Active Screening of Latent Tuberculosis Infection in School Contacts of Active Tuberculosis Patients
NCT ID: NCT06033807
Last Updated: 2025-04-01
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
31440 participants
OBSERVATIONAL
2023-09-01
2025-12-31
Brief Summary
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* the proportion of MTB infection among school contacts of ATB patients
* risk factors related to tuberculosis (TB) infection
* health economic evaluation of screening strategy
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Detailed Description
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Conditions
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Study Design
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OTHER
CROSS_SECTIONAL
Study Groups
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Contacts
School contacts of ATB patients
QuantiFERON-TB Gold (QFT) test
Participants will be tested by QuantiFERON-TB Gold (QFT) test to see if they have ever infected by MTB. Those with positive results will proceed to sputum Xpert MTB/RIF, physical examination and chest CT scan, as well as sputum culture if necessary to distinguish latent TB infection (LTBI) from ATB. X-ray scan is conditional on age above 15 years with a positive QuantiFERON-TB Gold (QFT) test result.
Interventions
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QuantiFERON-TB Gold (QFT) test
Participants will be tested by QuantiFERON-TB Gold (QFT) test to see if they have ever infected by MTB. Those with positive results will proceed to sputum Xpert MTB/RIF, physical examination and chest CT scan, as well as sputum culture if necessary to distinguish latent TB infection (LTBI) from ATB. X-ray scan is conditional on age above 15 years with a positive QuantiFERON-TB Gold (QFT) test result.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Students in junior middle school, high school and university;
* Close contact of school active tuberculosis case (e.g. in the same classroom, in the same dormitory);
* Himself/herself (together with his/her guardian for age under 18 years old) willing to participate in trial and sign informed consent.
Exclusion Criteria
* Have completed a full course of treatment for ATB or LTBI
13 Years
ALL
No
Sponsors
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Guizhou Center for Disease Control and Prevention
OTHER
Huashan Hospital
OTHER
Responsible Party
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Wen-hong Zhang
Professor
Principal Investigators
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Wenhong Zhang, PhD
Role: PRINCIPAL_INVESTIGATOR
Huashan Hospital
Locations
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Xinpu New Area Center of Disease Control
Zunyi, Guiyang, China
Dafang Center for Disease Control and Prevention
Bijie, Guizhou, China
Qixingguan Center for Disease Control and Prevention
Bijie, Guizhou, China
Nayong Center for Disease Control and Prevention
Bijie, Guizhou, China
Hezhang Center for Disease Control
Bijie, Guizhou, China
Jinsha Center for Disease Control
Bijie, Guizhou, China
Qianxi Center of Disease Control
Bijie, Guizhou, China
Weining Center of Disease Control
Bijie, Guizhou, China
Zhijin Center of Disease Control
Bijie, Guizhou, China
Liping Center for Disease Control and Prevention
Linping, Guizhou, China
Liuzhi Special District Center of Disease Control
Liupanshui, Guizhou, China
Panzhou Center of Disease Control
Liupanshui, Guizhou, China
Shuicheng District Center of Disease Control
Liupanshui, Guizhou, China
Cengong Center of Disease Control
Qiandongnan Miao and Dong Autonomous Prefecture, Guizhou, China
Congjiang Ceter of Disease Control
Qiandongnan Miao and Dong Autonomous Prefecture, Guizhou, China
Danzhai Center of Disease Control
Qiandongnan Miao and Dong Autonomous Prefecture, Guizhou, China
Huangping Center of Disease Control
Qiandongnan Miao and Dong Autonomous Prefecture, Guizhou, China
Jianhe Center of Disease Control
Qiandongnan Miao and Dong Autonomous Prefecture, Guizhou, China
Jinping Center of Disease Control
Qiandongnan Miao and Dong Autonomous Prefecture, Guizhou, China
Kaili Center of Disease Control
Qiandongnan Miao and Dong Autonomous Prefecture, Guizhou, China
Leishan Center of Disease Control
Qiandongnan Miao and Dong Autonomous Prefecture, Guizhou, China
Majiang Center of Disease Control
Qiandongnan Miao and Dong Autonomous Prefecture, Guizhou, China
Rongjiang Center of Disease Control
Qiandongnan Miao and Dong Autonomous Prefecture, Guizhou, China
Sansui Center of Disease Control
Qiandongnan Miao and Dong Autonomous Prefecture, Guizhou, China
Shibing Center of Disease Control
Qiandongnan Miao and Dong Autonomous Prefecture, Guizhou, China
Taijiang Center of Disease Control
Qiandongnan Miao and Dong Autonomous Prefecture, Guizhou, China
Tianzhu Center of Disease Control
Qiandongnan Miao and Dong Autonomous Prefecture, Guizhou, China
Zhenyuan Center of Disease Control
Qiandongnan Miao and Dong Autonomous Prefecture, Guizhou, China
Qingzhen Center for Disease Control and Prevention
Qingzhen, Guizhou, China
Bozhou District Center of Disease Control
Zunyi, Guizhou, China
Chishui Center of Disease Control
Zunyi, Guizhou, China
Daozhen Center of Disease Control
Zunyi, Guizhou, China
Fenggang Center of Disease Control
Zunyi, Guizhou, China
Honghuagang District Center of Disease Control
Zunyi, Guizhou, China
Huichuan District Center of Disease Control
Zunyi, Guizhou, China
Meitan Center of Disease Control
Zunyi, Guizhou, China
Renhuai Center of Disease Control
Zunyi, Guizhou, China
Suiyang Center of Disease Control
Zunyi, Guizhou, China
Tongzi Center of Disease Control
Zunyi, Guizhou, China
Wuchuan Center of Disease Control
Zunyi, Guizhou, China
Xishui Center of Disease Control
Zunyi, Guizhou, China
Yuqing Center of Disease Control
Zunyi, Guizhou, China
Zhengan Center of Disease Control
Zunyi, Guizhou, China
Dalian Public Health Clinical Center
Dalian, Liaoning, China
Countries
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Central Contacts
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Facility Contacts
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Youqian Chen
Role: primary
Daochun Wan
Role: primary
Chenglin Wang
Role: primary
Quan Li
Role: primary
Yan An
Role: primary
Xia Dai
Role: primary
Tingting Gong
Role: primary
Liangqun Cai
Role: primary
Yan Cao
Role: primary
Zhibo Xu
Role: primary
Li Du
Role: primary
Yao Ren
Role: primary
Pinjun Deng
Role: primary
Liyan Cao
Role: primary
Lanzhen Li
Role: primary
Zhixin Mao
Role: primary
Li Deng
Role: primary
Weiqiong Zeng
Role: primary
Yunhua Liu
Role: primary
Hongzhi Luo
Role: primary
Xingqin Hou
Role: primary
Jianghong Li
Role: primary
Faxiang Ding
Role: primary
Yuxian Ma
Role: primary
Yuzhao Li
Role: primary
Wenzhi Jiang
Role: primary
Zhijun Gong
Role: primary
Xiaorong Huang
Role: primary
Yan Guo
Role: primary
Xuanbi Cheng
Role: primary
Kun Chen
Role: primary
Ruiai Dai
Role: primary
Yuting Zeng
Role: primary
Wenjun Chen
Role: primary
Jing Chen
Role: primary
Yao Gu
Role: primary
Yongming Cai
Role: primary
Guolu Li
Role: primary
Lianlian Bi
Role: primary
Lilan He
Role: primary
Jie Chen
Role: primary
Ya Zeng
Role: primary
Zheng Cao
Role: primary
Xu Cao, MD
Role: primary
Other Identifiers
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TB-Youth Screening
Identifier Type: -
Identifier Source: org_study_id
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