LDCT Chest In Assessment Of Apparently Healthy Smokers

NCT ID: NCT06070922

Last Updated: 2023-10-06

Basic Information

• Recruitment Status: UNKNOWN
• Total Enrollment: 100 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2023-10-20
• Study Completion Date: 2024-12-20

Brief Summary

To evaluate the effectiveness of LDCT screening in detecting early-stage lung cancers among smokers who do not have symptoms of lung disease.

Detailed Description

Tobacco smoking is the leading preventable cause of death worldwide .Chronic Obstructive Pulmonary Disease (COPD), lung cancer, and cardiovascular disease will be responsible for the majority of deaths in the developed world in the coming decades .

COPD is characterised by chronic airflow limitation caused by a combination of small airway inflammation and parenchymal destruction (emphysema) . Since computed tomography (CT) has been validated as a non-invasive technique capable of identifying areas of lung parenchyma with emphysema , several studies have identified a subgroup of apparently healthy smokers who have emphysema but no airway obstruction Furthermore, this subgroup has the highest risk of developing lung cancer among smokers .It has been proposed that systemic inflammation may play an important pathogenic role in carcinogenesis . We will conducted this cross sectional study between. current and former smokers without airway obstruction participating in a lung cancer screening study: a study group of smokers with emphysema on the CT, and a control group of smokers without emphysema.

Conditions

Smoking

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Eligibility Criteria

Inclusion Criteria

• Participants have at least 45years old had smoked 10 pack-years or more

Exclusion Criteria

• Age: less than 45 years. Non smoker Evidence of airway obstruction by Pulmonery Function Test

• Minimum Eligible Age: 45 Years
• Maximum Eligible Age: 75 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Assiut University

OTHER

Sponsor Role: lead

Responsible Party

Hend Mohamed Sayed Mohamed

Lecture of chest diseases

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Mustafa sayed, lecture

Role: STUDY_CHAIR

Assiut University

Central Contacts

Hend saleh, lecture

Role: CONTACT

hend.m.saleh@gmail.com

01098988712

samiaa mohamed, professor

Role: CONTACT

Samiaa2023@yahoo.com

01006769597

References

Koyama H, Ohno Y, Yamazaki Y, Matsumoto K, Onishi Y, Takenaka D, Yoshikawa T, Nishio M, Matsumoto S, Murase K, Nishimura Y, Sugimura K. Reduced-dose chest CT with 3D automatic exposure control vs. standard chest CT: quantitative assessment of emphysematous changes in smokers' lung parenchyma. Eur J Radiol. 2012 Jun;81(6):1330-4. doi: 10.1016/j.ejrad.2011.03.037. Epub 2011 Jun 24.

Reference Type: BACKGROUND

PMID: 21703788 (View on PubMed)

Bonney A, Malouf R, Marchal C, Manners D, Fong KM, Marshall HM, Irving LB, Manser R. Impact of low-dose computed tomography (LDCT) screening on lung cancer-related mortality. Cochrane Database Syst Rev. 2022 Aug 3;8(8):CD013829. doi: 10.1002/14651858.CD013829.pub2.

Reference Type: BACKGROUND

PMID: 35921047 (View on PubMed)

Other Identifiers

Low Dose CT & healthy smoker

Identifier Type: -

Identifier Source: org_study_id