Leveraging Psychological Autopsies to Accelerate Research Into Stimulant Overdose Mortality

NCT ID: NCT06076564

Last Updated: 2024-11-27

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 176 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2022-06-06
• Study Completion Date: 2024-02-12

Brief Summary

In the LASSO study, the investigators will identify 100 stimulant overdose decedents (divided among stimulant-only, and stimulant with fentanyl), conduct informant interviews (including scales and qualitative data), and gather data from the postmortem investigation (e.g., vital records, toxicology, autopsy, case narrative, death scene photographs) and medical record abstraction. Subsequently, study staff will conduct qualitative interviews with 40-60 living people who use stimulants (aiming for half methamphetamine, half cocaine) to explore elements of resilience and risk reduction strategies. This study aims to contribute to the eventual design of interventions to reduce stimulant overdose mortality.

Detailed Description

Death from acute stimulant toxicity ("overdose") is rapidly rising across the United States. While there are decades of research and program development undergirding opioid overdose prevention, there is minimal understanding of the nature of stimulant overdose mortality. Psychological autopsies have been shown to be immensely valuable in understanding opioid overdose deaths, identifying many of the key elements of overdose that still drive overdose prevention efforts today, and the investigators propose to leverage that mechanism to accelerate our understanding of and response to stimulant overdose mortality, as well as the role of fentanyl in fatal stimulant overdose.

The investigators will identify 100 stimulant overdose decedents (divided among stimulant-only, and stimulant with fentanyl), conduct informant interviews (including scales and qualitative data), and gather data from the postmortem investigation (e.g., vital records, toxicology, autopsy, case narrative, death scene photographs) and medical record abstraction. Subsequently, the study team will conduct qualitative interviews with 40-60 living people who use stimulants (aiming for half methamphetamine, half cocaine) to explore elements of resilience and risk reduction strategies. This study aims to contribute to the eventual design of interventions to reduce stimulant overdose mortality.

Conditions

Stimulant Overdose; Overdose Accidental; Overdose Cocaine; Overdose Methamphetamine

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: RETROSPECTIVE

Study Groups

Informants

Informants are individuals who knew someone who had a fatal stimulant overdose. Once a decedent is selected, their records will be reviewed to familiarize the interviewer with the situation of their death. Informants will be identified using contacts that the OCME used during their investigation, death records from the state, or emergency contacts from medical records, followed by recommendations from any of those contacts.

No interventions assigned to this group

Living Persons who use Stimulants

To identify resilience factors and risk reduction strategies among living persons who use stimulants, study staff will conduct interviews with up to 60 adults who use either cocaine or methamphetamine.

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

All informants must be at least 18 years of age and have knowledge of the decedent and that the decedent used substances.

1. are aware the decedent used substances in the past year prior the to date of death AND

2. have been in contact with the decedent in the past year prior to the date of death by phone, email, or in person

OR

1. are aware the decedent used substances in the past 30 days prior to the date of death and

2. have been in contact with the decedent in person in the past year prior to the date of death.

Living persons who use stimulants:

1. ≥18 years of age,

2. Used cocaine or methamphetamine for ≥5 years,

3. Used cocaine or methamphetamine for ≥10 out of the past 30 days, AND

4. Matched to a decedent on age, race/ethnicity, gender, and neighborhood distribution of decedents of the methamphetamine/no opioid and cocaine/no opioid decedents.

Exclusion:

Informants:

Exclusion Criteria

Living persons who use stimulants:

1. Used both cocaine and methamphetamine ≥5 of past 30 days,

2. Intentionally use illicit opioids, OR

3. Unable to communicate in English or Spanish.

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

San Francisco Department of Public Health

OTHER_GOV

Sponsor Role: lead

Responsible Party

Phillip Coffin, MD, MIA

Director, Center on Substance Use and Health

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

San Francisco Department of Public Health

San Francisco, California, United States

Countries

United States

Other Identifiers

R01CE003364

Identifier Type: NIH

Identifier Source: org_study_id

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