Dynamics of the Upper and Lower Airway Respiratory Microbiomes Associated With Severe Infant Asthma
NCT ID: NCT06044051
Last Updated: 2023-12-28
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
100 participants
INTERVENTIONAL
2023-09-26
2026-09-26
Brief Summary
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Exploring and understanding these data is to improve patient care and discover new therapeutic targets.
The aim is to open up prospects for therapeutic studies, such as the use of azithromycin as an immunomodulator in infant asthma, the results of which are discordant.
Detailed Description
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Conditions
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Keywords
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Study Design
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NA
SINGLE_GROUP
PREVENTION
NONE
Study Groups
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All patients
All patients included will be followed for 1 year, every 3 months
Blood sample
An additionnal volume of blood will be collected at inclusion and at each follow-up visit
Expectoration
Expectoration will be collected at inclusion and at each follow-up visit
Nasopharyngeal swab
A nasopharyngeal swab will be collected at inclusion and at each follow-up visit after an induced sputum
Interventions
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Blood sample
An additionnal volume of blood will be collected at inclusion and at each follow-up visit
Expectoration
Expectoration will be collected at inclusion and at each follow-up visit
Nasopharyngeal swab
A nasopharyngeal swab will be collected at inclusion and at each follow-up visit after an induced sputum
Eligibility Criteria
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Inclusion Criteria
* Follow-up by a pneumo-pediatrician for severe asthma in infants
* Requiring etiological investigations and assessment of severity in day hospitalization, including bronchial fibroscopy (HAS 2009)
* Parent informed of the research and having signed consent
Exclusion Criteria
* Congenital heart disease with significant left to right shunt
* Chronic respiratory disease other than infant asthma (cystic fibrosis, bronchiolitis obliterans)
* Antibiotic therapy in progress or administered the seven days preceding the date of inclusion (day hospitalization)
* Refusal of bronchial fibroscopy
24 Months
ALL
No
Sponsors
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University Hospital, Rouen
OTHER
Responsible Party
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Principal Investigators
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PETAT Hortense
Role: PRINCIPAL_INVESTIGATOR
University Hospital, Rouen
Locations
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Rouen University Hospital
Rouen, , France
Countries
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Central Contacts
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Facility Contacts
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Hortense PETAT
Role: primary
References
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Petat H, Hassel C, Michel A, Charbonnier C, Plantier JC, Marguet C. Microbiosthma: a prospective study following respiratory microbiota in young children with severe preschool wheezing to better understand their respiratory future. BMC Pulm Med. 2025 Jul 16;25(1):342. doi: 10.1186/s12890-025-03812-9.
Other Identifiers
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2023/0091/OB
Identifier Type: -
Identifier Source: org_study_id