Prediction and Evaluation of Anlotinib Treatment Response Using Contrast Enhanced Ultrasound PPGL Patients

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

UNKNOWN

Total Enrollment

20 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-03-01

Study Completion Date

2025-03-01

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Anlotinib is a multi-target receptor tyrosine kinase inhibitor (TKI) targeting tumor angiogenesis and growth. The purpose of this study is to evaluate the efficiency of contrast enhanced ultrasound in assessing effectiveness of anlotinib in patients with locally advanced, metastatic, or unresectable pheochromocytoma or paraganglioma(PPGL).

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

A Study on the Safety and Effectiveness of Anlotinib for Neoadjuvant Treatment of PPGL

NCT05883085

Pheochromocytoma Paraganglioma

UNKNOWN PHASE2

A Prospective Phase II Efficacy and Safety Study of Anlotinib in Metastatic or Locally Advanced Pheochromocytoma/ Paraganglioma : Open-label Single-arm, Exploratory Trial

NCT05133349

Advanced or Metastatic Paraganglioma/ Pheochromocytoma

UNKNOWN PHASE2

Anlotinib Combined With Benmelstobart for Advanced Pheochromocytoma

NCT06429397

Pheochromocytoma

NOT_YET_RECRUITING PHASE2

The Efficacy and Safety of Anlotinib in Patients With Metastatic Pheochromocytoma or Paraganglioma

NCT04860700

Malignant Adrenal Gland Pheochromocytoma Malignant Paraganglioma Pheochromocytoma, Metastatic +2 more

COMPLETED PHASE2

Anlotinib Combined With Penpulimab as Front-line Treatment in Advanced Non-small Cell Lung Cancer

NCT06341530

Non-small Cell Lung Cancer

RECRUITING PHASE2

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Contrast-enhanced ultrasound (CEUS) is a non-invasive and efficient imaging technique which can observe the blood flow at the tissue perfusion level with microbubble contrast agents and obtain information about tumor perfusion. There have been several studies demonstrating the utility of CEUS for early prediction of response to neoadjuvant chemotherapy in breast cancer, pancrearic cancer as well as lymphoma. However, few studies have reported the use of CEUS for the evaluation of therapeutic response in PPGL. What quantitative parameters of CEUS can early reflect the neovascular changes after treatment with anlotinib in patients with locally advanced, metastatic, or unresectable PPGL? The aim of our study is to evaluate the parameters for CEUS imaging and the therapeutic response of PPGL before and after anlotinib therapy and to determine the most useful CEUS response parameters.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Pheochromocytoma, Metastatic Ultrasonography Paraganglioma, Malignant Pheochromocytoma Malignant

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Pheochromocytoma or Paraganglioma Patients with Anlotinib Treatment

to evaluate the efficiency of contrast enhanced ultrasound in assessing effectiveness of anlotinib in patients with locally advanced, metastatic, or unresectable pheochromocytoma or paraganglioma(PPGL).

Contrast-enhanced ultrasound(CEUS)

Intervention Type DIAGNOSTIC_TEST

CEUS is a quantitative kinetic imaging modality that can assess intravascular blood flow in PPGL tumors.

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Contrast-enhanced ultrasound(CEUS)

CEUS is a quantitative kinetic imaging modality that can assess intravascular blood flow in PPGL tumors.

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* 18 years of age or older.
* Provide written informed consent.
* Willing to return to enrolling institution for follow-up.
* Eastern Cooperative Oncology Group (ECOG) performance status 0, 1, or 2.
* Life expectancy \> 3 months.
* Patients diagnosis with pheochromocytoma or paraganglioma will received anlotinib treatment.
* Laboratory requirements:

* Absolute granulocyte count (AGC) greater than 1.5 x 109/L;
* Platelet count greater than 80 x 109/L;
* Hemoglobin greater than 90g/L;
* Serum bilirubin less than 1.5 x upper limit of normal (ULN);
* Serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) less than 2.5 x ULN;
* Serum creatinine less than 1.5 x ULN or creatinine clearance (CCr)≥60ml/min;
* Doppler ultrasound assessment: left ventricular ejection fraction (LVEF) ≥ lower limit of normal value (50%).

Exclusion Criteria

* Patients who are allergic to ultrasound contrast agents.
* Any of the following:Pregnant women,Nursing women,Men or women of childbearing potential who are unwilling to employ adequate contraception.
* Patients who have previously used other anti-vascular targeted drugs, such as sunitinib, bevacizumab, endurance, etc.
* Chemotherapy/systemic therapy, radiotherapy, immunotherapy or surgery within 4 weeks prior to kinase inhibitor therapy.
* Patients with another primary malignancy within 5 years prior to starting study drug.

Those who have multiple factors that affect oral medications (such as inability to swallow, chronic diarrhea, intestinal obstruction, etc.).

* Patients with known untreated brain metastases are excluded. Patients having a history of brain metastasis that have been previously irradiated or resected greater than 2 months prior to enrollment and are clinically and radiographically stable will be considered for enrollment. Patients with brain metastases with symptoms or symptom control for less than 2 months.
* Active or uncontrolled intercurrent illness including, but not limited to

* Patients with unsatisfactory blood pressure control (systolic blood pressure ≥150 mmHg, diastolic blood pressure ≥100 mmHg);
* Patients with uncontrolled myocardial ischemia or myocardial infarction, arrhythmia (including QTC≥480ms), and uncontrolled congestive heart failure，grade ≥2（New York Heart Association )
* ongoing or active infection;
* Liver cirrhosis, decompensated liver disease, active hepatitis or chronic hepatitis require antiviral treatment;
* Renal failure requires hemodialysis or peritoneal dialysis;
* Have a history of immunodeficiency, including HIV or other acquired or congenital immunodeficiency diseases, or a history of organ transplantation;
* Diabetes is poorly controlled (fasting blood glucose (FBG)\> 10mmol/L);
* Urine routines suggest that urine protein is ≥++, and the 24-hour urine protein content is confirmed to be greater than 1.0 g;
* Patients who have seizures and need treatment;
* Any of the following conditions =\< 6 months prior to registration: Cerebrovascular accident (CVA) or transient ischemic attack (TIA); Serious or unstable cardiac arrhythmia; Pulmonary embolism, untreated deep venous thrombosis (DVT).

Received major surgical treatment, open biopsy or obvious traumatic injury within 28 days before enrollment.

* Those who have a history of psychotropic drug abuse and cannot be quit or have mental disorders.
* Imaging shows that the tumor has invaded important blood vessels or the investigator judges that the tumor is very likely to invade important blood vessels and cause fatal bleeding during the follow-up study.
* Regardless of the severity, patients with any signs of bleeding or medical history; within 4 weeks before enrollment, patients with any bleeding or bleeding event ≥ CTCAE grade 3, unhealed wounds, ulcers or fractures.
* Patients are using drugs that interact with Anlotinib.

Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No