Ciprofol vs Propofol for Reducing Hypoxia Incidence in ERCP

Summary

Intravenous anesthesia has been widely used in endoscopic retrograde cholangiopancreatography (ERCP). In the past decade, many practices have been carried out under the propofol-based monitored anesthesia care without endotracheal intubation in patients undergoing ERCP.

Ciprofol is a newly developed intravenous anesthetic with a potency 4-5 times than that of propofol. Ciprofol seems a promising anesthetic agent for intravenous anesthesia but the evidence supported its application in ERCP is still limited.

Conditions

• Anesthesia; Adverse Effect
• Biliary Tract Diseases

Interventions

DRUG

Propofol

patients in Propofol group receive sufentanil(0.1ug/kg)+ propofol (1.5-2mg/kg) for anesthesia induction, and continuous infusion of propofol 5mg/kg/h for anesthesia maintain.

DRUG

Ciprofol

patients in Ciprofol group receive sufentanil(0.1ug/kg)+ ciprofol(0.4-0.5mg/kg) for anesthesia induction, and continuous infusion of ciprofol 0.8mg/kg/h for anesthesia maintain.

Sponsors & Collaborators

• RenJi Hospital

  lead OTHER

Principal Investigators

• Peiying Li, Doctor · Clinial Research Center, Renji Hospital

• Yu Weifeng, Doctor · Department of Anesthesiology, Renji Hospital

• Zheng Li, Master · Department of Anesthesiology, Renji Hospital

• Yanhua Zhao, Doctor · Department of Anesthesiology, Renji Hospital

• Yifeng Qu, Master · Department of Anesthesiology, Renji Hospital

• Kun Luo, Master · Department of Anesthesiology, Renji Hospital

• Guangyan Wang · Operating Room，Renji Hospital

• Teng Wang · Department of Anesthesiology, Renji Hospital

• Huichen Zhu, Master · Department of Anesthesiology, Renji Hospital

• Jing Gao, Doctor · Clinial Research Center, Renji Hospital

Study Design

Allocation

RANDOMIZED

Purpose

OTHER

Masking

DOUBLE

Model

PARALLEL

Eligibility

Min Age

18 Years

Max Age

80 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2024-06-15

Primary Completion

2024-12-31

Completion

2025-02-28

Countries

• China

Study Locations