim: To evaluate the effects of a musical intervention on serum cortisol, prolactin, interleukin-6 levels and physiological parameters in sedated patients undergoing invasive mechanical ventilation.

Detailed Description

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Design, Setting and Study Subjects: A randomized clinical trial will be conducted in the ICU of a spanish tertiary hospital. The study subjects will be adults, intubated, subjected to invasive mechanical ventilation, arterial catheter undergoing invasive mechanical ventilation, carrying an arterial catheter, with an adequate level of sedation and who do not present pain during the intervention.

Variables: The main variable will be total serum cortisol, prolactin, interleukin-6 levels. Secondary variables: secondary variables will be those used to measure physiological parameters to assess the patient's hemodynamic status of the patient in relation to the intervention.

Data collection: There will be 2 groups: intervention and control. The sample will be randomized as patients are admitted. First, they will be receiving the corresponding daily care. The first group of patients will receive the corresponding daily care. The patients in the intervention group will start the music therapy session through headphones, the patients in the control group will remain relaxed without any interruption during this time. All the variables will be collected before starting the study, during the study and at the end of the study.

Data analysis: A descriptive analysis of each variable will be performed. Subsequently, a bivariate analysis, previously checking the normality and homoscedasticity of the data.and homoscedasticity of the data. If statistically significant, post-hoc tests will be performed using Dunn's test.Dunn's test. Statistical significance will be accepted when p ≤ 0.05.

Conditions

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Critical Care Respiration, Artificial Sedation

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

SUPPORTIVE_CARE

Blinding Strategy

DOUBLE

Participants Caregivers

Study Groups

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Case Group

Music

Group Type EXPERIMENTAL

Music Therapy

Intervention Type OTHER

Music Therapy

Control Group

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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Music Therapy

Music Therapy

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Adults
* Admitted to the ICU for a minimum of 24 hours
* Intubated patients undergoing invasive mechanical ventilation
* Arterial catheter carriers / central venous catheter
* Sedation level: BIS: 40 - 60
* No pain at the time of and during the procedure, which will be measured by a score of 0 on ESCID scale
* Not having previously undergone any other musical intervention.

Exclusion Criteria

* Severe neurological disease or injury (CNS pathologies such as encephalitis, diffuse axonal injury, etc.)
* Severe psychiatric illness
* Suspected or confirmed drug or alcohol overdose/intoxication/abstinence
* Hearing impairment
* Skull lesions that preclude the use of headphones
* Patients with limitation of therapeutic effort or death expected within 24 hours
* Brain death diagnosis
* Failure to obtain informed consent from the legal representative within 72 hours of presentation
* Refusal of the responsible physician.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Sociedad Española de Enfermería Intensiva y Unidades Coronarias

UNKNOWN

Sponsor Role collaborator

University of Oviedo

OTHER

Sponsor Role lead

Responsible Party

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Alba Maestro Gonzalez

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Alba Maestro-González, Ph.D.

Role: PRINCIPAL_INVESTIGATOR

University of Oviedo

Locations

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Hospital Universitario Central de Asturias

Oviedo, Principality of Asturias, Spain

Site Status RECRUITING

Countries

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Spain

Central Contacts

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Alba Maestro-González, Ph.D.

Role: CONTACT

+34662186658

Facility Contacts

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Alba Maestro-González, Ph.D.

Role: primary

+34662186658

References

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Erdogan Z, Atik D. Complementary Health Approaches Used in the Intensive Care Unit. Holist Nurs Pract. 2017 Sep/Oct;31(5):325-342. doi: 10.1097/HNP.0000000000000227.

Reference Type BACKGROUND
PMID: 28786890 (View on PubMed)

Umbrello M, Sorrenti T, Mistraletti G, Formenti P, Chiumello D, Terzoni S. Music therapy reduces stress and anxiety in critically ill patients: a systematic review of randomized clinical trials. Minerva Anestesiol. 2019 Aug;85(8):886-898. doi: 10.23736/S0375-9393.19.13526-2. Epub 2019 Apr 3.

Reference Type BACKGROUND
PMID: 30947484 (View on PubMed)

Thaut MH. Music as therapy in early history. Prog Brain Res. 2015;217:143-58. doi: 10.1016/bs.pbr.2014.11.025. Epub 2015 Jan 31.

Reference Type BACKGROUND
PMID: 25725914 (View on PubMed)

Seyffert S, Moiz S, Coghlan M, Balozian P, Nasser J, Rached EA, Jamil Y, Naqvi K, Rawlings L, Perkins AJ, Gao S, Hunter JD 3rd, Khan S, Heiderscheit A, Chlan LL, Khan B. Decreasing delirium through music listening (DDM) in critically ill, mechanically ventilated older adults in the intensive care unit: a two-arm, parallel-group, randomized clinical trial. Trials. 2022 Jul 19;23(1):576. doi: 10.1186/s13063-022-06448-w.

Reference Type BACKGROUND
PMID: 35854358 (View on PubMed)

Kakar E, Billar RJ, van Rosmalen J, Klimek M, Takkenberg JJM, Jeekel J. Music intervention to relieve anxiety and pain in adults undergoing cardiac surgery: a systematic review and meta-analysis. Open Heart. 2021 Jan;8(1):e001474. doi: 10.1136/openhrt-2020-001474.

Reference Type BACKGROUND
PMID: 33495383 (View on PubMed)

Khan SH, Wang S, Harrawood A, Martinez S, Heiderscheit A, Chlan L, Perkins AJ, Tu W, Boustani M, Khan B. Decreasing Delirium through Music (DDM) in critically ill, mechanically ventilated patients in the intensive care unit: study protocol for a pilot randomized controlled trial. Trials. 2017 Nov 29;18(1):574. doi: 10.1186/s13063-017-2324-6.

Reference Type BACKGROUND
PMID: 29187230 (View on PubMed)

Khan SH, Kitsis M, Golovyan D, Wang S, Chlan LL, Boustani M, Khan BA. Effects of music intervention on inflammatory markers in critically ill and post-operative patients: A systematic review of the literature. Heart Lung. 2018 Sep-Oct;47(5):489-496. doi: 10.1016/j.hrtlng.2018.05.015. Epub 2018 Jul 9.

Reference Type BACKGROUND
PMID: 30001799 (View on PubMed)

Taets GGC, Jomar RT, Abreu AMM, Capella MAM. Effect of music therapy on stress in chemically dependent people: a quasi-experimental study. Rev Lat Am Enfermagem. 2019 Jan 17;27:e3115. doi: 10.1590/1518-8345.2456.3115.

Reference Type BACKGROUND
PMID: 30698217 (View on PubMed)

Other Identifiers

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Investiga SEEIUC 2023

Identifier Type: OTHER

Identifier Source: secondary_id

2022.537

Identifier Type: -

Identifier Source: org_study_id

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