Neutrophil-lymphocyte and Platelet-lymphocyte Ratios and Their Relations to Vascular Comlications and Glycemic Control in Patients With Type 2 Diabetes Attending The Diabetes Center of Assiut University Hospitals

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Total Enrollment

106 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-12-31

Study Completion Date

2027-12-31

Brief Summary

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Evaluate PLR and NLR and their assiotation to vascular complications and glycemic control in type 2 DM

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Detailed Description

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Vascular complications of DM result from various disorders including metabolic, cellular, and blood disturbances. Excessive production of pro-inflammatory adipokines from adipose tissue, resulting in low-grade chronic inflammation, causing insulin resistance (IR) and type 2 DM \[3\]. Hematological changes affecting the red blood cells (RBCs), white blood cells (WBCs), platelet function, and the coagulation factors are detected to be associated with DM . It is important to add that, high WBC count, one of the chief components of inflammatory process, sharing to atheroscle-rosis development and cardiovascular diseases (CVD) . Lately, the neutrophil-to-lymphocyte (N/L) and the platelet-to-lymphocyte (P/L) ratios, were offered as markers of inflammation in cardiac diseases, neoplasms and diabetes-related complications . Moreover, high leucocyte counts have been used as diagnostic and prognostic markers in vascular complication of diabetes

Conditions

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Vascular Complication, Diabetic

Study Design

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Observational Model Type

COHORT

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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1

Type 2 diabetes mellitus (T2DM) patients with good glycemic control and have HBA1C \<7and ages ranging from ≥18 old.

Echocardiogram

Intervention Type RADIATION

Evaluate PLR and NLR and their assiotation to vascular complications and glycemic control in type 2 DM

2

Type 2 diabetes mellitus (T2DM) patients with poor glycemic control and have HBA1C ≥7 and ages rang from ≥ 18 years old

Echocardiogram

Intervention Type RADIATION

Evaluate PLR and NLR and their assiotation to vascular complications and glycemic control in type 2 DM

Interventions

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Echocardiogram

Evaluate PLR and NLR and their assiotation to vascular complications and glycemic control in type 2 DM

Intervention Type RADIATION

Other Intervention Names

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ALB / cr ratio Fundus examination ECG Doppler on lower limbs Nerve conduction Echo

Eligibility Criteria

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Inclusion Criteria

* Type 2 diabetes mellitus (T2DM) patients with good glycemic control and have HBA1C \<7and ages ranging from ≥18 old. And poor glycemic control and have HBA1C ≥7 and ages rang from ≥ 18 years old

Exclusion Criteria

* Patients with, type 1 diabetes mellitus

1. Idiopathic thrombocytopenic purpura,
2. liver cell failure
3. Myeloproliferative neoplasm
4. patients on anticoagulant drugs , anti platelet drugs or on steroids were excluded from the study

Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No