Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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ACTIVE_NOT_RECRUITING
PHASE2
74 participants
INTERVENTIONAL
2023-10-05
2025-12-31
Brief Summary
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* How does rhythm-based training influence walking performance?
* How does brain activity change following rhythm-based training? Participants will perform walking to music and walking while singing, and will train on the use of these rhythms for 12 weeks. The investigators will compare the effects of training with music to training with singing.
Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
SINGLE
Study Groups
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Self cueing
Self-cueing training using singing, one hour sessions twice weekly for 12 weeks.
Self Cueing Training
Group classes led by a music therapist and using singing as a self-generated cue, with a focus on rhythm perception, rhythm generation and synchronization of movement to rhythms.
External cueing
External cueing using music, one hour sessions twice weekly for 12 weeks.
External Cueing Training
Group classes led by a music therapist and using music as an external cue, with a focus on rhythm perception, rhythm generation and synchronization of movement to rhythms.
Interventions
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Self Cueing Training
Group classes led by a music therapist and using singing as a self-generated cue, with a focus on rhythm perception, rhythm generation and synchronization of movement to rhythms.
External Cueing Training
Group classes led by a music therapist and using music as an external cue, with a focus on rhythm perception, rhythm generation and synchronization of movement to rhythms.
Eligibility Criteria
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Inclusion Criteria
2. diagnosis of idiopathic, typical Parkinson disease according to the UK Brain Bank Criteria
3. Hoehn \& Yahr stages 2-3 (mild to moderate disease severity)
4. evidence of walking impairment (score at least 1 on gait item of MDS\_UPDRS)
4\) stable on all Parkinson disease medications for at least 2 months prior to study entry 5) willing and able to provide informed consent 6) right-handed
Exclusion Criteria
2. a score of 2 or greater on item # 3 on the freezing of gait questionnaire
3. significant cognitive impairment
4. unstable medical or concomitant illnesses or psychiatric conditions which, in the opinion of the investigators, would preclude successful participation
5. cardiac problems that interfere with ability to safely participate
6. orthopedic problems in the lower extremities or spine that may limit walking
7. contraindications for magnetic resonance imaging
8. unable to walk for 10 continuous minutes independently
9. left-handed
10. uncontrolled tremor or dyskinesia
30 Years
ALL
No
Sponsors
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National Institutes of Health (NIH)
NIH
Washington University School of Medicine
OTHER
Responsible Party
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Gammon M Earhart
Professor
Locations
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Washington University School of Medicine
St Louis, Missouri, United States
Countries
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Other Identifiers
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202309088
Identifier Type: -
Identifier Source: org_study_id