Safety Profile of Psilocybin for Cocaine Use Disorder

NCT ID: NCT06102434

Last Updated: 2025-12-22

Basic Information

• Recruitment Status: RECRUITING
• Clinical Phase: EARLY_PHASE1
• Total Enrollment: 10 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2026-02-01
• Study Completion Date: 2026-06-30

Brief Summary

The purpose of this study is to establish the safe administration of psilocybin in individuals with cocaine use disorder in terms of cardiovascular (e.g., heart rate) and subjective (e.g., mood) effects. The study's subject population consists of men and women between the ages of 21 and 55 from the Los Angeles area that meet criteria for cocaine use disorder and express an interest in ceasing cocaine use. 25 mg oral psilocybin will be administered to 10 individuals (separately) during a single laboratory visit. The laboratory visit will take place from 9 am until 3 pm within a comfortable, living room like environment. Within this study session room, participants will be accompanied by two clinicians. Participants will then consume the psilocybin capsule, and thereafter will be encouraged to lie down on a couch and introspect on the experience. At one-hour intervals following ingestion, participants will be tested briefly for changes in heart rate, blood pressure, and subjective effects. No blood draws, behavioral assessments, or neuroimaging is included in the study. Following the laboratory visit, investigators will check-in on participants remotely, after 48 hours, and 10, 50, and 90 days from the psilocybin session.

Conditions

Cocaine Use Disorder

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Psilocybin

25 mg psilocybin

Group Type: EXPERIMENTAL

Psilocybin

Intervention Type: DRUG

Five oral capsules containing 5 mg of psilocybin each

Interventions

Psilocybin

Five oral capsules containing 5 mg of psilocybin each

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

• Have a Body Mass Index from 18.5 - 34kg/m^2
• Score of at least 3 on the Severity of Dependence Scale
• Desire to cease cocaine use as indicated by a goal of complete cocaine abstinence on the Thoughts about Abstinence Questionnaire
• At least 1, but not more than 10 total lifetime use of a classical psychedelic (5-HT2a agonist)
• 0 use of a classical psychedelic in the last year

Exclusion Criteria

• History of serious adverse events in response to classical psychedelics including history of Hallucinogen Persisting Perceptive Disorder
• Abnormal electrocardiogram based on testing at study entrance
• A resting heart rate greater than 90 bpm
• Current hypertension (exceeding 140 systolic and 90 diastolic at resting)
• Current use of antidepressants or other serotonergic-affecting substances
• History of cardiac conditions
• History of hepatic or renal impairments
• History of stroke or Transient Ischemic Attack
• Epilepsy or history of seizures
• Immediate family or personal history of psychosis, bipolar disorder, or schizophrenia
• Anxiety or mood disorders determined by the Diagnostic and Statistical Manual of Mental Disorders 5 (DSM-V)
• Must not meet DSM-V criteria for any substance use disorders other than cocaine, caffeine, or nicotine
• Must not meet DSM-V criteria for borderline personality or dissociative disorders
• Current suicidal ideation or lifetime history of suicide attempts
• Arrest for a violent offense
• Any clinical condition, history of illness, or laboratory results that may place participants at greater risk as judged by the study physician
• Women will not be eligible if trying to get pregnant, pregnant, or lactating

• Minimum Eligible Age: 21 Years
• Maximum Eligible Age: 55 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

University of California, Los Angeles

OTHER

Sponsor Role: lead

Responsible Party

Conor Murray

Principal Investigator

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

University of California, Los Angeles

Los Angeles, California, United States

Site Status: RECRUITING

Countries

United States

Central Contacts

Conor H Murray, PhD

Role: CONTACT

Phone: 3107943383

Email: conormurray@mednet.ucla.edu

Facility Contacts

Ziva Cooper, PhD

Role: primary

Vince Acebo

Role: backup

Other Identifiers

21-002081

Identifier Type: -

Identifier Source: org_study_id