Peroperative Fluid Management in Major Gynecological Cancer Surgeries
NCT ID: NCT06101498
Last Updated: 2023-11-27
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
180 participants
INTERVENTIONAL
2023-01-01
2023-09-01
Brief Summary
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The main question\[s\] it aims to answer are:
Does fluid management applied with different hemodynamic monitoring methods affect the risk of postoperative AKI? In our clinic, three different fluid management strategies are applied depending on the anesthetist experience. Acute kidney injury will be evaluated according to the postoperative AKIN classification of conventional fluid therapy and targeted fluid therapy with noninvasive or minimally invasive monitoring.
Detailed Description
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Conditions
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Study Design
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NON_RANDOMIZED
PARALLEL
HEALTH_SERVICES_RESEARCH
SINGLE
Study Groups
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Conventional fluid therapy
Patients who received conventional fluid therapy
Akut kidnet injury(AKI)
postoperative 24 hours
Non invaziv goal directed therapy
Patients who received non invaziv goal directed therapy
Akut kidnet injury(AKI)
postoperative 24 hours
Minimal invaziv goal directed therapy
Patients who received minimal invaziv goal directed therapy
Akut kidnet injury(AKI)
postoperative 24 hours
Interventions
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Akut kidnet injury(AKI)
postoperative 24 hours
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* ASA II-III
* Those with normal renal function
Exclusion Criteria
* Patients with perioperative renal, ureter \& bladder invasion
* Patients in whom perioperative urine monitoring cannot be performed
* Patients undergoing HIPEC
* Patients with missing data
18 Years
FEMALE
Yes
Sponsors
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Bakirkoy Dr. Sadi Konuk Research and Training Hospital
OTHER_GOV
Responsible Party
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Duygu Akyol
Principal investigator
Principal Investigators
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Duygu Akyol
Role: PRINCIPAL_INVESTIGATOR
Başakşehir Çam & Sakura City Hospital
Locations
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Başakşehir Çam and Sakura City Hospital
Istanbul, Basaksehir, Turkey (Türkiye)
Countries
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References
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Yildiz GO, Hergunsel GO, Sertcakacilar G, Akyol D, Karakas S, Cukurova Z. Perioperative goal-directed fluid management using noninvasive hemodynamic monitoring in gynecologic oncology. Braz J Anesthesiol. 2022 May-Jun;72(3):322-330. doi: 10.1016/j.bjane.2021.12.012. Epub 2022 Feb 1.
Yu J, Che L, Zhu A, Xu L, Huang Y. Goal-Directed Intraoperative Fluid Therapy Benefits Patients Undergoing Major Gynecologic Oncology Surgery: A Controlled Before-and-After Study. Front Oncol. 2022 Apr 6;12:833273. doi: 10.3389/fonc.2022.833273. eCollection 2022.
Russo A, Aceto P, Grieco DL, Anzellotti GM, Perilli V, Costantini B, Romano B, Scambia G, Sollazzi L, Antonelli M. Goal-directed hemodynamic management in patients undergoing primary debulking gynaecological surgery: A matched-controlled precision medicine study. Gynecol Oncol. 2018 Nov;151(2):299-305. doi: 10.1016/j.ygyno.2018.08.034. Epub 2018 Sep 7.
Hasselgren E, Hertzberg D, Camderman T, Bjorne H, Salehi S. Perioperative fluid balance and major postoperative complications in surgery for advanced epithelial ovarian cancer. Gynecol Oncol. 2021 May;161(2):402-407. doi: 10.1016/j.ygyno.2021.02.034. Epub 2021 Mar 12.
McKenny M, Conroy P, Wong A, Farren M, Gleeson N, Walsh C, O'Malley C, Dowd N. A randomised prospective trial of intra-operative oesophageal Doppler-guided fluid administration in major gynaecological surgery. Anaesthesia. 2013 Dec;68(12):1224-31. doi: 10.1111/anae.12355. Epub 2013 Sep 30.
Other Identifiers
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2023.478
Identifier Type: -
Identifier Source: org_study_id