Bone and Inflammatory Outcomes - Nutrition and Exercise Trials
NCT ID: NCT06041087
Last Updated: 2023-12-18
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.
RECRUITING
NA
25 participants
INTERVENTIONAL
2023-11-01
2025-09-01
Brief Summary
Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.
Detailed Description
Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.
Design: Randomized controlled crossover trial
Participants: Healthy, university aged males and females.
Methods: During the study participants will complete 4 different acute exercise and nutritional supplement trials, in random order. The four trials are: 1) exercise+carbohydrate (CHO), 2) exercise+milk (Milk), 3) exercise+Greek yogurt (GY), and 4) exercise+water (W). The whole study will take a maximum of 16 weeks and each supplement trial will be separated by 2-4 weeks.
Outcomes: several markers of bone turnover and bone cell activity as well as markers of inflammation will be measured in the blood, before exercise and at different times post-exercise and post supplement consumption.
Conditions
See the medical conditions and disease areas that this research is targeting or investigating.
Keywords
Explore important study keywords that can help with search, categorization, and topic discovery.
Study Design
Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.
RANDOMIZED
CROSSOVER
BASIC_SCIENCE
SINGLE
Study Groups
Review each arm or cohort in the study, along with the interventions and objectives associated with them.
Exercise and Greek Yogurt (GY)
Participants will have a fasted baseline blood sample taken upon arrival to the lab. Then they will take part in a high-intensity exercise protocol, consisting of high-intensity interval cycling, resistance exercise, and plyometrics. Following exercise, participants will return to the lab for a 5min post-exercise blood sample, and then consume \~200g Greek yogurt (0% milk fat). An additional blood sample will be taken at 1h post-exercise, followed by an additional \~200g of Greek yogurt. Blood samples will also be taken at 4h and 24h post-exercise. Participants will also rate their muscle soreness and perform a jump height test at pre-exercise, 5min post-exercise, 4h and 24h post-exercise.
High-Intensity Exercise
A single bout of high-intensity exercise (cycling intervals, resistance exercise, plyometrics) per trial.
Greek yogurt
200g consumed immediately after exercise and 1h after exercise.
Exercise and Milk (Milk)
Participants will have a fasted baseline blood sample taken upon arrival to the lab. Then they will take part in a high-intensity exercise protocol, consisting of high-intensity interval cycling, resistance exercise, and plyometrics. Following exercise, participants will return to the lab for a 5min post-exercise blood sample, and then consume \~500ml plain skim milk (0% milk fat). An additional blood sample will be taken at 1h post-exercise, followed by an additional \~500ml of skim milk. Blood samples will also be taken at 4h and 24h post-exercise. Participants will also rate their muscle soreness and perform a jump height test at pre-exercise, 5min post-exercise, 4h and 24h post-exercise.
High-Intensity Exercise
A single bout of high-intensity exercise (cycling intervals, resistance exercise, plyometrics) per trial.
Skim Milk
500ml consumed immediately after exercise and 1h after exercise.
Exercise and Carbohydrate (CHO)
Participants will have a fasted baseline blood sample taken upon arrival to the lab. Then they will take part in a high-intensity exercise protocol, consisting of high-intensity interval cycling, resistance exercise, and plyometrics. Following exercise, participants will return to the lab for a 5min post-exercise blood sample, and then consume \~50g of maltodextrin mixed with water (\~500ml). An additional blood sample will be taken at 1h post-exercise, followed by an additional \~500ml of the maltodextrin drink. Blood samples will also be taken at 4h and 24h post-exercise. Participants will also rate their muscle soreness and perform a jump height test at pre-exercise, 5min post-exercise, 4h and 24h post-exercise.
High-Intensity Exercise
A single bout of high-intensity exercise (cycling intervals, resistance exercise, plyometrics) per trial.
Carbohydrate (Maltodextrin powder mixed with water)
50g consumed immediately after exercise and 1h after exercise.
Exercise and Water (W)
Participants will have a fasted baseline blood sample taken upon arrival to the lab. Then they will take part in a high-intensity exercise protocol, consisting of high-intensity interval cycling, resistance exercise, and plyometrics. Following exercise, participants will return to the lab for a 5min post-exercise blood sample, and then consume \~500ml water. An additional blood sample will be taken at 1h post-exercise, followed by an additional \~500ml water. Blood samples will also be taken at 4h and 24h post-exercise. Participants will also rate their muscle soreness and perform a jump height test at pre-exercise, 5min post-exercise, 4h and 24h post-exercise.
High-Intensity Exercise
A single bout of high-intensity exercise (cycling intervals, resistance exercise, plyometrics) per trial.
Water
500ml consumed immediately after exercise and 1h after exercise.
Interventions
Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.
High-Intensity Exercise
A single bout of high-intensity exercise (cycling intervals, resistance exercise, plyometrics) per trial.
Carbohydrate (Maltodextrin powder mixed with water)
50g consumed immediately after exercise and 1h after exercise.
Skim Milk
500ml consumed immediately after exercise and 1h after exercise.
Greek yogurt
200g consumed immediately after exercise and 1h after exercise.
Water
500ml consumed immediately after exercise and 1h after exercise.
Other Intervention Names
Discover alternative or legacy names that may be used to describe the listed interventions across different sources.
Eligibility Criteria
Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.
Inclusion Criteria
* Normal BMI (18.5-24.9) kg/m\^2
* Low to moderately physically active (0-2 times/week)
* No allergy to dairy protein or lactose intolerance
* On no medication related to a chronic condition
* On birth control or naturally cycling with a regular menstrual cycle)
Exclusion Criteria
* Any chronic condition, inflammatory, or auto-immune condition
18 Years
30 Years
ALL
Yes
Sponsors
Meet the organizations funding or collaborating on the study and learn about their roles.
York University
OTHER
Responsible Party
Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.
Andrea Josse
Assistant Professor
Principal Investigators
Learn about the lead researchers overseeing the trial and their institutional affiliations.
Andrea R Josse, PhD
Role: PRINCIPAL_INVESTIGATOR
York University
Locations
Explore where the study is taking place and check the recruitment status at each participating site.
York University
Toronto, Ontario, Canada
Countries
Review the countries where the study has at least one active or historical site.
Central Contacts
Reach out to these primary contacts for questions about participation or study logistics.
Facility Contacts
Find local site contact details for specific facilities participating in the trial.
Andrea R Josse, PhD
Role: primary
Emily C Fraschetti, MSc
Role: backup
Other Identifiers
Review additional registry numbers or institutional identifiers associated with this trial.
2019-045b
Identifier Type: -
Identifier Source: org_study_id