Preemptive Oral Gabapentin and Tramadol on Postoperative Pain After Knee Arthroscopy

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

50 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-04-01

Study Completion Date

2023-09-01

Brief Summary

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The aim of this study to evaluate the effect of preemptive oral gabapentin versus tramadol on postoperative pain after knee arthroscopy under spinal anesthesia.

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Detailed Description

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Orthopedic surgeries are frequently associated with moderate-to-severe postoperative pain that can decrease mobility in the immediate postoperative period, interfere with postoperative rehabilitation, and delay hospital discharge. Pain may also become chronic.

Spinal anesthesia is the most popular anesthesia technique worldwide in orthopedic lower limb surgeries. However, its relatively short duration of action may limit the excellent postoperative analgesic effect. Thus, many adjuvants had been used to improve postoperative analgesia and decrease consumption of postoperative analgesics.

Gabapentin is a gamma aminobutyric acid analogue that is known as an anticonvulsant drug. This drug is tolerated well and has known effects on pain and anxiety.

Tramadol, a commonly used postoperative analgesic, is a synthetic centrally acting opioid analgesic. The various actions include inhibition of noradrenaline and serotonin reuptake, and also inhibition of M1 and M3 muscarinic receptors

Conditions

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Gabapentin Tramadol Postoperative Pain Knee Arthroscopy Spinal Anesthesia

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

DOUBLE

Participants Outcome Assessors

Study Groups

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Gabapentin

Patients will receive oral gabapentin 600 mg 1 hour before the surgery.

Group Type EXPERIMENTAL

Gabapentin

Intervention Type DRUG

Patients will receive oral gabapentin 600 mg 1 hour before the surgery.

Tramadol

Patients will receive oral tramadol 100 mg 1 hour before the surgery.

Group Type EXPERIMENTAL

Tramadol

Intervention Type DRUG

Patients will receive oral tramadol 100 mg 1 hour before the surgery.

Interventions

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Gabapentin

Patients will receive oral gabapentin 600 mg 1 hour before the surgery.

Intervention Type DRUG

Tramadol

Patients will receive oral tramadol 100 mg 1 hour before the surgery.

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Age 18-65 years old.
* Both sexes. American Society of Anesthesiologists (ASA) physical status I and II
* Undergoing knee arthroscopy procedures.
* under spinal anesthesia.

Exclusion Criteria

* Cardiac patients.
* Patients with known allergy to drug of study.
* Prolonged administration of NSAIDS or other analgesics due to chronic pain of any reason.
* Cirrhosis.

Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No