Study of [14C]CS0159 in China Healthy Subjects

NCT ID: NCT06098027

Last Updated: 2023-11-21

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1

Total Enrollment

6 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-10-23

Study Completion Date

2023-11-02

Brief Summary

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Study of \[14C\]CS0159 in China Healthy Subjects.

Detailed Description

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A phase I study to quantify the total mass balance in healthy subjects after a single dose of \[14C\]CS0159.

Conditions

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Primary Biliary Cholangitis

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

OTHER

Blinding Strategy

NONE

Study Groups

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[14C]CS0159

Single oral dose of 4mg \[14C\]CS0159

Group Type EXPERIMENTAL

[14C]CS0159

Intervention Type DRUG

Single oral administration of 4mg \[14C\]CS0159

Interventions

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[14C]CS0159

Single oral administration of 4mg \[14C\]CS0159

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

1. Healthy male subjects between the ages of 18 and 45 years (inclusive).
2. Subjects should not weigh less than 50 kg, BMI between 19\~26 kg/㎡.
3. No sperm donation or fertility plan during the study and within 12 months after the end of the study.
4. Understand the purpose and requirements of trial, subjects who have voluntarily participated in the study and signed the ICF, completion of tests as required.

Exclusion Criteria

1. With abnormal and clinically significant comprehensive physical examinations, vital signs,laboratory examinations, 12-ECG, chest X-ray, and abdominal ultrasound.
2. 12-ECG QT(QTcF)\>450ms.
3. The history of drug allergy.
4. Patients with malabsorption and gastrointestinal disorders or history of Vomiting, diarrhoea in the week prior to the screening period.
5. Patients with difficulty swallowing or interfere with drug absorption.
6. HBs Ag or E antigen, TPAb, or HIV-Ag/Ab positive person.
7. Have taken any clinical trial medication or participated in any other clinical trial within 3 months prior to the screening period.
8. Habitual constipation or diarrhoea.
9. Heavy smokers addicts
10. Heavy drinker addicts.
11. Has drug abuse history or positive drug abuse test results.
12. Heavy caffeine addicts.
13. Special dietary requirements.
14. Poor adherence or any other conditions judged by the investigator as not suitable for the study.
Minimum Eligible Age

18 Years

Maximum Eligible Age

45 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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Cascade Pharmaceuticals, Inc

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Deng Rong

Role: STUDY_DIRECTOR

Cascade Pharmaceuticals, Inc

Locations

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The First Affiliated Hospital of Soochow University

Suzhou, Jiangsu, China

Site Status

Countries

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China

Other Identifiers

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CS0159-001B

Identifier Type: -

Identifier Source: org_study_id