Tobacco and Alcohol Influence on Oncogenic Drivers and Somatic Evolution in the Oral Mucosa
NCT ID: NCT06094829
Last Updated: 2024-06-26
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
100 participants
OBSERVATIONAL
2023-11-23
2024-03-08
Brief Summary
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This is a multi-centric, descriptive, non-interventional cohort in healthy adult subjects. The aim of the study is to detect the presence of OSCC driver gene mutations in healthy subjects' oral mucosa, quantify whether they provide cells with a selective advantage, and study the impact of tobacco and alcohol consumption on the mutational load. This study will not allow to identify potential malignant cells, and will be usable for diagnostic purposes.
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Detailed Description
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Conditions
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Study Design
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OTHER
CROSS_SECTIONAL
Study Groups
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Smokers
Healthy subjects having smoked 100 cigarettes or more during their life.
Oral cytobrush
Oral epithelial cells will be collected during routine odontology appointments, upon documented non-opposition, via minimally invasive cytobrush sampling of the inner cheek
Non-smokers
Healthy subjects having smoked less than 100 cigarettes during their life.
Oral cytobrush
Oral epithelial cells will be collected during routine odontology appointments, upon documented non-opposition, via minimally invasive cytobrush sampling of the inner cheek
Interventions
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Oral cytobrush
Oral epithelial cells will be collected during routine odontology appointments, upon documented non-opposition, via minimally invasive cytobrush sampling of the inner cheek
Eligibility Criteria
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Inclusion Criteria
* Subject coming to odontology practice for routine visit.
* Subject having accepted to participate to the research by oral non-opposition
* Subject having given additional written consent for genetic studies.
* Smoking group criterion: subjects having smoked 100+ cigarettes/joints during their life.
Exclusion Criteria
* Treatment with anticoagulants or platelet aggregation inhibitors.
* Bilateral lesions of the inner cheek preventing painless biological sample collection.
* Subject under under guardians or curators
* Pregnancy or breastfeeding
* Cannabis usage
18 Years
ALL
Yes
Sponsors
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Hospices Civils de Lyon
OTHER
Responsible Party
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Locations
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Cabinet Libéral Picquendar
Bougival, , France
Cabinet Libéral Balayre
Chassieu, , France
Cabinet Libéral Debeauvais
Châtillon-Coligny, , France
Cabinet Libéral Finet
Fontaine-lès-Dijon, , France
Cabinet Libéral Jaeggy
Haguenau, , France
Unité de chirurgie et médecine orales (UCMO) - HCL - Hôpital Edouard Herriot- Pavillon R
Lyon, , France
Centre de Consultations et de Traitements Dentaires HCL
Lyon, , France
Cabinet Libéral Grammatica
Lyon, , France
Cabinet Libéral Cougot
Meudon, , France
Cabinet Libéral Calvo
Quint-Fonsegrives, , France
Cabinet Libéral Glomet
Saumur, , France
Cabinet Libéral Dutour
Theix, , France
Cabinet Libéral Masri
Vandœuvre-lès-Nancy, , France
Cabinet Libéral Bondil
Villefranche-sur-Saône, , France
Cabinet Libéral Janisset-Masse
Villiers-sur-Marne, , France
Countries
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Other Identifiers
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69HCL22_0749
Identifier Type: -
Identifier Source: org_study_id
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