Risk Factors for Severe Disease in Hospitalized Patients With COVID-19 and the Effect of Azvudine Treatment: a Retrospective Cohort Study

NCT ID: NCT06006611

Last Updated: 2023-09-21

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

4201 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-08-05

Study Completion Date

2023-10-30

Brief Summary

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The purpose of this study is to explore the factors that can affect the development of severe cases in hospitalized patients with COVID-19, including basic diseases, laboratory parameters, and clinical manifestations; In addition,to explore whether Azvudine can reduce the mortality of hospitalized patients with COVID-19.

Detailed Description

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4201 COVID-19 patients discharged from our hospital were enrolled. Binary logistic regression analysis and ROC curve were used to investigate the role of comorbidities, laboratory parameters and clinical manifestation on progression of COVID-19 patients. We used propensity-score models conditional on baseline characteristics and Univariate Cox regression model to examine whether Azvudine can reduce the mortality of COVID-19 patients.

Conditions

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COVID-19

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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Azvudine group

Azvudine group included COVID-19 patients treated with azvudine antiviral therapy;

Azvudine

Intervention Type DRUG

Received antiviral treatment with azvudine

No antiviral group

No antiviral group included COVID-19 patients treated with no antiviral therapy;

No interventions assigned to this group

Monotamivir

Monotamivir group included COVID-19 patients treated with monotamivir antiviral therapy

No interventions assigned to this group

Interventions

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Azvudine

Received antiviral treatment with azvudine

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

The COVID-19 positive patients

Exclusion Criteria

1. patients treated with both azvudine and monotamivir;
2. patients receiving other antiviral drugs such as nematavir/ritonavir;
3. age \< 18 years old
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Fifth Affiliated Hospital, Sun Yat-Sen University

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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The Fifth Affiliated Hospital of Sun Yat-sen University

Zhuhai, Guangdong, China

Site Status

Countries

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China

Other Identifiers

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ZDWY.BAS.001

Identifier Type: -

Identifier Source: org_study_id

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