Changes in Resting Metabolic Rate Following Orthopedic Surgery
NCT ID: NCT06107959
Last Updated: 2025-07-11
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
100 participants
OBSERVATIONAL
2023-10-10
2026-12-31
Brief Summary
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Detailed Description
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This project will improve our understanding of magnitude and duration of RMR changes following orthopedic surgery, and the subsequent perioperative dietary suggestions that should be made to improve patient outcomes. Currently, postoperative dietary suggestions are not surgery nor patient specific. Determining how orthopedic surgery effects RMR will help to personalize perioperative treatment, rehabilitation, and recovery.
Better understanding the change in RMR following orthopedic surgery and implementing more accurate dietary modifications will help to ensure positive outcomes and control of infection following orthopedic surgery.
Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Male
50 male subjects undergoing orthopedic surgery.
Pre-surgical nutrition, hydration, RMR, and body composition assessments
Urine sample, InBody device platform, Metabolic cart with hood to collect RMR.
Post-surgical nutrition, hydration, RMR and body composition assessments
Same as pre-surgical tests at 1 week, 3 weeks, 6 weeks, and 12 weeks follow up time points.
Female
50 female subjects undergoing orthopedic surgery
Pre-surgical nutrition, hydration, RMR, and body composition assessments
Urine sample, InBody device platform, Metabolic cart with hood to collect RMR.
Post-surgical nutrition, hydration, RMR and body composition assessments
Same as pre-surgical tests at 1 week, 3 weeks, 6 weeks, and 12 weeks follow up time points.
Interventions
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Pre-surgical nutrition, hydration, RMR, and body composition assessments
Urine sample, InBody device platform, Metabolic cart with hood to collect RMR.
Post-surgical nutrition, hydration, RMR and body composition assessments
Same as pre-surgical tests at 1 week, 3 weeks, 6 weeks, and 12 weeks follow up time points.
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* \< 15 years old
15 Years
ALL
No
Sponsors
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University of Kansas Medical Center
OTHER
Responsible Party
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Lisa Vopat, MD
Principal Investigator
Locations
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The University of Kansas Medical Center
Kansas City, Kansas, United States
Countries
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Central Contacts
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Facility Contacts
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References
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Braga M, Baccari P, Scaccabarozzi S, Fiacco E, Radaelli G, Gallus G, DiPalo S, DiCarlo V, Cristallo M. Prognostic role of preoperative nutritional and immunological assessment in the surgical patient. JPEN J Parenter Enteral Nutr. 1988 Mar-Apr;12(2):138-42. doi: 10.1177/0148607188012002138.
Hu SS, Fontaine F, Kelly B, Bradford DS. Nutritional depletion in staged spinal reconstructive surgery. The effect of total parenteral nutrition. Spine (Phila Pa 1976). 1998 Jun 15;23(12):1401-5. doi: 10.1097/00007632-199806150-00019.
Lenke LG, Bridwell KH, Blanke K, Baldus C. Prospective analysis of nutritional status normalization after spinal reconstructive surgery. Spine (Phila Pa 1976). 1995 Jun 15;20(12):1359-67.
Ljungqvist O, Soop M, Hedstrom M. Why metabolism matters in elective orthopedic surgery: a review. Acta Orthop. 2007 Oct;78(5):610-5. doi: 10.1080/17453670710014293. No abstract available.
Malone DL, Genuit T, Tracy JK, Gannon C, Napolitano LM. Surgical site infections: reanalysis of risk factors. J Surg Res. 2002 Mar;103(1):89-95. doi: 10.1006/jsre.2001.6343.
McMulkin ML, Ferguson RL. Resting energy expenditure and respiratory quotient in adolescents following spinal fusion surgery. Spine (Phila Pa 1976). 2004 Aug 15;29(16):1831-5. doi: 10.1097/01.brs.0000134564.24874.10.
Other Identifiers
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STUDY00150689
Identifier Type: -
Identifier Source: org_study_id
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