Achieving Understanding of the Natural History of Sickle Cell Trait (AUNT)

NCT ID: NCT06071377

Last Updated: 2025-11-06

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

1000 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-04-01

Study Completion Date

2027-02-28

Brief Summary

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The main purpose of this study is to create a longitudinal cohort of those with Sickle Cell Trait (SCT) to better understand the hematologic phenotype for those that carry HbS, assess for differences in those with varying quantities of HbS and assess for potential clinical complications of SCT.

Detailed Description

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Conditions

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Sickle Cell Trait

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Individuals with sickle cell trait

Biologic Specimen Collection

Intervention Type OTHER

Participants will have blood and urine collected at Baseline

Interventions

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Biologic Specimen Collection

Participants will have blood and urine collected at Baseline

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

1. Are willing to voluntarily participate and sign the study consent
2. Know/suspect they have SCT and are willing to get tested to confirm/learn about their SCT status
3. Adults ages 18 and older

Exclusion Criteria

1. Unwilling to sign consent
2. Known end-stage renal disease or dialysis
3. Known SCD (including sickle cell-beta thalassemia)
4. People who do not have SCT
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Beam Therapeutics Inc.

INDUSTRY

Sponsor Role collaborator

National Alliance for Sickle Cell Centers

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Julie Kanter, MD

Role: PRINCIPAL_INVESTIGATOR

National Alliance for Sickle Cell Centers

Locations

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University of Alabama

Birmingham, Alabama, United States

Site Status RECRUITING

Loma Linda University Health Care

Loma Linda, California, United States

Site Status RECRUITING

Nemours Children's Hospital

Wilmington, Delaware, United States

Site Status RECRUITING

Indiana University

Indianapolis, Indiana, United States

Site Status RECRUITING

Functional Fluidics

Detroit, Michigan, United States

Site Status RECRUITING

University of North Carolina

Chapel Hill, North Carolina, United States

Site Status RECRUITING

Duke University

Durham, North Carolina, United States

Site Status RECRUITING

East Carolina University

Greenville, North Carolina, United States

Site Status RECRUITING

Nationwide Children's Hospital

Columbus, Ohio, United States

Site Status RECRUITING

UT Health Houston

Houston, Texas, United States

Site Status RECRUITING

Countries

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United States

Central Contacts

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Julie Kanter, MD

Role: CONTACT

Phone: (202) 596-1548

Email: [email protected]

Facility Contacts

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Marteesa William Oliver

Role: primary

Monica Pizana

Role: primary

Nicole Wittmeyer

Role: primary

Claire Kendrick

Role: primary

Jennell White, PhD

Role: primary

Ifeoma Iwuagwu

Role: backup

David Wichlan

Role: primary

Morgan Low

Role: primary

Sean Segre

Role: primary

Tiffany Rosetti

Role: primary

Amanda Gregg

Role: primary

Other Identifiers

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AUNT

Identifier Type: -

Identifier Source: org_study_id