Needle Free Assessment of Myocardial Oxygenation in Healthy Subjects
NCT ID: NCT06000540
Last Updated: 2025-08-22
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.
NOT_YET_RECRUITING
NA
80 participants
INTERVENTIONAL
2026-01-10
2027-06-15
Brief Summary
Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.
Related Clinical Trials
Explore similar clinical trials based on study characteristics and research focus.
Utilizing Carbon Dioxide for Assessing Coronary Blood Flow in Subjects With Coronary Artery Disease
NCT06253884
Correlation of Hemodynamics Via Pulmonary Artery Catherization and the Cardiospire
NCT05003011
Noninvasive Determination of Cerebral Tissue Oxygenation in Pulmonary Hypertension
NCT01463514
N600X Low Saturation Accuracy Validation
NCT05532670
Comparaison of 2 SpO2 Level Measured by Pulse Oxymetry in Complications of Acute Coronary Syndrome.
NCT03122210
Detailed Description
Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.
Conditions
See the medical conditions and disease areas that this research is targeting or investigating.
Study Design
Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.
NON_RANDOMIZED
PARALLEL
OTHER
NONE
Study Groups
Review each arm or cohort in the study, along with the interventions and objectives associated with them.
Hypercapnia Group A
Healthy subjects without a history of coronary artery disease will undergo computer-controlled gas challenges.
RespirAct
RespirAct device-based computer-controlled gas delivery at different concentrations as per protocol
Hypercapnia Group B
Healthy subjects without a history of coronary artery disease will undergo computer-controlled gas challenges.
RespirAct
RespirAct device-based computer-controlled gas delivery at different concentrations as per protocol
Hypercapnia Group C
Healthy subjects without a history of coronary artery disease will undergo computer-controlled gas challenges.
RespirAct
RespirAct device-based computer-controlled gas delivery at different concentrations as per protocol
Hypoxia Group
Healthy subjects without a history of coronary artery disease will undergo computer-controlled gas challenges.
RespirAct
RespirAct device-based computer-controlled gas delivery at different concentrations as per protocol
Interventions
Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.
RespirAct
RespirAct device-based computer-controlled gas delivery at different concentrations as per protocol
Eligibility Criteria
Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.
Inclusion Criteria
2. No known cardiac disease
Exclusion Criteria
2. Inability to voluntarily increase their breathing rate if prompted to do so
3. Persons with the inability to lie supine for 30-40 minutes
4. Persons who are pregnant, nursing, or implanted with intrauterine devices (IUD's)
5. Persons with significant neurological, pulmonary, renal or hepatic disease
6. Persons who have an abnormal cardiac rhythm or resting heart rate \>100/min
7. Inability or unwillingness to provide informed consent
45 Years
ALL
Yes
Sponsors
Meet the organizations funding or collaborating on the study and learn about their roles.
Indiana University
OTHER
Responsible Party
Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.
Rohan Dharmakumar
Executive Director, Krannert Cardiovascular Research Center
Locations
Explore where the study is taking place and check the recruitment status at each participating site.
IU Health Methodist Hospital
Indianapolis, Indiana, United States
Countries
Review the countries where the study has at least one active or historical site.
Central Contacts
Reach out to these primary contacts for questions about participation or study logistics.
Facility Contacts
Find local site contact details for specific facilities participating in the trial.
References
Explore related publications, articles, or registry entries linked to this study.
Yang HJ, Dey D, Sykes J, Butler J, Biernaski H, Kovacs M, Bi X, Sharif B, Cokic I, Tang R, Slomka P, Prato FS, Dharmakumar R. Heart Rate-Independent 3D Myocardial Blood Oxygen Level-Dependent MRI at 3.0 T with Simultaneous 13N-Ammonia PET Validation. Radiology. 2020 Apr;295(1):82-93. doi: 10.1148/radiol.2020191456. Epub 2020 Feb 25.
Poublanc J, Sobczyk O, Shafi R, Sayin ES, Schulman J, Duffin J, Uludag K, Wood JC, Vu C, Dharmakumar R, Fisher JA, Mikulis DJ. Perfusion MRI using endogenous deoxyhemoglobin as a contrast agent: Preliminary data. Magn Reson Med. 2021 Dec;86(6):3012-3021. doi: 10.1002/mrm.28974. Epub 2021 Oct 22.
Spano VR, Mandell DM, Poublanc J, Sam K, Battisti-Charbonney A, Pucci O, Han JS, Crawley AP, Fisher JA, Mikulis DJ. CO2 blood oxygen level-dependent MR mapping of cerebrovascular reserve in a clinical population: safety, tolerability, and technical feasibility. Radiology. 2013 Feb;266(2):592-8. doi: 10.1148/radiol.12112795. Epub 2012 Nov 30.
Other Identifiers
Review additional registry numbers or institutional identifiers associated with this trial.
15803
Identifier Type: -
Identifier Source: org_study_id
More Related Trials
Additional clinical trials that may be relevant based on similarity analysis.