MYREPTIC-N® or MY-REPT® in Stable Patients After Kidney Transplant Recipients

NCT ID: NCT06044493

Last Updated: 2024-12-16

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

PHASE4

Total Enrollment

158 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-11-15

Study Completion Date

2025-11-30

Brief Summary

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The purpose of this study is to Evaluate the Efficacy and Safety of MYREPTIC-N® or MY-REPT® in Stable Patients after Kidney Transplant Recipients

Detailed Description

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This study is a multi-center, Randomized, Open-label and phase IV clinical trial that evaluates the efficacy and safety of MYREPTIC-N® or MY-REPT® administration for 24 weeks in renal transplant patients combined Calcineurin inhibitor.

Conditions

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Kidney Transplant

Keywords

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Kidney transplant Mycophenolic acid

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Myreptic-N Tablet

Mycophenolate sodium

Group Type EXPERIMENTAL

Myreptic-N Tablet

Intervention Type DRUG

Up to 720mg BID(total 1440mg daily), PO - Check the blood concentration of Mycophenolate at each visit

Myrept Tablet/Capsule

Mycophenolate mofetil

Group Type ACTIVE_COMPARATOR

Mycophenolate mofetil Tablet/Capsule

Intervention Type DRUG

Up to 1g BID(total 2g daily), PO - Check the blood concentration of Mycophenolate at each visit

Interventions

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Myreptic-N Tablet

Up to 720mg BID(total 1440mg daily), PO - Check the blood concentration of Mycophenolate at each visit

Intervention Type DRUG

Mycophenolate mofetil Tablet/Capsule

Up to 1g BID(total 2g daily), PO - Check the blood concentration of Mycophenolate at each visit

Intervention Type DRUG

Other Intervention Names

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Myreptic-N® Myrept® Cap./Tab.

Eligibility Criteria

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Inclusion Criteria

1. Over 19 years old
2. Patients who at least 1 year after kidney transplant
3. serum creatinine ≤2.3 mg/dL
4. Patients on immunosuppressive maintenance therapy using combination of Calcineurin Inhibitor and Mycophenolate Mofetil after kidney transplantation

Exclusion Criteria

1. Patients who had received treatment Acute rejection within 4 weeks
2. Patients who had discontinued corticosteroid within 4 weeks
3. At the time of Screening

* Treatment with active liver disease or Liver function test(T-bilirubin, AST, ALT)is over 3 times than upper normal limit
* WBC\< 2,500/mm\^3, or platelet \< 75,000/mm\^3, or ANC \< 1,300/ mm\^3
4. In investigator's judgement
Minimum Eligible Age

19 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Chong Kun Dang Pharmaceutical

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Jongwon Ha, MD, PhD

Role: STUDY_CHAIR

Seoul National University Hospital

Locations

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Seoul National University Hospital

Seoul, Seoul, South Korea

Site Status RECRUITING

Countries

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South Korea

Central Contacts

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Jogwon Ha, MD, PhD

Role: CONTACT

Phone: 82-2-2072-2991

Email: [email protected]

Jung A Lee

Role: CONTACT

Phone: 82-2-2194-0403

Email: [email protected]

Facility Contacts

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Jongwon Ha, MD, PhD

Role: primary

Jung A Lee

Role: backup

Other Identifiers

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B130_01KT2203

Identifier Type: -

Identifier Source: org_study_id