Incretin Effect in Patients With Psoriasis and Controls

NCT ID: NCT06064084

Last Updated: 2023-10-03

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

24 participants

Study Classification

OBSERVATIONAL

Study Start Date

2011-09-11

Study Completion Date

2015-09-11

Brief Summary

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To investigate the incretin effect and postprandial incretin responses in plasma in patients with psoriasis

Detailed Description

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Conditions

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Psoriasis Vulgaris

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

OTHER

Study Groups

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Psoriasis

Oral glucose tolerance test

Intervention Type DIAGNOSTIC_TEST

Oral glucose tolerance test 50g

Intravenous isoglycaemic glucose clamp

Intervention Type OTHER

Intravenous isoglycaemic glucose clamp

Liquid Mixed meal test

Intervention Type OTHER

Liquid Mixed meal test 520 kcal

Control

Age, Sex and BMI matched

Oral glucose tolerance test

Intervention Type DIAGNOSTIC_TEST

Oral glucose tolerance test 50g

Intravenous isoglycaemic glucose clamp

Intervention Type OTHER

Intravenous isoglycaemic glucose clamp

Liquid Mixed meal test

Intervention Type OTHER

Liquid Mixed meal test 520 kcal

Interventions

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Oral glucose tolerance test

Oral glucose tolerance test 50g

Intervention Type DIAGNOSTIC_TEST

Intravenous isoglycaemic glucose clamp

Intravenous isoglycaemic glucose clamp

Intervention Type OTHER

Liquid Mixed meal test

Liquid Mixed meal test 520 kcal

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

no diabetes BMI \< 27 kg/m\^2 normal Glucose tolerance test at screening normal fasting plasma glucose no islet auto antibodies no hormonel contraception informed consent psoriasis vulgaris (PASI\>8) (case not controls)

Exclusion Criteria

other chronic inflammtory skin disease other chronic inflammatory disease pregnancy psychiatric illness
Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University Hospital, Gentofte, Copenhagen

OTHER

Sponsor Role lead

Responsible Party

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Filip Krag Knop

Professor, MD

Responsibility Role PRINCIPAL_INVESTIGATOR

References

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Lauritsen JV, Bergmann N, Junker AE, Gyldenlove M, Skov L, Gluud LL, Hartmann B, Holst JJ, Vilsboll T, Knop FK. Oral glucose has little or no effect on appetite and satiety sensations despite a significant gastrointestinal response. Eur J Endocrinol. 2023 Dec 6;189(6):619-626. doi: 10.1093/ejendo/lvad161.

Reference Type DERIVED
PMID: 38035766 (View on PubMed)

Other Identifiers

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11031999

Identifier Type: -

Identifier Source: org_study_id

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