Virtual Interactive 3D Modelling to Improve Outcomes in Robotic-Assisted Partial Nephrectomy

NCT ID: NCT06056505

Last Updated: 2024-12-09

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

370 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-10-24

Study Completion Date

2026-09-30

Brief Summary

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The primary objective is to determine if 3D modelling shortens total console operation time as a surrogate endpoint for clinical outcomes like perioperative complications and morbidity in robotic-assisted partial nephrectomy.

Detailed Description

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3DPN is a prospective, multicentre, randomised, controlled, two-armed, open trial to compare the 3D modelling with the 2D modelling in robotic-assisted partial nephrectomy. According to the randomisation the 3D or 2D modelling is used for patient information (before intervention) and for partial nephrectomy. A six-month follow-up visit is provided.

Conditions

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Kidney Tumor

Keywords

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DaVinci Surgical System robotic-assisted partial nephrectomy Kidney tumours

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Parallel Assignment randomization to 3D or 2D modelling
Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Partial kidney nephrectomy with aid of 3D model

The patient information (before intervention) and the surgery (partial nephrectomy) will be performed with the aid of 3D modelling of the kidney.

Group Type EXPERIMENTAL

partial kidney nephrectomy

Intervention Type PROCEDURE

surgery for partial nephrectomy

DaVinci Robot

Intervention Type DEVICE

device to perform the surgery for partial nephrectomy (not the intervention of interest)

Innersight 3D software

Intervention Type DEVICE

investigational product to generate the 3D model

Partial kidney nephrectomy with aid of 2D model

The patient information (before intervention) and the surgery (partial nephrectomy) will be performed with the aid of 2D modelling of the kidney.

Group Type ACTIVE_COMPARATOR

partial kidney nephrectomy

Intervention Type PROCEDURE

surgery for partial nephrectomy

DaVinci Robot

Intervention Type DEVICE

device to perform the surgery for partial nephrectomy (not the intervention of interest)

Interventions

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partial kidney nephrectomy

surgery for partial nephrectomy

Intervention Type PROCEDURE

DaVinci Robot

device to perform the surgery for partial nephrectomy (not the intervention of interest)

Intervention Type DEVICE

Innersight 3D software

investigational product to generate the 3D model

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Patients with kidney tumours ≤ 7cm and planned robotic-assisted partial nephrectomy with the DaVinci Surgical System
* CT scan with contrast medium available
* Age ≥ 18 years
* Written informed consent

Exclusion Criteria

* History of surgery on affected kidney (e.g., partial nephrectomy, pyeloplasty, kidney cyst deroofing, percutaneous nephrolitholapaxy, radiofrequency ablation)
* Horseshoe kidney
* Previous malignancy with ongoing or planned nephrotoxic chemotherapy
* Patient is immunosuppressed (e.g., organ transplantation, leukaemia)
* Tumor thrombus in Vena renalis or Vena cava inferior
* Existing renal insufficiency GFR \< 15 ml/min/1.73m2
* Severe cognitive impairment
* Pregnancy or lactation or women with desire for children
* Patients under legal supervision or guardianship
* Unable to give informed consent or suspected lack of compliance
* Patients who refuse to data collection and storage for the main study
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of Leipzig

OTHER

Sponsor Role lead

Responsible Party

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Jens-Uwe Stolzenburg

Prof. Dr.

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Jens-Uwe Stolzenburg, Prof.

Role: STUDY_CHAIR

Leipzig University, Department of Urology

Locations

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Universitätsklinikum Carl Gustav Carus Dresden, Klinik und Poliklinik für Urologie

Dresden, Saxony, Germany

Site Status RECRUITING

Leipzig University, Department of Urology

Leipzig, Saxony, Germany

Site Status RECRUITING

Sana Klinikum Borna, Klinik für Urologie

Borna, , Germany

Site Status NOT_YET_RECRUITING

St. Antonius-Hospital Gronau, Klinik für Urologie, Kinderurologie und Urologische Onkologie

Gronau, , Germany

Site Status RECRUITING

Universitätsklinikum des Saarlandes - Homburg/Saar, Klinik für Urologie und Kinderurologie

Homburg, , Germany

Site Status RECRUITING

Universitätsklinikum Magdeburg, Klinik für Urologie, Uroonkologie, robotergestützte und fokale Therapie

Magdeburg, , Germany

Site Status NOT_YET_RECRUITING

Universitätsmedizin Mainz, Klinik und Poliklinik für Urologie und Kinderurologie

Mainz, , Germany

Site Status NOT_YET_RECRUITING

Universitätsmedizin Mannheim, Klinik für Urologie und Urochirurgie

Mannheim, , Germany

Site Status NOT_YET_RECRUITING

Countries

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Germany

Central Contacts

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Sigrun Holze, Dr.

Role: CONTACT

Phone: 0049 341 9717600

Email: [email protected]

Nicole Köppe-Bauernfeind

Role: CONTACT

Phone: 0049 341 97 16266

Email: [email protected]

Facility Contacts

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Christian Thomas, Prof.

Role: primary

Jens-Uwe Stolzenburg, Prof.

Role: primary

Sigrun Holze, Dr.

Role: backup

Hoang Minh Do, PD Dr.

Role: primary

Matthias Oelke, Prof.

Role: primary

Stefan Siemer, Prof.

Role: primary

Martin Schostak, Prof.

Role: primary

Axel Haferkamp, Prof.

Role: primary

Karl-Friedrich Kowalewski, PD Dr.

Role: primary

References

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Holze S, Steiner C, Dietel A, Franz T, Thi PH, Koppe-Bauernfeind N, Bacak M, Mende M, Stolzenburg JU. Virtual Interactive 3D Modeling to Improve Outcomes in Robot-Assisted Partial Nephrectomy: Clinical Trial Protocol for the Multicenter, Randomized 3DPN Study. Eur Urol Open Sci. 2025 May 19;76:58-64. doi: 10.1016/j.euros.2025.04.004. eCollection 2025 Jun.

Reference Type DERIVED
PMID: 40492117 (View on PubMed)

Other Identifiers

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3DPN

Identifier Type: -

Identifier Source: org_study_id