Long Term Effects of Heat and Moisture Exchangers (HMEs)

NCT ID: NCT06084611

Last Updated: 2025-10-03

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

80 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-03-26

Study Completion Date

2025-09-30

Brief Summary

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Assessment of long term effect of Provox Life HME use on pulmonary symptoms in laryngectomized patients.

Detailed Description

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Conditions

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Laryngectomy; Status

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Randomized Controlled Trial
Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Provox Life HME

Use of Provox Life HMEs and attachment

Group Type EXPERIMENTAL

Provox Life

Intervention Type DEVICE

Compliant use of Provox Life HMEs

Control - No HME

Control group is current standard of Care in Brazil, which is not using an HME

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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Provox Life

Compliant use of Provox Life HMEs

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Total laryngectomy, irrespective of pharynx reconstruction method
* 18 years or older
* Longer than 3 months after total laryngectomy
* Longer than 6 weeks after postoperative radiotherapy

Exclusion Criteria

* Current use of HMEs (within last 3 months)
* Medical problems prohibiting the use of HME
* Active recurrent or metastatic disease (medical deterioration)
* Recent pulmonary infections/unstable pulmonary condition
* Insufficient physical, cognitive, or mental ability required to attach, remove or operate the devices themselves
* Low tidal volumes
* Unable to understand the Participant Information and/or unable to give Informed Consent
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Instituto de Cancer Dr Arnaldo

UNKNOWN

Sponsor Role collaborator

Atos Medical AB

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Instituto de Cancer Dr. Arnaldo

São Paulo, , Brazil

Site Status

Countries

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Brazil

Other Identifiers

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PL_Brazil

Identifier Type: -

Identifier Source: org_study_id

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