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The Potential Association of Long Non-coding RNA (NEAT1 and MALAT1) in the Process of Epithelial-mesenchymal Transition in Periodontitis

NCT ID: NCT05995067

Last Updated: 2023-12-12

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Total Enrollment

48 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-02-14

Study Completion Date

2024-01-30

Brief Summary

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Periodontitis is a polymicrobial, inflammatory condition affecting tooth-supporting tissues. It is characterized by a progressive loss of epithelial attachment and resorption of alveolar bone, which can lead to tooth loss. Epithelial-mesenchymal transition (EMT) has been proposed as a reversible process that shifts the cell phenotype from epithelial to mesenchymal-like and may be involved in the process of periodontal inflammation either completely or partially. Long non-coding RNAs (lncRNAs) are a large class of regulatory transcripts longer than 200 nucleotides lacking evident protein-coding potential. Studies have shown that lncRNA dysregulation plays key roles in human diseases, including cancer, by modulating the epithelial-mesenchymal transition (EMT). The involvement of lncRNAs markers in the pathogenesis of periodontal disease induced EMT has not been studied thoroughly and have created a gap in the knowledge.

Detailed Description

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Conditions

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Periodontal Disease, AVDC Stage 3and 4 Epithelial Mesenchymal Transition Long Noncoding RNA

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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control group

-healthy groups/without the condition

No interventions assigned to this group

study group

-diseased group-/with the condition (periodontitis)

periodontitis challenge

Intervention Type OTHER

control will be compared to diseased group suffering from periodontal disease.

Interventions

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periodontitis challenge

control will be compared to diseased group suffering from periodontal disease.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Patients with no history of systemic disease e.g., diabetes.
* Both males and females will be included in the study.
* Control group: patients fit the case definition of gingival health2, and confirmed by Histopathological inflammatory cell infiltration analysis.
* Periodontitis group: patients fit the case definition of periodontal disease referred for periodontal flap surgery (modified Widman's flap).
* Patients radiographically confirmed with infrabony pocket eligible for periodontal flap surgery.

Exclusion Criteria

* Patients not willing to participate or consent.
* Patient taking medications that affect or modify immunity (e.g., corticosteroid), for the last 3 months.
* Patient taking NSAIDs for the last 3 months.
* Active smoker.
Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Ali A Abdulkareem

OTHER

Sponsor Role lead

Responsible Party

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Ali A Abdulkareem

assistant professor- department of periodontics-college of dentistry- Baghdad university

Responsibility Role SPONSOR_INVESTIGATOR

Locations

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saif mohammed T AL Mufti

Baghdad, , Iraq

Site Status

Countries

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Iraq

Other Identifiers

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lncRNA in periodontal disease

Identifier Type: -

Identifier Source: org_study_id