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Myocardial Infarction Triggers and Onset in Jordan Study 2

NCT ID: NCT05992012

Last Updated: 2023-12-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Total Enrollment

1000 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-10-01

Study Completion Date

2023-12-25

Brief Summary

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A previous study (MINTOR 1) found that 43% of ST elevation myocardial infarction (STEMI) patients in Jordan had a triggering events. Fifteen years later, with changing demographics and in the post covid-19 time, we believe that triggered acute myocardial infarction might have changed in incidence and nature of the triggering events.

Detailed Description

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The onset of acute ST elevation myocardial infarction (STEMI) is a complex interplay of internal circadian factors and external physical and emotional triggers. These interactions may lead to rupture of an often nonocclusive vulnerable atherosclerotic coronary plaque with subsequent formation of an occlusive thrombus. The onset of MI has a distinct pattern, with peak incidence within the first few hours after awakening, on certain days of the week, and in the winter months. Physical and emotional stresses are important triggers of acute cardiovascular events including MI. Triggering events, internal changes, and external factors vary among different geographical, environmental, and ethnic regions. Life-style changes, pharmacotherapy, and psychologic interventions may potentially modify the response to, and protect against the effects of triggering events.

MINTOR 1 showed that 43% of 900+ Jordanians with STEMI were exposed to a physical or emotional triggers before the onset of the heart attack. It was also found that Friday was the day of the week that witnessed more MIs that other days of the week and that 55% of MIs occurred in the early morning hours.

It is largely unknown if the frequency and types of triggers, onset time of MI, day with peak of MI incidence have changed over time in Jordan with changing population demographics, especially in the post Covid-19 times. These patients will be followed up for 3 years for occurring of incident vascular events.

Conditions

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Triggers of Acute Myocardial Infarction Time of Onset of Acute Myocardial Infarction Long-term Prognosis After Acute Myocardial Infarction

Keywords

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Acute myocardial infarction Acute ST-segment elevation myocardial infarction Triggers of acute myocardial infarction Middle East Prognosis

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Age 18 years and above.
* Documented acute ST elevation myocardial infarction.
* Willing to sign an informed consent.
* Available contact numbers for a 3-year follow up

Exclusion Criteria

* Unwilling to sign an informed consent.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Jordan Collaborating Cardiology Group

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Daria Jaara, MD

Role: STUDY_DIRECTOR

Istishari Hospital

Locations

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Istishari Hospital

Amman, , Jordan

Site Status

Countries

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Jordan

Other Identifiers

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CVAG.MINTOR2.7AUG23

Identifier Type: -

Identifier Source: org_study_id