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Osteocalcin Level in Gingival Clavicular Fluid During Canine Retraction in Periodontal Compromised Patients

NCT ID: NCT06102616

Last Updated: 2023-11-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

15 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-01-14

Study Completion Date

2023-08-23

Brief Summary

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Osteocalcin levels can be measured Gingival crevicular fluid (GCF). Changes in osteocalcin levels can provide important information about the status of bone metabolism and bone remodeling. The levels of this markers in GCF can provide information about the status of bone remodeling in the surrounding bone tissue in periodontal affected teeth.

Detailed Description

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Osteocalcin levels can be measured using a blood test or by analyzing the levels of osteocalcin in urine or saliva. Changes in osteocalcin levels can provide important information about the status of bone metabolism and bone remodeling. Osteocalcin has been found to be present in Gingival crevicular fluid (GCF), along with other bone metabolism markers such as alkaline phosphatase and tartrate-resistant acid phosphatase. The levels of these markers in GCF can provide information about the status of bone remodeling in the surrounding bone tissue. Orthodontic tooth movement is influenced by the remodelling ability of surrounding bone and soft tissue, such as PDL and gingiva. Bone remodelling occurs in coordination, requiring coupling of bone formation after resorption. Orthodontic force induces an aseptic inflammatory response, involving cytokines and chemokines. . Increased levels of osteocalcin in body fluids indicate abnormal bone turnover activity.

Conditions

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Periodontal Diseases

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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periodontal compromised orthodontic pateints

periodontal compromised adults female patients with sever dental crowding and seeking for orthodontic treatment

Group Type EXPERIMENTAL

measure Osteocalcin level

Intervention Type DIAGNOSTIC_TEST

in gingival crevicular fluid before and during orthodontic tooth movement

Interventions

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measure Osteocalcin level

in gingival crevicular fluid before and during orthodontic tooth movement

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* Adult female patients who were seeking for orthodontic treatment with controlled previous chronic periodontitis.
* Pocket depth of more than 5 mm before receiving non-surgical periodontal treatment or/and Pocket depth of less than 4 mm after periodontal therapy.
* Sever to very sever irregularity of mandibular anterior arch according to Little's irregularity index ranging from 7 to 10 mm with acceptable oral hygiene.
* all the permanent dentition excluding third molars should be present.
* No systemic disease or history of prolonged use of medication interfering with tooth movement as corticosteroids.

Exclusion Criteria

* Previous orthodontic treatment.
* Patients with aggressive periodontitis or Any smoking habits.
* Pregnant or lactating female patients were excluded.
Minimum Eligible Age

25 Years

Maximum Eligible Age

35 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Faculty of Dental Medicine for Girls

OTHER_GOV

Sponsor Role lead

Responsible Party

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Mohsena Ahmad

Lecturer of Orthodontics

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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faculty of dental medicine Azhar University

Cairo, , Egypt

Site Status

Countries

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Egypt

Other Identifiers

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12245

Identifier Type: -

Identifier Source: org_study_id